The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study
Abstract
Cucurbit[n]urils (CB[n]) are potential stabilizing, solubilizing, activating, and delivering agents for drugs. The toxicity of the macrocyclic host molecules cucurbit[7]uril (CB[7]), the most water-soluble homologue, as well as cucurbit[8]uril (CB[8]) has been evaluated. In vitro studies on cell cultures revealed an IC(50) value of 0.53 +/- 0.02 mM for CB[7], corresponding to around 620 mg of CB[7] per kg of cell material. Live-cell imaging studies performed on cells treated with subtoxic amounts of CB[7] showed no detrimental effects on the cellular integrity as assessed by mitochondrial activity. For CB[8], no significant cytotoxicity was observed within its solubility range. The bioadaptability of the compounds was further examined through in vivo studies on mice, where intravenous administration of CB[7] showed a maximum tolerated dosage of 250 mg kg(-1), while oral administration of a CB[7]/CB[8] mixture showed a tolerance of up to 600 mg kg(-1). The combined results indicate a sufficiently low toxicity to encourage further exploration of CB[n] as additives for medicinal and pharmaceutical use.
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Fluorescent Dyes and Their Supramolecular Host/Guest Complexes with Macrocycles in Aqueous Solution
Dsouza, R. N., Pischel, U., & Nau, W. M. (2011) · Chemical Reviews · doi:10.1021/cr200213s · Cited by 1,117
Self-citationCucurbituril chemistry: a tale of supramolecular success
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Metadata
- Authors
- Uzunova, V. D., Cullinane, C., Brix, K., Nau, W. M., & Day, A. I.
- Venue
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 8
- Issue
- 9
- Pages
- 2037
- ISSN
- 1477-0520 (ISSN-L)
- 1477-0539
- OpenAlex
- W1982810365
- Cited by
- 383
- References
- 30
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Uzunova, V. D., Cullinane, C., Brix, K., Nau, W. M., & Day, A. I. (2010). Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study. Organic & Biomolecular Chemistry. https://doi.org/10.1039/b925555a
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