PLGA micro/nanosphere synthesis by droplet microfluidic solvent evaporation and extraction approaches
Abstract
In this paper, we present two approaches for the synthesis of poly(lactide-co-glycolide) (PLGA) micro/nanospheres using non-toxic organic solvents in droplet-based microfluidic platforms. Solvent evaporation and solvent extraction methods were employed to enable the controlled generation of monodisperse PLGA particles that range from 70 nanometres to 30 microns in diameter. Determination of particle size was carried out with dynamic light scattering (DLS) and image analysis to show less than 2% variation in particle size. Sizes of the PLGA microspheres were controlled by the PLGA concentration in solvent and by the relative flow rates of oil and aqueous phases in the system. A penetration imaging assay was performed to determine the depth of diffusion of a model drug molecule fluorescein, out of the PLGA nanoparticles into corneal tissue. With the ability to prepare high quality, monodisperse, biodegradable particles, our methods have great potential to benefit drug delivery applications.
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Several new methods for manufacturing PLGA or PLA particles have been reported, including ultrasonic atomization, electrospray, microfluidic, pore-closing/thermoreversible-gel, and microfabrication.
“Recently, several new methods to manufacture PLGA or PLA particles have been reported, such as the ultrasonic atomization method [14,15], the electrospray method [16], the microfluidic method [17,18], the pore-closing and thermoreversible-gel method [19,20], and the microfabrication method [21].”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [17]
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References 35 · Cited by 171
- Authors
- Hung, L.-H., Teh, S.-Y., Jester, J., & Lee, A. P.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Lee, Abraham P.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 10
- Issue
- 14
- Pages
- 1820
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2132347923
- Cited by
- 171
- References
- 35
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 5 · 2019: 17 · 2018: 8 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 12 · 2013: 11 · 2012: 10
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Innovative Microfluidic and Catalytic Techniques Innovation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- PLGA, poly(lactic-co-glycolic acid), droplet microfluidics, solvent evaporation, solvent extraction, monodisperse particles, particle size control, corneal tissue, biodegradable nanoparticles, drug delivery
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Gases, Microspheres, Polyglycolic Acid, Solvents, Lactic Acid, Nanotechnology, Microfluidic Analytical Techniques, Solid Phase Extraction, Nanospheres
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