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5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications

Rosatella, Andreia A., Simeonov, Svilen P., Frade, Raquel F. M., Afonso, Carlos A. M.·2011·Green Chemistry

Abstract

The biorefinery is an important approach for the current needs of energy and chemical building blocks for a diverse range of applications, that gradually may replace current dependence on fossil-fuel resources. Among other primary renewable building blocks, 5-hydroxymethylfurfural (HMF) is considered an important intermediate due to its rich chemistry and potential availability from carbohydrates such as fructose, glucose, sucrose, cellulose and inulin. In recent years, considerable efforts have been made on the transformation of carbohydrates into HMF. In this critical review we provide an overview of the effects of HMF on microorganisms and humans, HMF production and functional group transformations of HMF to relevant target molecules by taking advantage of the primary hydroxyl, aldehyde and furan functionalities.

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Metadata

Authors
Rosatella, A. A., Simeonov, S. P., Frade, R. F. M., & Afonso, C. A. M.
Venue
Green Chemistry
Published
2011
Volume
13
Issue
4
Pages
754
ISSN
  • 1463-9262 (ISSN-L)
  • 1463-9270
OpenAlex
W2135872679
Cited by
1,652
References
6
FWCI
58.71
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: 5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications. https://app.cochat.ai/papers/10.1039/c0gc00401d
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Rosatella, A. A., Simeonov, S. P., Frade, R. F. M., & Afonso, C. A. M. (2011). 5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications. Green Chemistry. https://doi.org/10.1039/c0gc00401d

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.