The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Two rings in them all: The labdane-related diterpenoids
Open accessAbstract
Covering: up to the end of March 2010 Unlike the majority of terpenoids, a significant fraction of the polycyclic diterpenoids (∼7000 already known) are now understood to originate from dual, rather than single, biosynthetic cyclization and/or rearrangement reactions, which proceed via a bicyclic diphosphate intermediate. The trivial name for the hydrocarbon skeleton of the most commonly found version of this biosynthetic intermediate forms the basis for a unifying “labdane-related” designation for this large super-family of natural products. Notably, many of these are found in plants, where the requisite biosynthetic machinery for gibberellin phytohormones, particularly the relevant diterpene cyclases, provides a biosynthetic reservoir that appears to have been repeatedly drawn upon to evolve new labdane-related diterpenoids. The potent biological activity of the “ancestral” gibberellins, which has led to the independent evolution of distinct gibberellin biosynthetic pathways in plants, fungi, and bacteria, is further discussed as an archetypical example of the selective pressure driving evolution of the large super-family of labdane-related diterpenoid natural products, with the observed diversification suggesting that their underlying hydrocarbon skeletal structures might serve as privileged scaffolds from which biological activity is readily derived.
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Cites
Gibberellin Metabolism and its Regulation
Yamaguchi, S. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092804 · Cited by 2,194
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The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis.
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Cited by
Traversing the fungal terpenome
Quin, M. B., Flynn, C. M., & Schmidt-Dannert, C. (2014) · Nat. Prod. Rep. · doi:10.1039/c4np00075g · Cited by 362
Terpenoid synthase structures: a so far incomplete view of complex catalysis
Gao, Y., Honzatko, R. B., & Peters, R. J. (2012) · Natural Product Reports · doi:10.1039/c2np20059g · Cited by 362
Self-citationBirtić, S., Dussort, P., Pierre, F.-X., Bily, A. C., & Roller, M. (2015) · Phytochemistry · doi:10.1016/j.phytochem.2014.12.026 · Cited by 334
Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins
Schmelz, E. A., Huffaker, A., Sims, J. W., Christensen, S. A., Lu, X., Okada, K., & Peters, R. J. (2014) · The Plant Journal · doi:10.1111/tpj.12436 · Cited by 317
Self-citationClerodane diterpenes: sources, structures, and biological activities
Li, R., Morris-Natschke, S. L., & Lee, K.-H. (2016) · Natural Product Reports · doi:10.1039/c5np00137d · Cited by 256
Metadata
- Authors
- Peters, R. J.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 27
- Issue
- 11
- Pages
- 1521
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W1973991050
- Cited by
- 433
- References
- 42
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- green
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