Natural products as a source of Alzheimer's drug leads
Open accessAbstract
This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than 180 compounds and summarizes 400 references.
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Secondary metabolites such as alkaloids, terpenoids, coumarins, and flavonoids have been reported to have potent AChE inhibitory activity.
“The secondary metabolites of the various classes such as alkaloids, terpenoids, coumarins, flavonoids, etc. have been reported to have potent AChEinhibitory activity [71,72,73,74].”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [72]
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References 390 · Cited by 404
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- Authors
- Williams, P., Sorribas, A., & Howes, M.-J. R.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Royal Botanic Gardens, Kew (GB)
- Corresponding author
- Williams, Philip
- Venue
- Nat. Prod. Rep.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 28
- Issue
- 1
- Pages
- 48-77
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- PMC
- PMC4917364
- OpenAlex
- W2066051584
- Cited by
- 404
- References
- 390
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 14 · 2023: 18 · 2022: 28 · 2021: 35 · 2020: 33 · 2019: 34 · 2018: 19 · 2017: 40 · 2016: 22 · 2015: 26 · 2014: 26 · 2013: 38 · 2012: 25
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Natural Product Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (R21AGO32405)
- National Institute on Aging (R21AG032405)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, natural products, drug leads, Alzheimer's disease therapeutics, mechanism of action, amyloid hypothesis, tau hypothesis, neurodegeneration
- MeSH terms
- Alzheimer Disease, Biological Products, Humans, Molecular Structure
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