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Conjugation of RAFT-generated polymers to proteins by two consecutive thiol–ene reactions
Abstract
Well-defined temperature-responsive polymers were covalently conjugated to model proteins by two consecutive Michael addition thiol–ene reactions. Poly(N-isopropylacrylamide) (PNIPAM) prepared by reversible addition–fragmentation chain transfer (RAFT) polymerization was aminolyzed to yield thiol-terminated chains that were subsequently reacted with excess 1,8-bis-maleimidodiethyleneglycol. The resulting maleimide-terminated polymer was reacted with bovine serum albumin and ovalbumin to yield polymer–protein conjugates by a “grafting-to” approach. The thermoresponsive nature of PNIPAM was conferred to the conjugate, as demonstrated by dynamic light scattering analysis that indicated the formation of intermolecular aggregates at elevated temperatures.
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Thiol-ene “click” reactions and recent applications in polymer and materials synthesis
Lowe, A. B. (2010) · Polym. Chem. · doi:10.1039/b9py00216b · Cited by 1,563
Cited by
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Boyd, D. A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201604615 · Cited by 512
50th Anniversary Perspective: Polymer Functionalization
Blasco, E., Sims, M. B., Goldmann, A. S., Sumerlin, B. S., & Barner-Kowollik, C. (2017) · Macromolecules · doi:10.1021/acs.macromol.7b00465 · Cited by 437
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Metadata
- Authors
- Li, M., De, P., Li, H., & Sumerlin, B. S.
- Venue
- Polymer Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 1
- Issue
- 6
- Pages
- 854
- ISSN
- 1759-9954 (ISSN-L)
- 1759-9962
- OpenAlex
- W2118511542
- Cited by
- 158
- References
- 1
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- closed
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