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Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate
Abstract
In contrast to the Pt(IV) derivatives of cisplatin, Pt(IV) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.
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Citations
Cited by
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Synthetic Methods for the Preparation of Platinum Anticancer Complexes
Wilson, J. J., & Lippard, S. J. (2014) · Chemical Reviews · doi:10.1021/cr4004314 · Cited by 630
What do we know about the reduction of Pt(IV) pro-drugs?
Wexselblatt, E., & Gibson, D. (2012) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2012.06.013 · Cited by 370
Self-citationPlatinum(iv) anticancer prodrugs – hypotheses and facts
Gibson, D. (2016) · Dalton Transactions · doi:10.1039/c6dt01414c · Cited by 286
Self-citationEncapsulation of Pt(iv) prodrugs within a Pt(ii) cage for drug delivery
Zheng, Y.-R., Suntharalingam, K., Johnstone, T. C., & Lippard, S. J. (2015) · Chemical Science · doi:10.1039/c4sc01892c · Cited by 265
Metadata
- Authors
- Zhang, J. Z., Wexselblatt, E., Hambley, T. W., & Gibson, D.
- Venue
- Chem. Commun.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 48
- Issue
- 6
- Pages
- 847-849
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2028871771
- Cited by
- 190
- References
- 0
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, J. Z., Wexselblatt, E., Hambley, T. W., & Gibson, D. (2012). Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate. Chem. Commun. https://doi.org/10.1039/c1cc16647f
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