Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species
Abstract
Oxidative and nitrosative stress induced by ROS/RNS play crucial roles in a wide range of physiological processes and are also implicated in various diseases, including cancer and neurodegenerative disorders. Sensitive and selective methods for the detection of ROS/RNS based on fluorescent and luminescent probes are of great use in monitoring the in vivo production of these species and elucidating their biological functions. This critical review highlights recent advances that have been made in the development of fluorescent and luminescent probes employed to monitor various ROS/RNS (132 references).
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Some chemiluminescent probes show improved sensitivity but still have problems with interference.
“Some of the chemiluminescent probes show improved sensitivity [156] but there are still problems with interference [157].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [157]
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References 132 · Cited by 980
- Authors
- Chen, X., Tian, X., Shin, I., & Yoon, J.
- Affiliations
- Nanjing Tech University (CN)
- Yonsei University (KR)
- Ewha Womans University (KR)
- Corresponding author
- Shin, Injae
- Yoon, Juyoung
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 40
- Issue
- 9
- Pages
- 4783
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2121280491
- Cited by
- 980
- References
- 132
- Citations by year
- 2026: 36 · 2025: 25 · 2024: 32 · 2023: 52 · 2022: 60 · 2021: 55 · 2020: 85 · 2019: 83 · 2018: 91 · 2017: 89 · 2016: 81 · 2015: 89 · 2014: 81 · 2013: 63 · 2012: 46
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- reactive oxygen species, reactive nitrogen species, fluorescent probes, luminescent probes, oxidative stress, nitrosative stress, in vivo detection, cancer, neurodegenerative diseases
- MeSH terms
- Fluorescent Dyes, Molecular Probes, Reactive Oxygen Species, Molecular Diagnostic Techniques, Reactive Nitrogen Species, Luminescence
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