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Cited by 171

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Cinchona alkaloid-based phosphoramide catalyzed highly enantioselective Michael addition of unprotected 3-substituted oxindoles to nitroolefins

Ding, Miao, Zhou, Feng, Liu, Yun-Lin, Wang, Cui-Hong, Zhao, Xiao-Li, Zhou, Jian·2011·Chemical Science

Abstract

A newly developed cinchonidine-derived phosphoramide 6b, simple and easily available, was identified as a powerful catalyst for the highly enantioselective Michael addition of both unprotected 3-aryl and 3-alkyloxindoles to β-substituted nitroalkenes to furnish the C3 quaternary stereogenic carbon center with an adjacent tertiary stereocenter in up to 21 : 1 diastereoselectivity and up to 99% enantioselectivity.

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Crossref · 10.1039/c1sc00390a

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Metadata

Authors
Ding, M., Zhou, F., Liu, Y.-L., Wang, C.-H., Zhao, X.-L., & Zhou, J.
Venue
Chemical Science
Published
2011
Volume
2
Issue
10
Pages
2035
ISSN
  • 2041-6520 (ISSN-L)
  • 2041-6539
OpenAlex
W2074683026
Cited by
171
References
1
FWCI
11.82
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cinchona alkaloid-based phosphoramide catalyzed highly enantioselective Michael addition of unprotected 3-substituted oxindoles to nitroolefins. https://app.cochat.ai/papers/10.1039/c1sc00390a
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Ding, M., Zhou, F., Liu, Y.-L., Wang, C.-H., Zhao, X.-L., & Zhou, J. (2011). Cinchona alkaloid-based phosphoramide catalyzed highly enantioselective Michael addition of unprotected 3-substituted oxindoles to nitroolefins. Chemical Science. https://doi.org/10.1039/c1sc00390a

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.