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Fluorescent dye-doped silica nanoparticles: new tools for bioapplications
Abstract
The need to decipher various biological events has led to the elucidation of the molecular mechanisms underlying a number of disease processes. Consequently, the detection and simultaneous monitoring of chemical interactions between biological targets has become indispensable in medical diagnosis, targeted therapeutics, and molecular biology. Multiplexed applications employing nanomaterials, which represent the integration of nanotechnology and biology, have changed the bioanalytical outlook and provided various promising tools. Among these nanomaterials, fluorescent dye-doped silica nanoparticles have demonstrated excellent potential for use in advanced bioanalysis to facilitate deeper understanding of biology and medicine at the molecular level. In particular, silica nanoparticles have been applied to diagnostics and therapeutic applications in cancer and gene/drug delivery. This feature article summarizes recent developments in the synthesis, biocompatibility, and bioapplications of fluorescent dye-doped silica nanoparticles.
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Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214
Cited by
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Steinegger, A., Wolfbeis, O. S., & Borisov, S. M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00451 · Cited by 622
Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems
Wen, J., Yang, K., Liu, F., Li, H., Xu, Y., & Sun, S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00219j · Cited by 477
Recent development of biotin conjugation in biological imaging, sensing, and target delivery
Ren, W. X., Han, J., Uhm, S., Jang, Y. J., Kang, C., Kim, J.-H., & Kim, J. S. (2015) · Chemical Communications · doi:10.1039/c5cc03075g · Cited by 393
Design and development of fluorescent nanostructures for bioimaging
Chen, M., & Yin, M. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.11.001 · Cited by 289
Metadata
- Authors
- Bae, S. W., Tan, W., & Hong, J.-I.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 48
- Issue
- 17
- Pages
- 2270
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2015792401
- Cited by
- 222
- References
- 1
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
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