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Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes
Abstract
The rich photophysical properties of luminescent inorganic and organometallic transition metal complexes, such as their intense, long-lived, and environment-sensitive emission, render them excellent candidates for biological and cellular studies. In this Perspective, we review examples of biological probes derived from luminescent transition metal complexes with a d(6), d(8), or d(10) metal center. The design of luminescent covalent labels and noncovalent probes for protein molecules is discussed. Additionally, the recent applications of these complexes as cellular probes and bioimaging reagents are described. Emphasis is put on the structural features, photophysical behavior, biomolecular interactions, cellular uptake, and intracellular localization properties of luminescent transition metal complexes.
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Cited by
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Zhao, J., Wu, W., Sun, J., & Guo, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35531d · Cited by 1,579
Anticancer cyclometalated complexes of platinum group metals and gold
Cutillas, N., Yellol, G. S., de Haro, C., Vicente, C., Rodríguez, V., & Ruiz, J. (2013) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2013.03.024 · Cited by 332
Metal-containing and related polymers for biomedical applications
Yan, Y., Zhang, J., Ren, L., & Tang, C. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00026f · Cited by 283
Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
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Metadata
- Authors
- Lo, K. K.-W., Choi, A. W.-T., & Law, W. H.-T.
- Venue
- Dalton Transactions
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 41
- Issue
- 20
- Pages
- 6021
- ISSN
- 1477-9226 (ISSN-L)
- 1477-9234
- OpenAlex
- W2025732338
- Cited by
- 386
- References
- 0
- FWCI
- 21.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lo, K. K.-W., Choi, A. W.-T., & Law, W. H.-T. (2012). Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes. Dalton Transactions. https://doi.org/10.1039/c2dt11892k
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