The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Aggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging
Abstract
Organic fluorescent probes are widely used in bioimaging and bioassays, but the notorious photobleaching hampers their applications. Encapsulation of organic dyes into nanoparticles (NPs) is an effective strategy to minimize photobleaching, but classical organic dye molecules tend to have their fluorescence quenched in aggregate states, which is termed aggregation-caused quenching (ACQ). Here we demonstrate our attempt to tackle this problem through the aggregation-induced emission (AIE) strategy. 3,4:9,10-Tetracarboxylic perylene bisimide (PBI) is a well-known organic dye with a serious ACQ problem. By attaching two tetraphenylethene (TPE) moieties to the 1,7-positions, the ACQ-characteristic PBI-derivative was converted to an AIE-characteristic molecule. The obtained PBI derivative (BTPEPBI) exhibits several advantages over classical PBI derivatives, including pronounced fluorescence enhancement in aggregate state, red to near infrared emission, and facile fabrication into uniform NPs. Studies on the staining of MCF-7 breast cancer cells and in vivo imaging of a tumor-bearing mouse model with BTPEPBI-containing NPs reveal that they are effective fluorescent probes for cancer cell and in vivo tumor diagnosis with high specificity, high photostability and good fluorescence contrast.
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Cites
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Tang, B. Z., Chen, H., Qiu, C., Kwok, H. S., Zhan, X., Liu, Y., et al. (2001) · Chemical Communications · doi:10.1039/b105159h · Cited by 8,358
Self-citationHong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
Self-citationLarge π-Aromatic Molecules as Potential Sensitizers for Highly Efficient Dye-Sensitized Solar Cells
Imahori, H., Umeyama, T., & Ito, S. (2009) · Accounts of Chemical Research · doi:10.1021/ar900034t · Cited by 1,012
Cited by
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationAggregation‐Induced Emission: The Whole Is More Brilliant than the Parts
Mei, J., Hong, Y., Lam, J. W. Y., Qin, A., Tang, Y., & Tang, B. Z. (2014) · Advanced Materials · doi:10.1002/adma.201401356 · Cited by 3,381
Self-citationPolymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging
Li, K., & Liu, B. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00014e · Cited by 987
Self-citationZhao, Z., Lam, J. W. Y., & Tang, B. Z. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm31949g · Cited by 867
Self-citationFluorescent Polymer Nanoparticles Based on Dyes: Seeking Brighter Tools for Bioimaging
Reisch, A., & Klymchenko, A. S. (2016) · Small · doi:10.1002/smll.201503396 · Cited by 634
Metadata
- Authors
- Zhao, Q., Li, K., Chen, S., Qin, A., Ding, D., Zhang, S., Liu, Y., Liu, B., Sun, J. Z., & Tang, B. Z.
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 22
- Issue
- 30
- Pages
- 15128
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W2084164454
- Cited by
- 176
- References
- 3
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- closed
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