The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?
Abstract
Aqueous solubility, protein binding and CYP450 inhibition data for compounds containing a variety of heteroaromatic and heteroaliphatic rings were analysed and compared to determine which ring types fared best and worst in these developability screens. The results suggest that certain heterorings are generally more developable than others: how this information may be used and some caveats to be borne in mind are discussed.
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Citations
Cites
The influence of drug-like concepts on decision-making in medicinal chemistry
Leeson, P. D., & Springthorpe, B. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2445 · Cited by 2,403
The productivity crisis in pharmaceutical R&D
Pammolli, F., Magazzini, L., & Riccaboni, M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3405 · Cited by 918
Matched Molecular Pairs as a Medicinal Chemistry Tool: Miniperspective
Griffen, E., Leach, A. G., Robb, G. R., & Warner, D. J. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200452d · Cited by 282
Cited by
Site-selective arene C-H amination via photoredox catalysis
Romero, N. A., Margrey, K. A., Tay, N. E., & Nicewicz, D. A. (2015) · Science · doi:10.1126/science.aac9895 · Cited by 930
The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization
Pennington, L. D., & Moustakas, D. T. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01807 · Cited by 408
Metadata
- Authors
- Ritchie, T. J., Macdonald, S. J. F., Peace, S., Pickett, S. D., & Luscombe, C. N.
- Venue
- MedChemComm
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 3
- Issue
- 9
- Pages
- 1062
- ISSN
- 2040-2503 (ISSN-L)
- 2040-2511
- OpenAlex
- W2165158819
- Cited by
- 183
- References
- 3
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
