Disease-on-a-chip: mimicry of tumor growth in mammary ducts
Open accessAbstract
We present a disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic support mimicking portions of mammary ducts. The cells from tumor nodules developing within these hemichannels are morphologically distinct from their counterparts cultured on flat surfaces. Moreover, tumor nodules cocultured with the luminal epithelium in hemichannels display a different anticancer drug sensitivity compared to nodules cocultured with the luminal epithelium on a flat surface and to monocultures of tumor nodules. The mimicry of tumor development within the epithelial environment of mammary ducts provides a framework for the design and test of anticancer therapies.
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Vidi et al. developed a breast-on-a-chip platform consisting of a breast luminal epithelium monolayer on a semicircular acrylic support to mimic cancer mammary ducts.
“In 2014, Vidi et al. developed a breast-on-a-chip platform consisting of a breast luminal epithelium monolayer on a semicircular acrylic support to mimic cancer mammary ducts218.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [218]
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References 27 · Cited by 71
Research works printed but not linked: 1
- [15]Briand P Nielsen KV Madsen MW Petersen OW Cancer Res 1996 56 2039 2044 8616848
- Authors
- Vidi, P.-A., Maleki, T., Ochoa, M., Wang, L., Clark, S. M., Leary, J. F., & Lelièvre, S. A.
- Affiliations
- Purdue University West Lafayette (US)
- Corresponding author
- Leary, James F.
- Lelièvre, Sophie A.
- ORCID
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 14
- Issue
- 1
- Pages
- 172-177
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC3880579
- OpenAlex
- W2161868478
- Cited by
- 71
- References
- 27
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 2
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Purdue e-Pubs (Purdue University System) (submittedVersion)
- Funders
- National Cancer Institute (K99CA163957)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- hemichannels, tumor microenvironment, anticancer drug sensitivity, co-culture, breast cancer
- MeSH terms
- Antineoplastic Agents, Breast Neoplasms, Cell Survival, Cells, Cultured, Epithelial Cells, Female, Humans, Coculture Techniques, Cell Culture Techniques, Integrin alpha6, Mammary Glands, Human, Microfluidic Analytical Techniques, Zonula Occludens-1 Protein
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