Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity
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Nanoparticles’ drug release kinetics can directly affect their therapeutic efficacy and toxicity.
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A decrease in drug release kinetics was also reported to be accompanied by decreased hepatotoxicity of CLS NP wortmannin.
“It was also reported that a decrease in drug release kinetics was accompanied by a decrease in the hepatotoxicity of CLS NP wortmannin.”
For nanoparticles with the same size, shape, and surface charge, slower release of docetaxel and wortmannin was accompanied by greater in vivo anti-tumor effects.
“For nanoparticles having same size, shape and surface charge a decrease in the rates of release of drugs (docetaxel, wortmannin) was accompanied by an increase in the anti-tumor effects in vivo.”
The relationship between nanoparticle drug release kinetics and the therapeutic efficacy and toxicity of delivered drugs has been previously reported.
“The relationship between the drug release kinetics from the nanoparticles and the therapeutic efficacy and toxicity of the drugs delivered using these nanoparticles has been previously reported [31].”
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References 32 · Cited by 102
Research works printed but not linked: 3
- [4]Matsumura Y Maeda H Cancer research 1986 46 6387 6392 2946403
- [23]Kanthamneni N Chaudhary A Wang J Prabhu S Int. J. Oncol 2010 37 177 185 20514409 PMC2901928
- [33]Owens Iii DE Peppas NA International Journal of Pharmaceutics 2006 307 93 102 16303268
- Authors
- Sethi, M., Sukumar, R., Karve, S., Werner, M. E., Wang, E. C., Moore, D. T., Kowalczyk, S. R., Zhang, L., & Wang, A. Z.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of California System (US)
- Corresponding author
- Wang, Andrew Z.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 6
- Issue
- 4
- Pages
- 2321-2327
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- PMC
- PMC3940272
- OpenAlex
- W1964957951
- Cited by
- 102
- References
- 32
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 9 · 2021: 7 · 2020: 12 · 2019: 5 · 2018: 10 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 4
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Lung Cancer Research Foundation
- National Institutes of Health (5u54ca151652-05, 2k12ca120780-16)
- National Cancer Institute (U54‐CA151652, K12-CA120780, K12-CA120780-01-05, R01CA178748, U54-CA151652-01)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- wortmannin, docetaxel, treatment efficacy, nanoparticle toxicity, hepatotoxicity, controlled drug release, nanotherapeutics
- MeSH terms
- Docetaxel, Wortmannin, Androstadienes, Animals, Antineoplastic Agents, Delayed-Action Preparations, Humans, Immunosuppressive Agents, Kinetics, Male, Mice, Nude, Neoplasms, Experimental, Taxoids, Mice, Nanoparticles
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