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Designing electrospun nanofiber mats to promote wound healing – a review
Open accessAbstract
Current strategies to treat chronic wounds offer limited relief to the 7.75 million patients who suffer from burns or chronic skin ulcers. Thus, as long as chronic wounds remain a global healthcare problem, the development of alternate treatments remain desperately needed. This review explores the recent strategies employed to tailor electrospun nanofiber mats towards accelerating the wound healing process. Porous nanofiber mats readily produced by the electrospinning process offer a promising solution to the management of wounds. The matrix chemistry, surface functionality, and mat degradation rate all can be fine-tuned to govern the interactions that occur at the materials-biology interface. In this review, first we briefly discuss the wound healing process and then highlight recent advances in drug release, biologics encapsulation, and antibacterial activity that have been demonstrated via electrospinning. While this versatile biomaterial has shown much progress, commercializing nanofiber mats that fully address the needs of an individual patient remains an ambitious challenge.
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Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Cited by
Recent advances in inorganic nanomaterials for wound-healing applications
Nethi, S. K., Das, S., Patra, C. R., & Mukherjee, S. (2019) · Biomaterials Science · doi:10.1039/c9bm00423h · Cited by 371
de Faria, A. F., Perreault, F., Shaulsky, E., Arias Chavez, L. H., & Elimelech, M. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01639 · Cited by 291
Engineered Nanomaterials for Infection Control and Healing Acute and Chronic Wounds
Parani, M., Lokhande, G., Singh, A., & Gaharwar, A. K. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00291 · Cited by 265
Electrospinning and electrospray of bio-based and natural polymers for biomaterials development
Soares, R. M. D., Siqueira, N. M., Prabhakaram, M. P., & Ramakrishna, S. (2018) · Materials Science and Engineering: C · doi:10.1016/j.msec.2018.08.004 · Cited by 265
Xi, Y., Ge, J., Guo, Y., Lei, B., & Ma, P. X. (2018) · ACS Nano · doi:10.1021/acsnano.8b01152 · Cited by 257
Metadata
- Authors
- Rieger, K. A., Birch, N. P., & Schiffman, J. D.
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 1
- Issue
- 36
- Pages
- 4531
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2076558842
- Cited by
- 479
- References
- 1
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Rieger, K. A., Birch, N. P., & Schiffman, J. D. (2013). Designing electrospun nanofiber mats to promote wound healing – a review. Journal of Materials Chemistry B. https://doi.org/10.1039/c3tb20795a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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