Deciphering conformational transitions of proteins by small angle X-ray scattering and normal mode analysis
Open accessAbstract
SREFLEX employs normal mode analysis for the flexible refinement of atomic models of biological macromolecules against solution scattering data, providing insight into conformational transitions.
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A multi-subunit SEC-SAXS complex containing ANGPT2147-496 and α5Calf1-2 was constructed based on contacts from co-crystal and MD studies (χ2=2.4).
“A multi-subunit SEC-SAXS complex containing ANGPT2147–496 and α5Calf1-2 was constructed (using SREFLEX; ref. 53), based on molecular contacts identified in our co-crystal and MD simulation studies (χ2 =2.4)”
From Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling (2026) · cites this paper as [53]
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Wen, B., Peng, J., Zuo, X., Gong, Q., & Zhang, Z. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.07.005 · Cited by 20 · see citing works
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Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling
Sipilä, T., Ponna, S. K., Venkatesha Murthy, A., Pink, A., Enkavi, G., Bohra, S. K., Lewna, K., Ganesh, K., Liu, Q., Korhonen, M., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci190552
- Authors
- Panjkovich, A., & Svergun, D. I.
- Affiliations
- Deutsches Elektronen-Synchrotron DESY (DE)
- Corresponding author
- Svergun, Dmitri I.
- Venue
- Physical Chemistry Chemical Physics
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 18
- Issue
- 8
- Pages
- 5707-5719
- ISSN
- 1463-9076 (ISSN-L)
- 1463-9084
- OpenAlex
- W2177561180
- Cited by
- 204
- References
- 1
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 29 · 2023: 23 · 2022: 24 · 2021: 23 · 2020: 23 · 2019: 14 · 2018: 17 · 2017: 15 · 2016: 9
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Physical Chemistry Chemical Physics (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- European Commission (BioStruct-X Grant 283570)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Advanced Physical and Chemical Molecular Interactions
- Keywords
- protein conformational change, structural flexibility, small-angle X-ray scattering, normal mode analysis, hybrid modeling, protein dynamics
- MeSH terms
- Protein Conformation, Proteins, X-Ray Diffraction, Scattering, Small Angle
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