State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

Cited by (171)

Items 101–171 of 171

1. Employing virtual screening and molecular dynamics simulations for identifying hits against the active cholera toxin
   Aditi Gangopadhyay, Hirak Jyoti Chakraborty, Abhijit Datta · 2019 · Toxicon
2. Alternative Sigma Factor of Staphylococcus aureus Interacts with the Cognate Antisigma Factor Primarily Using Its Domain 3
   Debabrata Sinha, Debasmita Sinha, Anindya Dutta, Tushar Chakraborty, Rajkrishna Mondal, Soham Seal, Asim Poddar, Subhrangsu Chatterjee, Subrata Sau · 2021 · Biochemistry
3. Small molecules for modulating the localisation of the water channel aquaporin-2—disease relevance and perspectives for targeting local cAMP signalling
   Sandrine Baltzer, Enno Klußmann · 2019 · Naunyn-Schmiedeberg s Archives of Pharmacology
4. Aza-heterocyclic frameworks through intramolecular π-system trapping of spiro- N -acyliminiums generated from isoindolinone
   Sarra Chortani, Mohamed Othman, Ata Martin Lawson, Anis Romdhane, Hichem Ben Jannet, Michael Knorr, Lukas Brieger, Carsten Strohmann B, Adam Daı̈ch · 2020 · New Journal of Chemistry
5. Abiotic Synthetic Antibodies to Target a Specific Protein Domain and Inhibit Its Function
   Qiaolian Cheng, Xiaoyang Yu, Zhouxuan Xiong, Zihao Wan, Yuxin Li, Weihua Ma, Wenfeng Tan, Mingming Liu, Kenneth J. Shea · 2022 · ACS Applied Materials & Interfaces
6. Monte Carlo simulations using PELE to identify a protein–protein inhibitor binding site and pose
   Lucía Díaz, Daniel Soler, Gary Tresadern, Christophe Buyck, Laura Pérez‐Benito, Suwipa Saen‐oon, Vı́ctor Guallar, Robert Soliva · 2020 · RSC Advances
7. Computational design of small molecular modulators of protein–protein interactions with a novel thermodynamic cycle: Allosteric inhibitors of HIV ‐1 integrase
   Qinfang Sun, R. S. K. Vijayan, Ronald M. Levy, Nanjie Deng · 2020 · Protein Science
8. Integrating Protein Interaction Surface Prediction with a Fragment-Based Drug Design: Automatic Design of New Leads with Fragments on Energy Surfaces
   Luca Torielli, Stefano Artin Serapian, Lara Mussolin, Elisabetta Moroni, Giorgio Colombo · 2022 · Journal of Chemical Information and Modeling
9. Protein-protein complexes as targets for drug discovery against infectious diseases
   Yusuf Akhter, Razak Hussain · 2019 · Advances in protein chemistry and structural biology
10. Recent Advances in β-catenin/BCL9 protein–protein Interaction Inhibitors
    Hao Zhang, Ya Bao, Chenglong Liu, Jianqi Li, Di Zhu, Qingwei Zhang · 2021 · Future Medicinal Chemistry
11. Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O
    Hao Huang, Wenning Zhu, Bin Huang, Ziyang Fu, Yuxian Xiong, Dan Cao, Yuxin Ye, Qing Chang, Wenqi Li, Long Li et al. · 2024 · Structure
12. An affinity prediction approach for the ligand of E3 ligase Cbl-b and an insight into substrate binding pattern
    Lv-Bin Hu, Xiu-Qi Hu, Qiong Zhang, Qidong You, Zhengyu Jiang · 2021 · Bioorganic & Medicinal Chemistry
13. A DNA Force Circuit for Exploring Protein‐Protein Interactions at the Single‐Molecule Level†
    Kangkang Ma, Luoan Xiong, Zhuofei Wang, Xin Hu, Lihua Qu, Xuetong Zhao, Yao Li, Zhongbo Yu · 2024 · Chinese Journal of Chemistry
14. Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools
    Liyan Zhang, Yun Chen, Sylvestre A. Bonnet · 2025 · Angewandte Chemie International Edition
15. Rapid access to reverse-turn peptidomimetics by a three-component Ugi reaction of 3,4-dihydroisoquinoline
    Arianna Rossetti, Alessandro Sacchetti, Marta Gatti, Andrea Pugliese, Gabriella Roda · 2017 · Chemistry of Heterocyclic Compounds
16. In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery
    Lesley A. Howell, Andrew Michael Beekman · 2020 · RSC Chemical Biology
17. Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers
    Shinji Nakamura, Masahiro Kamaura, Yuichiro Akao, Natsuko Nakamura, Atsushi Mizukami, Akihiko Goto, Naoki Furuyama, Nobuo Cho, Shizuo Kasai · 2021 · Bioorganic & Medicinal Chemistry
18. Bornylimidazo[1,5‑a]pyridin-3-ylidene allylic Pd catalyst with optimal electronic and steric properties for synthesis of 3,3′-disubstituted oxindoles
    Kun Wang, Tianxue Gong, Yaohuang Huang, Boyang Han, Hanxiao Yang, Pavlo O. Dral, Weiwei Fang · 2024 · Chinese Chemical Letters
19. Protein/ Hormone Based Nanoparticles as Carriers for Drugs Targeting Protein-Protein Interactions
    Ebtesam Abdullah Al-Suhaimi, Vijaya Ravinayagam, B. Rabindran Jermy, Mohamad Tarhini, Abdelhamid Elaı̈ssari · 2019 · Current Topics in Medicinal Chemistry
20. Indolylglycines Backbones in the Synthesis of Enantiopure 3,3‐Spiroindolenines, Indolyl Tetracyclic Hemiaminals, and 3‐Indolyl‐maleimides Frameworks
    Jozef Markus, Branislav Ferko, Dušan Berkeš, Ján Moncóľ, Ata Martin Lawson, Mohamed Othman, Adam Daı̈ch · 2019 · European Journal of Organic Chemistry
21. Reversible regulation of esterase activity via host–guest molecular recognition at the nanoparticle surface
    Meenakshi Pahwa, Manik Sharma, Shafeekh Kulathinte Meethal, Sarit S. Agasti · 2020 · Bulletin of Materials Science
22. Acenaphthoimidazolylidene‐ligated chiral oxazoline palladacycles: synthesis, structure, and application in intramolecular α ‐arylation of amides towards 3,3′‐disubstituted oxindoles
    Hanxiao Yang, Kun Wang, Weiwei Fang · 2023 · Asian Journal of Organic Chemistry
23. Where to next in the evolution of in silico design of modulators targeting protein–protein interactions?
    Yibo Wang, Xiaohui Wang · 2023 · Expert Opinion on Drug Discovery
24. Divergent, C–C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates
    Wenqing Xu, Lauren E. Brown, John A. Jr. Porco · 2021 · The Journal of Organic Chemistry
25. Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment
    Siddhant Tripathi, Yashika Sharma, Dileep Kumar · 2024 · Protein and Peptide Letters
26. The study of EGFR-ligand complex electron property relationship with biological activity
    Prateek Pathak, Vladislav Naumovich, Maria Grishina, Vladimir Potemkin · 2020 · Journal of Biomolecular Structure and Dynamics
27. Fragment hopping protocol for the design of small-molecule protein–protein interaction inhibitors
    Shelby R. Kell, Zhen Wang, Haitao Ji · 2022 · Bioorganic & Medicinal Chemistry
28. Recent advances and challenges in peptide drug development
    N.K. Hemanth Kumar, K. Poornachandra Rao, Rakesh Somashekaraiah, Shobha Jagannath, M.Y. Sreenivasa · 2023 · Elsevier eBooks
29. Programming interchangeable and reversible heterooligomeric protein self-assembly using a bifunctional ligand
    Su-young Son, Woon Ju Song · 2024 · Chemical Science
30. Molecular dynamics investigations for the prediction of molecular interaction of cauliflower mosaic virus transmission helper component protein complex with Myzus persicae stylet’s cuticular protein and its docking studies with annosquamosin-A encapsulated in nano-porous Silica
    D. Jeya Sundara Sharmila, J. Jino Blessy, Vinohar Stephen Rapheal, K. S. Subramanian · 2019 · VirusDisease
31. Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14
    Percy S. Agogo-Mawuli, Isra Sadiya, Tigran M. Abramyan, Dustin E. Bosch, Kyle A. Emmitte, Luis M. Colón-Pérez, Mickey Kosloff, David Peter Siderovski · 2025 · Journal of Biological Chemistry
32. Tryptophan association in water driven by charge-transfer interactions with electron-deficient aromatic haptens
    Estela Sánchez‐Santos, José J. Garrido‐González, Ligzajaya F. Rodríguez-Sahagún, Asmaa Habib, Angel Luis Fuentes de Arriba, Francisca Sanz B, Eva M. Martín del Valle, Joaquin Rodriguez Moran, Victoria Alcázar · 2022 · Organic & Biomolecular Chemistry
33. Drug Design Methods to Regulate Protein–Protein Interactions
    Krishna Mohan Poluri, Khushboo Gulati, Deepak Kumar Tripathi, Nupur Nagar · 2023 · Springer eBooks
34. A biocatalytic peptidobiosensing molecular bridge for detecting osteosarcoma marker protein
    Pengwei Jing, Ying Wang, Weixue Sun, Guishi Li, Zuofu Zhang, Qiang Xu, Hao Li · 2023 · Frontiers in Chemistry
35. High-Throughput Screening in the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions
    Chunlin Zhuang, Chunquan Sheng · 2018 · Springer eBooks
36. Foldamers as Inhibitors of Aberrant Protein–Protein Interactions
    Nicholas H. Stillman, Ryan A. Dohoney, Charles Zuwu Baysah, Sunil Kumar · 2025 · Wiley eBooks
37. Carbene Footprinting Directs Design of Genetically Encoded Proximity-Reactive Protein Binders
    Hui Ye, Yinxue Zhu, Ying Kong, Hongtao Wen, Wenjie Lu, Dexiang Wang, Shuo Tang, Mengru Zhan, Gaoyuan Lu, Chang Shao et al. · 2024 · Analytical Chemistry
38. Protein Docking and Drug Design
    Aditi Gangopadhyay, Hirak Jyoti Chakraborty, Abhijit Datta · 2019 · IGI Global eBooks
39. Unity Is Strength: The Mutual Alliance between CFTR and SLC26A6 as Therapeutic Opportunity in Cystic Fibrosis
    Marilena Pariano, Cinzia Antognelli, Luigina R. Romani, Claudio Costantini · 2024 · Pharmaceuticals
40. How Do DNA Molecular Springs Modulate Protein–Protein Interactions: Experimental and Theoretical Results
    Kecheng Zhang, Jingze Duan, Cong Li, Chen Song, Zhixing Chen · 2024 · Biochemistry
41. Macromolecular crowding effect on the β-galactosidase cascade reaction under multivalency and chain overlapping conditions of glycopolymers
    Li Wen, Jinxia Zheng, Z Ke, Jian Dong · 2025 · International Journal of Biological Macromolecules
42. Protein-Protein Interactions (PPIs) as an Alternative to Targeting the ATP Binding Site of Kinase
    Sailu Sarvagalla, Mohane Selvaraj Coumar · 2016 · Advances in medical technologies and clinical practice book series
43. Overview of Protein-Protein Interactions and Small-Molecule Inhibitors Under Clinical Development
    Guoqiang Dong, Chunquan Sheng · 2018 · Springer eBooks
44. Bioactive interactions in food and natural extracts
    Sofia Moco, Denís Barron · 2017
45. Protein Docking and Drug Design
    Aditi Gangopadhyay, Hirak Jyoti Chakraborty, Abhijit Datta · 2017 · Advances in bioinformatics and biomedical engineering book series
46. Deubiquitinase Otubain 1 as a Cancer Therapeutic Target
    Dong‐Eun Kim, Seon Min Woo, Taeg Kyu Kwon · 2020 · JoLS Journal of Life Sciences
47. Understanding and drugging the Bcl-2 transmembrane interactome for tumor treatment
    Estefanía Lucendo · 2020
48. High-Throughput Screening to Identify Inhibitors of SSB-Protein Interactions
    Andrew F. Voter · 2021 · Methods in molecular biology
49. Faculty Opinions recommendation of Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin.
    Cigall Kadoch · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
50. Protein-Protein Interactions (PPIs) as an Alternative to Targeting the ATP Binding Site of Kinase
    Sailu Sarvagalla, Mohane Selvaraj Coumar · 2016 · IGI Global eBooks
51. Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate
    Junyang Liu, Shoubin Tang, Jia‐Lei Yan, Tao Ye · 2023 · Molecules
52. Rational Design of Anticancer Therapeutics
    Debarupa Dutta Chakraborty, Prithviraj Chakraborty · 2024
53. Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools
    Liyan Zhang, Yun Chen, Sylvestre A. Bonnet · 2025 · Angewandte Chemie
54. A yeast-based assay to screen protein-protein interaction modulators
    Aswani Sudevan · 2021
55. Identification of potential allosteric inhibitors-modulators for the heterodimer CDC34-UBC protein-protein complex
    Hemchandra Deka, Heba Taha M. Abdelghani, Aditi Gangopadhyay, Atul Darasing Pawar, Pritee Chunarkar Patil, Shovonlal Bhowmick · 2026 · 3 Biotech
56. Structural bioinformatics-based targeting of Epstein-Barr virus BPLF1 deubiquitinase activity against EBV infection and in-vitro validation
    Atta Ullah, Saeed Ullah, Najeeb Ur Rehman, Mesaik M. Ahmed, Hanan A. Ogaly, Sobia Ahsan Halim, Ajmal Khan, Ahmed Al‐Harrasi · 2026 · 3 Biotech
57. Protein–protein interaction inhibitors in the human proteome: lessons from 117 targeted interactions
    Ellie Hyde, Andrew Michael Beekman · 2026 · RSC Medicinal Chemistry
58. Synthetic Protein Mimetic Based Therapies for Neurodegeneration
    Nicholas H. Stillman · 2025
59. Targeting Aberrant Protein-Protein Interactions in Cancer and Neurodegenerative Diseases
    Tyler D. Ball · 2025
60. Artificial Synthetic Protein Mimetics As Pathology-Targeted Therapeutics
    Ryan A. Dohoney · 2026
61. Self-assembly of surface layer protein SbsC from Geobacillus stearothermophilus and common principles of Bacilli S-layers
    Christoph Grininger, Lavinia Gambelli, Anđela Đordić, Markus Eder, Christoph Buhlheller, Theo Sagmeister, Gustav Oberdorfer, Janet Vonck, Uwe B. Sleytr, Walter Keller et al. · 2026 · Journal of Biological Chemistry
62. Exploring glycopentamides from Glycosmis pentaphylla as CDK4 inhibitors: a computational study
    Đoàn Lê Bình, Trần Thị Phương Thảo, Nguyễn Trâm Anh, Pham Trong Phuc, Ngu Thi Tra Giang, Nguyen Thi Diem Hang, Nguyen Xuan Ha, Phan Thi Thuy · 2026 · Journal of the Iranian Chemical Society
63. Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
    Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Xia Chen, Peiyi Wang, Jian-Mei Gao, Qihai Gong · 2026 · Advanced Science
64. BindingDB Entry 50001714: Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases.
    BindingDB · 2020 · UC San Diego
65. BindingDB Entry 50049305: Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization.
    BindingDB · 2019 · UC San Diego
66. BindingDB Entry 50018346: Computational methods-guided design of modulators targeting protein-protein interactions (PPIs).
    BindingDB · 2024 · UC San Diego
67. BindingDB Entry 50020171: Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
    BindingDB · 2024 · UC San Diego
68. BindingDB Entry 50009297: Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases.
    BindingDB · 2021 · UC San Diego
69. BindingDB Entry 50018333: Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.
    BindingDB · 2024 · UC San Diego
70. BindingDB Entry 50013903: An affinity prediction approach for the ligand of E3 ligase Cbl-b and an insight into substrate binding pattern.
    BindingDB · 2022 · UC San Diego
71. BindingDB Entry 50021293: Cyclic Peptide Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Design, Synthesis, and In Vivo Treatment of Acute Lung Injury.
    BindingDB · 2025 · UC San Diego