Genome scale models of yeast: towards standardized evaluation and consistent omic integration
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We review genome scale models of yeast, how are they typically evaluated, and how can they be integrated with omic data.
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Proteomics data have so far mostly been indirectly combined with genome-scale metabolic models by correlating protein levels to the corresponding fluxes.
“Proteomics data have so far mostly been indirectly combined with GEMs by correlating protein levels to the corresponding fluxes (Sánchez & Nielsen, 2015).”
From Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints (2017) · cites this paper as Sánchez & Nielsen, 2015
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- D. Botstein, S. A. Chervitz and J. M. Cherry, Science, 1997, 277, 1259-1260.
- E. J. Steen, R. Chan, N. Prasad, S. Myers, C. J. Petzold, A. Redding, M. Ouellet and J. D. Keasling, Microb. Cell Fact., 2008, 7, 36.
- J. Zaldivar, J. Nielsen and L. Olsson, Appl. Microbiol. Biotechnol., 2001, 56, 17-34.
- D. K. Ro, E. M. Paradise, M. Ouellet, K. J. Fisher, K. L. Newman, J. M. Ndungu, K. A. Ho, R. A. Eachus, T. S. Ham, J. Kirby, M. C. Y. Chang, S. T. Withers, Y. Shiba, R. Sarpong and J. D. Keasling, Nature, 2006, 440, 940-943.
- S. Yamano, T. Ishii, M. Nakagawa, H. Ikenaga and N. Misawa, Biosci., Biotechnol., Biochem., 1994, 58, 1112-1114.
- E. J. Kerkhoven, P. J. Lahtvee and J. Nielsen, FEMS Yeast Res., 2014, 15, 1-13.
- A. Bordbar, J. M. Monk, Z. A. King and B. Ø. Palsson, Nat. Rev. Genet., 2014, 15, 107-120.
- M. A. Oberhardt, B. Ø. Palsson and J. A. Papin, Mol. Syst. Biol., 2009, 5, 320.
- G. Liu, A. Marras and J. Nielsen, Quant. Biol., 2014, 2, 30-46.
- I. Nookaew, R. Olivares-Herna ´ndez, S. Bhumiratana and J. Nielsen, Methods Mol. Biol., 2011, 759, 445-463.
- T. O ¨sterlund, I. Nookaew and J. Nielsen, Biotechnol. Adv., 2012, 30, 979-988.
- C. Bro, B. Regenberg, J. Fo ¨rster and J. Nielsen, Metab. Eng., 2006, 8, 102-111.
- D. Byrne, A. Dumitriu and D. Segre `, BMC Syst. Biol., 2012, 6, 127.
- B. K. S. Chung, M. Lakshmanan, M. Klement, B. Mohanty and D. Y. Lee, Chem. Eng. Sci., 2013, 103, 100-108.
- C. Y. Ng, M.-Y. Jung, J. Lee and M.-K. Oh, Microb. Cell Fact., 2012, 11, 68.
- N. C. Duarte, M. J. Herrgård and B. Ø. Palsson, Genome Res., 2004, 14, 1298-1309.
- L. Kuepfer, U. Sauer and L. M. Blank, Genome Res., 2005, 15, 1421-1430.
- I. Nookaew, M. C. Jewett, A. Meechai, C. Thammarongtham, K. Laoteng, S. Cheevadhanarak, J. Nielsen and S. Bhumiratana, BMC Syst. Biol., 2008, 2, 71.
- M. L. Mo, B. Ø. Palsson and M. J. Herrgård, BMC Syst. Biol., 2009, 3, 37.
- M. J. Herrgård, N. Swainston, P. D. Dobson, W. B. Dunn, K. Y. Arga, M. Arvas, N. Blu ¨thgen, S. Borger, R. Costenoble, M. Heinemann, M. Hucka, N. Le Nove `re, P. Li, W. Liebermeister, M. L. Mo, A. P. Oliveira, D. Petranovic, S. Pettifer, E. Simeonidis, K. Smallbone, I. Spasic ´, D. Weichart, R. Brent, D. S. Broomhead, H. V Westerhoff, B. Kirdar, M. Penttila ¨, E. Klipp, B. Ø. Palsson, U. Sauer, S. G. Oliver, P. Mendes, J. Nielsen and D. B. Kell, Nat. Biotechnol., 2008, 26, 1155-1160.
- P. D. Dobson, K. Smallbone, D. Jameson, E. Simeonidis, K. Lanthaler, P. Pir, C. Lu, N. Swainston, W. B. Dunn, P. Fisher, D. Hull, M. Brown, O. Oshota, N. J. Stanford, D. B. Kell, R. D. King, S. G. Oliver, R. D. Stevens and P. Mendes, BMC Syst. Biol., 2010, 4, 145.
- B. D. Heavner, K. Smallbone, B. Barker, P. Mendes and L. P. Walker, BMC Syst. Biol., 2012, 6, 1.
- H. W. Aung, S. A. Henry and L. P. Walker, Ind. Biotechnol., 2013, 9, 215-228.
- A. R. Zomorrodi and C. D. Maranas, BMC Syst. Biol., 2010, 4, 178.
- T. O ¨sterlund, I. Nookaew, S. Bordel and J. Nielsen, BMC Syst. Biol., 2013, 7, 36.
- P. Ghaffari, A. Mardinoglu, A. Asplund, S. Shoaie, C. Kampf, M. Uhlen and J. Nielsen, Sci. Rep., 2015, 5, 8183.
- B. D. Heavner and N. D. Price, in preparation. 30 A. Wagner and D. A. Fell, Proc. Biol. Sci., 2001, 268, 1803-1810.
- G. Del Rio, D. Koschu ¨tzki and G. Coello, BMC Syst. Biol., 2009, 3, 102.
- T. Rubina, M. Mednis and E. Stalidzans, CINTI 2013 -14th IEEE Int. Symp. Comput. Intell. Informatics, Proc., 2013, 411-418.
- D. Vitkup, P. Kharchenko and A. Wagner, Genome Biol., 2006, 7, R39.
- Y. Assenov, F. Ramı ´rez, S. E. Schelhorn, T. Lengauer and M. Albrecht, Bioinformatics, 2008, 24, 282-284.
- C. H. Chin, S. H. Chen, H. H. Wu, C. W. Ho, M. T. Ko and C. Y. Lin, BMC Syst. Biol., 2014, 8, S11.
- M. Kanehisa, S. Goto, Y. Sato, M. Kawashima, M. Furumichi and M. Tanabe, Nucleic Acids Res., 2014, 42, 199-205.
- R. Caspi, T. Altman, R. Billington, K. Dreher, H. Foerster, C. A. Fulcher, T. A. Holland, I. M. Keseler, A. Kothari, A. Kubo, M. Krummenacker, M. Latendresse, L. A. Mueller, Q. Ong, S. Paley, P. Subhraveti, D. S. Weaver, D. Weerasinghe, P. Zhang and P. D. Karp, Nucleic Acids Res., 2014, 42, 459-471.
- R. Mahadevan and C. H. Schilling, Metab. Eng., 2003, 5, 264-276.
- J. D. Orth, I. Thiele and B. Ø. Palsson, Nat. Biotechnol., 2010, 28, 245-248.
- A. Varma and B. Ø. Palsson, Appl. Environ. Microbiol., 1994, 60, 3724-3731.
- J. Fo ¨rster, I. Famili, B. Ø. Palsson and J. Nielsen, OMICS, 2003, 7, 193-202.
- G. Basler, Methods Mol. Biol., 2015, 1279, 183-204.
- D. Segre `, D. Vitkup and G. M. Church, Proc. Natl. Acad. Sci.
- U. S. A., 2002, 99, 15112-15117.
- T. Shlomi, O. Berkman and E. Ruppin, Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 7695-7700.
- G. Giaever, A. M. Chu, L. Ni, C. Connelly, L. Riles, S. Ve ´ronneau, S. W. Dow, A. Lucau-Danila, K. Anderson, B. Andre ´, A. P. Arkin, A. Astromoff, M. El Bakkoury, R. Bangham, R. Benito, S. Brachat, S. Campanaro, M. Curtiss, K. Davis, A. M. Deutschbauer, K.-D. Entian, P. Flaherty, F. Foury, D. J. Garfinkel, M. Gerstein, D. Gotte, U. Gu ¨ldener, J. H. Hegemann, S. Hempel, Z. S. Herman, D. F. Jaramillo, D. E. Kelly, S. L. Kelly, P. Ko ¨tter, D. LaBonte, D. C. Lamb, N. Lan, H. Liang, H. Liao, L. Liu, C. Luo, M. Lussier, R. Mao, P. Menard, S. L. Ooi, J. L. Revuelta, C. J. Roberts, M. Rose, P. Ross-Macdonald, B. Scherens, G. Schimmack, B. Shafer, D. D. Shoemaker, S. Sookhai-Mahadeo, R. K. Storms, J. N. Strathern, G. Valle, M. Voet, G. Volckaert, C. Wang, T. R. Ward, J. Wilhelmy, E. A. Winzeler, Y. Yang, G. S. Yen, E. Youngman, K. Yu, H. Bussey, J. D. Boeke, M. Snyder, P. Philippsen, R. W. Davis and M. Johnston, Nature, 2002, 418, 387-391.
- L. M. Steinmetz, C. Scharfe, A. M. Deutschbauer, D. Mokranjac, Z. S. Herman, T. Jones, A. M. Chu, G. Giaever, H. Prokisch, P. J. Oefner and R. W. Davis, Nat. Genet., 2002, 31, 400-404.
- E. A. Winzeler, D. D. Shoemaker, A. Astromoff, H. Liang, K. Anderson, B. Andre, R. Bangham, R. Benito, J. D. Boeke, H. Bussey, A. M. Chu, C. Connelly, K. Davis, F. Dietrich, S. W. Dow, M. El Bakkoury, F. Foury, S. H. Friend, E. Gentalen, G. Giaever, J. H. Hegemann, T. Jones, M. Laub, H. Liao, N. Liebundguth, D. J. Lockhart, A. Lucau-Danila, M. Lussier, N. M'Rabet, P. Menard, M. Mittmann, C. Pai, C. Rebischung, J. L. Revuelta, L. Riles, C. J. Roberts, P. Ross-MacDonald, B. Scherens, M. Snyder, S. Sookhai-Mahadeo, R. K. Storms, S. Ve ´ronneau, M. Voet, G. Volckaert, T. R. Ward, R. Wysocki, G. S. Yen, K. Yu, K. Zimmermann, P. Philippsen, M. Johnston and R. W. Davis, Science, 1999, 285, 901-906.
- S. R. Engel, R. Balakrishnan, G. Binkley, K. R. Christie, M. C. Costanzo, S. S. Dwight, D. G. Fisk, J. E. Hirschman, B. C. Hitz, E. L. Hong, C. J. Krieger, M. S. Livstone, S. R. Miyasato, R. S. Nash, R. Oughtred, J. Park, M. S. Skrzypek, S. Weng, E. D. Wong, K. Dolinski, D. Botstein and J. M. Cherry, Nucleic Acids Res., 2009, 38, 1-4.
- J. M. Cherry, E. L. Hong, C. Amundsen, R. Balakrishnan, G. Binkley, E. T. Chan, K. R. Christie, M. C. Costanzo, S. S. Dwight, S. R. Engel, D. G. Fisk, J. E. Hirschman, B. C. Hitz, K. Karra, C. J. Krieger, S. R. Miyasato, R. S. Nash, J. Park, M. S. Skrzypek, M. Simison, S. Weng and E. D. Wong, Nucleic Acids Res., 2012, 40, 1-6.
- M. Costanzo, A. Baryshnikova, J. Bellay, Y. Kim, E. D. Spear, C. S. Sevier, H. Ding, J. L. Y. Koh, K. Toufighi, S. Mostafavi, J. Prinz, R. P. St Onge, B. VanderSluis, T. Makhnevych, F. J. Vizeacoumar, S. Alizadeh, S. Bahr, R. L. Brost, Y. Chen, M. Cokol, R. Deshpande, Z. Li, Z. Y. Lin, W. Liang, M. Marback, J. Paw, B. J. San Luis, E. Shuteriqi, A. H. Y. Tong, N. Van Dyk, I. M. Wallace, J. A. Whitney, M. T. Weirauch, G. Zhong, H. Zhu, W. A. Houry, M. Brudno, S. Ragibizadeh, B. Papp, C. Pa ´l, F. P. Roth, G. Giaever, C. Nislow, O. G. Troyanskaya, H. Bussey, G. D. Bader, A. C. Gingras, Q. D. Morris, P. M. Kim, C. A. Kaiser, C. L. Myers, B. J. Andrews and C. Boone, Science, 2010, 327, 425-431.
- E. S. Snitkin, A. M. Dudley, D. M. Janse, K. Wong, G. M. Church and D. Segre `, Genome Biol., 2008, 9, R140.
- B. Vandersluis, D. C. Hess, C. Pesyna, E. W. Krumholz, T. Syed, B. Szappanos, C. Nislow, B. Papp, O. G. Troyanskaya, C. L. Myers and A. A. Caudy, Genome Biol., 2014, 15, R64.
- D. McCloskey, B. Ø. Palsson and A. M. Feist, Mol. Syst. Biol., 2013, 9, 661.
- E. Gonçalves, J. Bucher, A. Ryll, J. Niklas, K. Mauch, S. Klamt, M. Rocha and J. Saez-Rodriguez, Mol. BioSyst., 2013, 9, 1576-1583.
- R. Saha, A. Chowdhury and C. D. Maranas, Curr. Opin. Biotechnol., 2014, 29, 39-45.
- A. S. Blazier and J. A. Papin, Front. Physiol., 2012, 3, 299.
- A. Hoppe, Metabolites, 2012, 2, 614-631.
- M. Åkesson, J. Fo ¨rster and J. Nielsen, Metab. Eng., 2004, 6, 285-293.
- J. L. Hjersted and M. A. Henson, IET Syst. Biol., 2009, 3, 167-179.
- B. J. Sa ´nchez, J. R. Pe ´rez-Correa and E. Agosin, Metab. Eng., 2014, 25, 159-173.
- S. A. Becker and B. Ø. Palsson, PLoS Comput. Biol., 2008, 4, e1000082.
- H. Zur, E. Ruppin and T. Shlomi, Bioinformatics, 2010, 26, 3140-3142.
- E. Almaas, B. Kova ´cs, T. Vicsek, Z. N. Oltvai and A.-L. Baraba ´si, Nature, 2004, 427, 839-843.
- Y. Bilu, T. Shlomi, N. Barkai and E. Ruppin, PLoS Comput. Biol., 2006, 2, 0932-0938.
- O. Rokhlenko, T. Shlomi, R. Sharan, E. Ruppin and R. Y. Pinter, Bioinformatics, 2007, 23, 2139-2146.
- S. Bordel, R. Agren and J. Nielsen, PLoS Comput. Biol., 2010, 6, 16.
- J. L. Martı ´nez, S. Bordel, K. K. Hong and J. Nielsen, FEMS Yeast Res., 2014, 14, 654-662.
- This journal is © The Royal Society of Chemistry 2015 Integr. Biol., 2015, 7, 846--858 | 857
- C. J. Kennedy, P. M. Boyle, Z. Waks and P. A. Silver, Genetics, 2009, 183, 385-397.
- P. A. Jensen and J. A. Papin, Bioinformatics, 2011, 27, 541-547.
- R. J. P. Van Berlo, D. de Ridder, J. M. Daran, P. A. S. Daran- Lapujade, B. Teusink and M. J. T. Reinders, IEEE/ACM Trans. Comput. Biol. Bioinf., 2011, 8, 206-216.
- A. Salehzadeh-Yazdi, Y. Asgari, A. A. Saboury and A. Masoudi- Nejad, PLoS One, 2014, 9, e111686.
- J. Kim and J. L. Reed, Genome Biol., 2012, 13, R78.
- D. Lee, K. Smallbone, W. B. Dunn, E. Murabito, C. L. Winder, D. B. Kell, P. Mendes and N. Swainston, BMC Syst. Biol., 2012, 6, 1.
- S. Rossell, M. A. Huynen and R. A. Notebaart, PLoS Comput. Biol., 2013, 9, e1002988.
- H. S. Song, J. Reifman and A. Wallqvist, PLoS One, 2014, 9, e112524.
- M. J. Herrgård, B. S. Lee, V. Portnoy and B. Ø. Palsson, Genome Res., 2006, 16, 627-635.
- P. A. Jensen, K. A. Lutz and J. A. Papin, BMC Syst. Biol., 2011, 5, 147.
- S. Chandrasekaran and N. D. Price, PLoS Comput. Biol., 2013, 9, e1003370.
- J. M. Savinell and B. Ø. Palsson, J. Theor. Biol., 1992, 154, 421-454.
- E. Reznik, P. Mehta and D. Segre `, PLoS Comput. Biol., 2013, 9, e1003195.
- A. Wagner, R. Zarecki, L. Reshef, C. Gochev, R. Sorek, U. Gophna and E. Ruppin, Proc. Natl. Acad. Sci. U. S. A., 2013, 110, 19166-19171.
- K. Yizhak, O. Gabay, H. Cohen and E. Ruppin, Nat. Com- mun., 2013, 4, 2632.
- B. Barker, N. Sadagopan, Y. Wang, K. Smallbone, M. R. Christopher, H. Xi, J. W. Locasale and Z. Gu, Mol. Networks, 2014, arXiv:1404.4755. · arXiv
- D. Machado and M. J. Herrgård, PLoS Comput. Biol., 2014, 10, e1003580.
- K. R. Patil and J. Nielsen, Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 2685-2689.
- A. P. Oliveira, K. R. Patil and J. Nielsen, BMC Syst. Biol., 2008, 2, 17.
- R. Usaite, K. R. Patil, T. Grotkjær, J. Nielsen and B. Regenberg, Appl. Environ. Microbiol., 2006, 72, 6194-6203.
- S. L. Westergaard, A. P. Oliveira, C. Bro, L. Olsson and J. Nielsen, Biotechnol. Bioeng., 2007, 96, 134-145.
- D. Cimini, K. R. Patil, C. Schiraldi and J. Nielsen, BMC Syst. Biol., 2009, 3, 17.
- R. Usaite, M. C. Jewett, A. P. Oliveira, J. R. Yates, L. Olsson and J. Nielsen, Mol. Syst. Biol., 2009, 5, 319.
- P. Chumnanpuen, J. Zhang, I. Nookaew and J. Nielsen, Mol. Genet. Genomics, 2012, 287, 541-554.
- P. Chumnanpuen, I. Nookaew and J. Nielsen, BMC Syst. Biol., 2013, 7, S7.
- W. A. Bryant, M. J. E. Sternberg and J. W. Pinney, BMC Syst. Biol., 2013, 7, 26.
- M. C. Jewett, C. T. Workman, I. Nookaew, F. A. Pizarro, E. Agosin, L. I. Hellgren and J. Nielsen, G3, 2013, 3, 1979-1995.
- E. Lindfors, P. Jouhten, M. Oja, E. Rintala, M. Ores ˇic ˇand M. Penttila ¨, BMC Syst. Biol., 2014, 8, 16.
- P. Kharchenko, D. Vitkup and G. M. Church, Bioinfor- matics, 2004, 20, 178-185.
- P. Kharchenko, L. Chen, Y. Freund, D. Vitkup and G. M. Church, BMC Bioinf., 2006, 7, 177.
- K. Y. Teh and A. E. Lutz, J. Biotechnol., 2010, 147, 80-87.
- D. Segre `, A. Deluna, G. M. Church and R. Kishony, Nat. Genet., 2005, 37, 77-83. 100
- X. He, W. Qian, Z. Wang, Y. Li and J. Zhang, Nat. Genet., 2010, 42, 272-276. 101
- E. S. Snitkin and D. Segre `, PLoS Genet., 2011, 7, e1001294. 102
- R. Harrison, B. Papp, C. Pa ´l, S. G. Oliver and D. Delneri, Proc. Natl. Acad. Sci. U. S. A., 2007, 104, 2307-2312. 103
- B. Szappanos, K. Kova ´cs, B. Szamecz, F. Honti, M. Costanzo, A. Baryshnikova, G. Gelius-Dietrich, M. J. Lercher, M. Jelasity, C. L. Myers, B. J. Andrews, C. Boone, S. G. Oliver, C. Pa ´l and B. Papp, Nat. Genet., 2011, 43, 656-662. 104
- L. Xu, B. Barker and Z. Gu, Proc. Natl. Acad. Sci. U. S. A., 2012, 109, 10420-10425.
- A. R. Brochado, S. Andrejev, C. D. Maranas and K. R. Patil, PLoS Comput. Biol., 2012, 8, e1002758. 106
- R. Costenoble, P. Picotti, L. Reiter, R. Stallmach, M. Heinemann, U. Sauer and R. Aebersold, Mol. Syst. Biol., 2011, 7, 464. 107
- A. Ku ¨mmel, S. Panke and M. Heinemann, Mol. Syst. Biol., 2006, 2, 2006.0034. 109
- N. Zamboni, A. Ku ¨mmel and M. Heinemann, BMC Bioinf., 2008, 9, 199. 110
- J. C. Ewald, T. Matt and N. Zamboni, Mol. BioSyst., 2013, 9, 440-446.
- S. J. Jol, A. Ku ¨mmel, M. Terzer, J. Stelling and M. Heinemann, PLoS Comput. Biol., 2012, 8, 1-9.
- V. S. Martı ´nez, L. E. Quek and L. K. Nielsen, Biophys. J., 2014, 107, 493-503. 113
- K. Smallbone and P. Mendes, Ind. Biotechnol., 2013, 9, 179-184.
- N. J. Stanford, T. Lubitz, K. Smallbone, E. Klipp, P. Mendes and W. Liebermeister, PLoS One, 2013, 8, e79195. 115
- K. C. Soh, L. Miskovic and V. Hatzimanikatis, FEMS Yeast Res., 2012, 12, 129-143. 116
- C. M. Paget, J. M. Schwartz and D. Delneri, Mol. Ecol., 2014, 23, 5241-5257. 117
- J. L. Hjersted, M. A. Henson and R. Mahadevan, Biotechnol. Bioeng., 2007, 97, 1190-1204. 118
- R. Eslamloueyan and P. Setoodeh, Chem. Eng. Commun., 2011, 198, 1309-1338.
- A. Ghosh, H. Zhao and N. D. Price, PLoS One, 2011, 6, e27316. 120
- J. Zanghellini, K. Natter, C. Jungreuthmayer, A. Thalhammer, C. F. Kurat, G. Gogg-Fassolter, S. D. Kohlwein and H. H. Von Gru ¨nberg, FEBS J., 2008, 275, 5552-5563. 121
- T. J. Hanly and M. A. Henson, Biotechnol. Bioeng., 2011, 108, 376-385. 122
- J. T. Leppa ¨vuori, M. M. Domach and L. T. Biegler, Ind. Eng. Chem. Res., 2011, 50, 12080-12091.
- F. A. Vargas, F. A. Pizarro, J. R. Pe ´rez-Correa and E. Agosin, BMC Syst. Biol., 2011, 5, 75. 124
- T. J. Hanly, M. Urello and M. A. Henson, Appl. Microbiol. Biotechnol., 2012, 93, 2529-2541. 125
- P. Jouhten, M. Wiebe and M. Penttila ¨, FEBS J., 2012, 279, 3338-3354. 126
- T. J. Hanly and M. A. Henson, Biotechnol. Biofuels, 2013, 6, 44. 127
- K. Ho ¨ffner, S. M. Harwood and P. I. Barton, Biotechnol. Bioeng., 2013, 110, 792-802. 128
- J. A. Gomez, K. Ho ¨ffner and P. I. Barton, BMC Bioinf., 2014, 15, 409. 129
- T. J. Hanly and M. A. Henson, Biotechnol. Bioeng., 2014, 111, 272-284. 130
- P. K. Lisha and D. Sarkar, Bioprocess Biosyst. Eng., 2014, 37, 617-627. 131
- P. K. Lisha and D. Sarkar, Biotechnol. Res. Int., 2015, 2015, 238082.
- A. M. Willemsen, D. M. Hendrickx, H. C. J. Hoefsloot, M. M. W. B. Hendriks, S. A. Wahl, B. Teusink, A. K. Smilde and A. H. C. Van Kampen, Mol. BioSyst., 2015, 11, 137-145.
- A. Chowdhury, A. R. Zomorrodi and C. D. Maranas, PLoS Comput. Biol., 2014, 10, e1003487. 134
- K. Smallbone, E. Simeonidis, N. Swainston and P. Mendes, BMC Syst. Biol., 2010, 4, 6. 135
- A. F. Villaverde, D. Henriques, K. Smallbone, S. Bongard, J. Schmid, D. Cicin-Sain, A. Crombach, J. Saez-Rodriguez, K. Mauch, E. Balsa-Canto, P. Mendes, J. Jaeger and J. R. Banga, BMC Syst. Biol., 2015, 9, 8. 136
- R. Mahadevan, J. S. Edwards and F. J. Doyle III, Biophys. J., 2002, 83, 1331-1340. 137
- B. Teusink, J. Passarge, C. A. Reijenga, E. Esgalhado, C. C. Van Der Weijden, M. Schepper, M. C. Walsh, B. M. Bakker, K. Van Dam, H. V Westerhoff and J. L. Snoep, Eur. J. Biochem., 2000, 267, 5313-5329. 138 E. Klipp, Yeast, 2007, 24, 943-959. 139
- C. Reder, J. Theor. Biol., 1988, 135, 175-201. 140
- L. Miskovic and V. Hatzimanikatis, Trends Biotechnol., 2010, 28, 391-397.
- Q. K. Beg, A. Vazquez, J. Ernst, M. A. de Menezes, Z. Bar- Joseph, A. L. Baraba ´si and Z. N. Oltvai, Proc. Natl. Acad. Sci.
- U. S. A., 2007, 104, 12663-12668.
- M. J. Van Hoek and R. M. Merks, BMC Syst. Biol., 2012, 6, 22. 143
- M. Celton, A. Goelzer, C. Camarasa, V. Fromion and S. Dequin, Metab. Eng., 2012, 14, 366-379. 144
- D. Dikicioglu, S. Oc, B. M. Rash, W. B. Dunn, P. Pir, D. B. Kell, B. Kirdar and S. G. Oliver, Mol. BioSyst., 2014, 10, 93-102. 145
- B. J. Stewart, A. Navid, K. W. Turteltaub and G. Bench, Anal. Chem., 2010, 82, 9812-9817.
- R. M. Zelle, E. De Hulster, W. A. Van Winden, P. De Waard, C. Dijkema, A. A. Winkler, J. M. A. Geertman, J. P. Van Dijken, J. T. Pronk and A. J. A. Van Maris, Appl. Environ. Microbiol., 2008, 74, 2766-2777. 147
- T. Çakir, K. R. Patil, Z. iIsen Onsan, K. O. Ulgen, B. Kirdar and J. Nielsen, Mol. Syst. Biol., 2006, 2, 50. 148
- A. P. Burgard, E. V Nikolaev, C. H. Schilling and C. D. Maranas, Genome Res., 2004, 14, 301-312. 149
- J. G. Bundy, B. Papp, R. Harmston, R. A. Browne, E. M. Clayson, N. Burton, R. J. Reece, S. G. Oliver and K. M. Brindle, Genome Res., 2007, 17, 510-519. 150
- C. E. Garcı ´a Sa ´nchez, C. A. Vargas Garcı ´a and R. G. Torres Sa ´ez, PLoS One, 2012, 7, e43006. 151
- R. Agren, J. M. Otero and J. Nielsen, J. Ind. Microbiol. Biotechnol., 2013, 40, 735-747. 152
- P. B. Hyland, S. L. S. Mun and R. Mahadevan, Ind. Biotechnol., 2013, 9, 229-235. 153
- U. Sauer, Mol. Syst. Biol., 2006, 2, 62. 154
- L. M. Blank, L. Kuepfer and U. Sauer, Genome Biol., 2005, 6, R49.
- A. Misra, M. F. Conway, J. Johnnie, T. M. Qureshi, B. Lige, A. M. Derrick, E. C. Agbo and G. Sriram, Front. Microbiol., 2013, 4, 1-15. 156
- E. S. Snitkin and D. Segre `, Int. Conf. Genome Inf., 2008, 20, 123-134.
- A. Dra ¨ger and B. Ø. Palsson, Front. Bioeng. Biotechnol., 2014, 2, 1-20.
- A. Kumar, P. F. Suthers and C. D. Maranas, BMC Bioinf., 2012, 13, 6. 159
- D. Weininger, J. Chem. Inf. Comput. Sci., 1988, 28, 31-36. 160
- C. Brooksbank, G. Cameron and J. Thornton, Nucleic Acids Res., 2005, 33, 46-53. 161
- S. J. Coles, N. E. Day, P. Murray-Rust, H. S. Rzepa and Y. Zhang, Org. Biomol. Chem., 2005, 3, 1832-1834.
- H. W. Mewes, A. Ruepp, F. Theis, T. Rattei, M. Walter, D. Frishman, K. Suhre, M. Spannagl, K. F. X. Mayer, V. Stu ¨mpflen and A. Antonov, Nucleic Acids Res., 2011, 39, 220-224.
- H. W. Wisselink, C. Cipollina, B. Oud, B. Crimi, J. J. Heijnen, J. T. Pronk and A. J. A. van Maris, Metab. Eng., 2010, 12, 537-551.
- Authors
- Sánchez, B. J., & Nielsen, J.
- Affiliations
- Novo Nordisk Foundation (DK)
- Venue
- Integrative Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015
- Volume
- 7
- Issue
- 8
- Pages
- 846-858
- ISSN
- 1757-9694 (ISSN-L)
- 1757-9708
- OpenAlex
- W2108977450
- Cited by
- 75
- References
- 163
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 7 · 2015: 3
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Integrative Biology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Chalmers Research (Chalmers University of Technology) (submittedVersion)
- Chalmers Publication Library (Chalmers University of Technology) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, cc-by)
- Funders
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Novo Nordisk Fonden (NNF10CC1016517)
- Comisión Nacional de Investigación Científica y Tecnológica
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- genome-scale metabolic models, Saccharomyces cerevisiae, model evaluation, multi-omics integration, gene expression, flux data, metabolic engineering, systems biology
- MeSH terms
- Computer Simulation, Models, Biological, Saccharomyces cerevisiae, Systems Integration, Gene Expression Profiling, Genomics, Saccharomyces cerevisiae Proteins, Metabolic Networks and Pathways, Metabolic Flux Analysis
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