Cited by 75Microbial Metabolic Engineering and BioproductionBioinformatics and Genomic NetworksGene Regulatory Network Analysis

Genome scale models of yeast: towards standardized evaluation and consistent omic integration

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Sánchez, Benjamín J., Nielsen, Jens·2015·Integrative Biology

Abstract

We review genome scale models of yeast, how are they typically evaluated, and how can they be integrated with omic data.

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  1. D. Botstein, S. A. Chervitz and J. M. Cherry, Science, 1997, 277, 1259-1260.
  2. E. J. Steen, R. Chan, N. Prasad, S. Myers, C. J. Petzold, A. Redding, M. Ouellet and J. D. Keasling, Microb. Cell Fact., 2008, 7, 36.
  3. J. Zaldivar, J. Nielsen and L. Olsson, Appl. Microbiol. Biotechnol., 2001, 56, 17-34.
  4. D. K. Ro, E. M. Paradise, M. Ouellet, K. J. Fisher, K. L. Newman, J. M. Ndungu, K. A. Ho, R. A. Eachus, T. S. Ham, J. Kirby, M. C. Y. Chang, S. T. Withers, Y. Shiba, R. Sarpong and J. D. Keasling, Nature, 2006, 440, 940-943.
  5. S. Yamano, T. Ishii, M. Nakagawa, H. Ikenaga and N. Misawa, Biosci., Biotechnol., Biochem., 1994, 58, 1112-1114.
  6. E. J. Kerkhoven, P. J. Lahtvee and J. Nielsen, FEMS Yeast Res., 2014, 15, 1-13.
  7. A. Bordbar, J. M. Monk, Z. A. King and B. Ø. Palsson, Nat. Rev. Genet., 2014, 15, 107-120.
  8. M. A. Oberhardt, B. Ø. Palsson and J. A. Papin, Mol. Syst. Biol., 2009, 5, 320.
  9. G. Liu, A. Marras and J. Nielsen, Quant. Biol., 2014, 2, 30-46.
  10. I. Nookaew, R. Olivares-Herna ´ndez, S. Bhumiratana and J. Nielsen, Methods Mol. Biol., 2011, 759, 445-463.
  11. T. O ¨sterlund, I. Nookaew and J. Nielsen, Biotechnol. Adv., 2012, 30, 979-988.
  12. C. Bro, B. Regenberg, J. Fo ¨rster and J. Nielsen, Metab. Eng., 2006, 8, 102-111.
  13. D. Byrne, A. Dumitriu and D. Segre `, BMC Syst. Biol., 2012, 6, 127.
  14. B. K. S. Chung, M. Lakshmanan, M. Klement, B. Mohanty and D. Y. Lee, Chem. Eng. Sci., 2013, 103, 100-108.
  15. C. Y. Ng, M.-Y. Jung, J. Lee and M.-K. Oh, Microb. Cell Fact., 2012, 11, 68.
  16. N. C. Duarte, M. J. Herrgård and B. Ø. Palsson, Genome Res., 2004, 14, 1298-1309.
  17. L. Kuepfer, U. Sauer and L. M. Blank, Genome Res., 2005, 15, 1421-1430.
  18. I. Nookaew, M. C. Jewett, A. Meechai, C. Thammarongtham, K. Laoteng, S. Cheevadhanarak, J. Nielsen and S. Bhumiratana, BMC Syst. Biol., 2008, 2, 71.
  19. M. L. Mo, B. Ø. Palsson and M. J. Herrgård, BMC Syst. Biol., 2009, 3, 37.
  20. M. J. Herrgård, N. Swainston, P. D. Dobson, W. B. Dunn, K. Y. Arga, M. Arvas, N. Blu ¨thgen, S. Borger, R. Costenoble, M. Heinemann, M. Hucka, N. Le Nove `re, P. Li, W. Liebermeister, M. L. Mo, A. P. Oliveira, D. Petranovic, S. Pettifer, E. Simeonidis, K. Smallbone, I. Spasic ´, D. Weichart, R. Brent, D. S. Broomhead, H. V Westerhoff, B. Kirdar, M. Penttila ¨, E. Klipp, B. Ø. Palsson, U. Sauer, S. G. Oliver, P. Mendes, J. Nielsen and D. B. Kell, Nat. Biotechnol., 2008, 26, 1155-1160.
  21. P. D. Dobson, K. Smallbone, D. Jameson, E. Simeonidis, K. Lanthaler, P. Pir, C. Lu, N. Swainston, W. B. Dunn, P. Fisher, D. Hull, M. Brown, O. Oshota, N. J. Stanford, D. B. Kell, R. D. King, S. G. Oliver, R. D. Stevens and P. Mendes, BMC Syst. Biol., 2010, 4, 145.
  22. B. D. Heavner, K. Smallbone, B. Barker, P. Mendes and L. P. Walker, BMC Syst. Biol., 2012, 6, 1.
  23. H. W. Aung, S. A. Henry and L. P. Walker, Ind. Biotechnol., 2013, 9, 215-228.
  24. A. R. Zomorrodi and C. D. Maranas, BMC Syst. Biol., 2010, 4, 178.
  25. T. O ¨sterlund, I. Nookaew, S. Bordel and J. Nielsen, BMC Syst. Biol., 2013, 7, 36.
  26. P. Ghaffari, A. Mardinoglu, A. Asplund, S. Shoaie, C. Kampf, M. Uhlen and J. Nielsen, Sci. Rep., 2015, 5, 8183.
  27. B. D. Heavner and N. D. Price, in preparation. 30 A. Wagner and D. A. Fell, Proc. Biol. Sci., 2001, 268, 1803-1810.
  28. G. Del Rio, D. Koschu ¨tzki and G. Coello, BMC Syst. Biol., 2009, 3, 102.
  29. T. Rubina, M. Mednis and E. Stalidzans, CINTI 2013 -14th IEEE Int. Symp. Comput. Intell. Informatics, Proc., 2013, 411-418.
  30. D. Vitkup, P. Kharchenko and A. Wagner, Genome Biol., 2006, 7, R39.
  31. Y. Assenov, F. Ramı ´rez, S. E. Schelhorn, T. Lengauer and M. Albrecht, Bioinformatics, 2008, 24, 282-284.
  32. C. H. Chin, S. H. Chen, H. H. Wu, C. W. Ho, M. T. Ko and C. Y. Lin, BMC Syst. Biol., 2014, 8, S11.
  33. M. Kanehisa, S. Goto, Y. Sato, M. Kawashima, M. Furumichi and M. Tanabe, Nucleic Acids Res., 2014, 42, 199-205.
  34. R. Caspi, T. Altman, R. Billington, K. Dreher, H. Foerster, C. A. Fulcher, T. A. Holland, I. M. Keseler, A. Kothari, A. Kubo, M. Krummenacker, M. Latendresse, L. A. Mueller, Q. Ong, S. Paley, P. Subhraveti, D. S. Weaver, D. Weerasinghe, P. Zhang and P. D. Karp, Nucleic Acids Res., 2014, 42, 459-471.
  35. R. Mahadevan and C. H. Schilling, Metab. Eng., 2003, 5, 264-276.
  36. J. D. Orth, I. Thiele and B. Ø. Palsson, Nat. Biotechnol., 2010, 28, 245-248.
  37. A. Varma and B. Ø. Palsson, Appl. Environ. Microbiol., 1994, 60, 3724-3731.
  38. J. Fo ¨rster, I. Famili, B. Ø. Palsson and J. Nielsen, OMICS, 2003, 7, 193-202.
  39. G. Basler, Methods Mol. Biol., 2015, 1279, 183-204.
  40. D. Segre `, D. Vitkup and G. M. Church, Proc. Natl. Acad. Sci.
  41. U. S. A., 2002, 99, 15112-15117.
  42. T. Shlomi, O. Berkman and E. Ruppin, Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 7695-7700.
  43. G. Giaever, A. M. Chu, L. Ni, C. Connelly, L. Riles, S. Ve ´ronneau, S. W. Dow, A. Lucau-Danila, K. Anderson, B. Andre ´, A. P. Arkin, A. Astromoff, M. El Bakkoury, R. Bangham, R. Benito, S. Brachat, S. Campanaro, M. Curtiss, K. Davis, A. M. Deutschbauer, K.-D. Entian, P. Flaherty, F. Foury, D. J. Garfinkel, M. Gerstein, D. Gotte, U. Gu ¨ldener, J. H. Hegemann, S. Hempel, Z. S. Herman, D. F. Jaramillo, D. E. Kelly, S. L. Kelly, P. Ko ¨tter, D. LaBonte, D. C. Lamb, N. Lan, H. Liang, H. Liao, L. Liu, C. Luo, M. Lussier, R. Mao, P. Menard, S. L. Ooi, J. L. Revuelta, C. J. Roberts, M. Rose, P. Ross-Macdonald, B. Scherens, G. Schimmack, B. Shafer, D. D. Shoemaker, S. Sookhai-Mahadeo, R. K. Storms, J. N. Strathern, G. Valle, M. Voet, G. Volckaert, C. Wang, T. R. Ward, J. Wilhelmy, E. A. Winzeler, Y. Yang, G. S. Yen, E. Youngman, K. Yu, H. Bussey, J. D. Boeke, M. Snyder, P. Philippsen, R. W. Davis and M. Johnston, Nature, 2002, 418, 387-391.
  44. L. M. Steinmetz, C. Scharfe, A. M. Deutschbauer, D. Mokranjac, Z. S. Herman, T. Jones, A. M. Chu, G. Giaever, H. Prokisch, P. J. Oefner and R. W. Davis, Nat. Genet., 2002, 31, 400-404.
  45. E. A. Winzeler, D. D. Shoemaker, A. Astromoff, H. Liang, K. Anderson, B. Andre, R. Bangham, R. Benito, J. D. Boeke, H. Bussey, A. M. Chu, C. Connelly, K. Davis, F. Dietrich, S. W. Dow, M. El Bakkoury, F. Foury, S. H. Friend, E. Gentalen, G. Giaever, J. H. Hegemann, T. Jones, M. Laub, H. Liao, N. Liebundguth, D. J. Lockhart, A. Lucau-Danila, M. Lussier, N. M'Rabet, P. Menard, M. Mittmann, C. Pai, C. Rebischung, J. L. Revuelta, L. Riles, C. J. Roberts, P. Ross-MacDonald, B. Scherens, M. Snyder, S. Sookhai-Mahadeo, R. K. Storms, S. Ve ´ronneau, M. Voet, G. Volckaert, T. R. Ward, R. Wysocki, G. S. Yen, K. Yu, K. Zimmermann, P. Philippsen, M. Johnston and R. W. Davis, Science, 1999, 285, 901-906.
  46. S. R. Engel, R. Balakrishnan, G. Binkley, K. R. Christie, M. C. Costanzo, S. S. Dwight, D. G. Fisk, J. E. Hirschman, B. C. Hitz, E. L. Hong, C. J. Krieger, M. S. Livstone, S. R. Miyasato, R. S. Nash, R. Oughtred, J. Park, M. S. Skrzypek, S. Weng, E. D. Wong, K. Dolinski, D. Botstein and J. M. Cherry, Nucleic Acids Res., 2009, 38, 1-4.
  47. J. M. Cherry, E. L. Hong, C. Amundsen, R. Balakrishnan, G. Binkley, E. T. Chan, K. R. Christie, M. C. Costanzo, S. S. Dwight, S. R. Engel, D. G. Fisk, J. E. Hirschman, B. C. Hitz, K. Karra, C. J. Krieger, S. R. Miyasato, R. S. Nash, J. Park, M. S. Skrzypek, M. Simison, S. Weng and E. D. Wong, Nucleic Acids Res., 2012, 40, 1-6.
  48. M. Costanzo, A. Baryshnikova, J. Bellay, Y. Kim, E. D. Spear, C. S. Sevier, H. Ding, J. L. Y. Koh, K. Toufighi, S. Mostafavi, J. Prinz, R. P. St Onge, B. VanderSluis, T. Makhnevych, F. J. Vizeacoumar, S. Alizadeh, S. Bahr, R. L. Brost, Y. Chen, M. Cokol, R. Deshpande, Z. Li, Z. Y. Lin, W. Liang, M. Marback, J. Paw, B. J. San Luis, E. Shuteriqi, A. H. Y. Tong, N. Van Dyk, I. M. Wallace, J. A. Whitney, M. T. Weirauch, G. Zhong, H. Zhu, W. A. Houry, M. Brudno, S. Ragibizadeh, B. Papp, C. Pa ´l, F. P. Roth, G. Giaever, C. Nislow, O. G. Troyanskaya, H. Bussey, G. D. Bader, A. C. Gingras, Q. D. Morris, P. M. Kim, C. A. Kaiser, C. L. Myers, B. J. Andrews and C. Boone, Science, 2010, 327, 425-431.
  49. E. S. Snitkin, A. M. Dudley, D. M. Janse, K. Wong, G. M. Church and D. Segre `, Genome Biol., 2008, 9, R140.
  50. B. Vandersluis, D. C. Hess, C. Pesyna, E. W. Krumholz, T. Syed, B. Szappanos, C. Nislow, B. Papp, O. G. Troyanskaya, C. L. Myers and A. A. Caudy, Genome Biol., 2014, 15, R64.
  51. D. McCloskey, B. Ø. Palsson and A. M. Feist, Mol. Syst. Biol., 2013, 9, 661.
  52. E. Gonçalves, J. Bucher, A. Ryll, J. Niklas, K. Mauch, S. Klamt, M. Rocha and J. Saez-Rodriguez, Mol. BioSyst., 2013, 9, 1576-1583.
  53. R. Saha, A. Chowdhury and C. D. Maranas, Curr. Opin. Biotechnol., 2014, 29, 39-45.
  54. A. S. Blazier and J. A. Papin, Front. Physiol., 2012, 3, 299.
  55. A. Hoppe, Metabolites, 2012, 2, 614-631.
  56. M. Åkesson, J. Fo ¨rster and J. Nielsen, Metab. Eng., 2004, 6, 285-293.
  57. J. L. Hjersted and M. A. Henson, IET Syst. Biol., 2009, 3, 167-179.
  58. B. J. Sa ´nchez, J. R. Pe ´rez-Correa and E. Agosin, Metab. Eng., 2014, 25, 159-173.
  59. S. A. Becker and B. Ø. Palsson, PLoS Comput. Biol., 2008, 4, e1000082.
  60. H. Zur, E. Ruppin and T. Shlomi, Bioinformatics, 2010, 26, 3140-3142.
  61. E. Almaas, B. Kova ´cs, T. Vicsek, Z. N. Oltvai and A.-L. Baraba ´si, Nature, 2004, 427, 839-843.
  62. Y. Bilu, T. Shlomi, N. Barkai and E. Ruppin, PLoS Comput. Biol., 2006, 2, 0932-0938.
  63. O. Rokhlenko, T. Shlomi, R. Sharan, E. Ruppin and R. Y. Pinter, Bioinformatics, 2007, 23, 2139-2146.
  64. S. Bordel, R. Agren and J. Nielsen, PLoS Comput. Biol., 2010, 6, 16.
  65. J. L. Martı ´nez, S. Bordel, K. K. Hong and J. Nielsen, FEMS Yeast Res., 2014, 14, 654-662.
  66. This journal is © The Royal Society of Chemistry 2015 Integr. Biol., 2015, 7, 846--858 | 857
  67. C. J. Kennedy, P. M. Boyle, Z. Waks and P. A. Silver, Genetics, 2009, 183, 385-397.
  68. P. A. Jensen and J. A. Papin, Bioinformatics, 2011, 27, 541-547.
  69. R. J. P. Van Berlo, D. de Ridder, J. M. Daran, P. A. S. Daran- Lapujade, B. Teusink and M. J. T. Reinders, IEEE/ACM Trans. Comput. Biol. Bioinf., 2011, 8, 206-216.
  70. A. Salehzadeh-Yazdi, Y. Asgari, A. A. Saboury and A. Masoudi- Nejad, PLoS One, 2014, 9, e111686.
  71. J. Kim and J. L. Reed, Genome Biol., 2012, 13, R78.
  72. D. Lee, K. Smallbone, W. B. Dunn, E. Murabito, C. L. Winder, D. B. Kell, P. Mendes and N. Swainston, BMC Syst. Biol., 2012, 6, 1.
  73. S. Rossell, M. A. Huynen and R. A. Notebaart, PLoS Comput. Biol., 2013, 9, e1002988.
  74. H. S. Song, J. Reifman and A. Wallqvist, PLoS One, 2014, 9, e112524.
  75. M. J. Herrgård, B. S. Lee, V. Portnoy and B. Ø. Palsson, Genome Res., 2006, 16, 627-635.
  76. P. A. Jensen, K. A. Lutz and J. A. Papin, BMC Syst. Biol., 2011, 5, 147.
  77. S. Chandrasekaran and N. D. Price, PLoS Comput. Biol., 2013, 9, e1003370.
  78. J. M. Savinell and B. Ø. Palsson, J. Theor. Biol., 1992, 154, 421-454.
  79. E. Reznik, P. Mehta and D. Segre `, PLoS Comput. Biol., 2013, 9, e1003195.
  80. A. Wagner, R. Zarecki, L. Reshef, C. Gochev, R. Sorek, U. Gophna and E. Ruppin, Proc. Natl. Acad. Sci. U. S. A., 2013, 110, 19166-19171.
  81. K. Yizhak, O. Gabay, H. Cohen and E. Ruppin, Nat. Com- mun., 2013, 4, 2632.
  82. B. Barker, N. Sadagopan, Y. Wang, K. Smallbone, M. R. Christopher, H. Xi, J. W. Locasale and Z. Gu, Mol. Networks, 2014, arXiv:1404.4755. · arXiv
  83. D. Machado and M. J. Herrgård, PLoS Comput. Biol., 2014, 10, e1003580.
  84. K. R. Patil and J. Nielsen, Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 2685-2689.
  85. A. P. Oliveira, K. R. Patil and J. Nielsen, BMC Syst. Biol., 2008, 2, 17.
  86. R. Usaite, K. R. Patil, T. Grotkjær, J. Nielsen and B. Regenberg, Appl. Environ. Microbiol., 2006, 72, 6194-6203.
  87. S. L. Westergaard, A. P. Oliveira, C. Bro, L. Olsson and J. Nielsen, Biotechnol. Bioeng., 2007, 96, 134-145.
  88. D. Cimini, K. R. Patil, C. Schiraldi and J. Nielsen, BMC Syst. Biol., 2009, 3, 17.
  89. R. Usaite, M. C. Jewett, A. P. Oliveira, J. R. Yates, L. Olsson and J. Nielsen, Mol. Syst. Biol., 2009, 5, 319.
  90. P. Chumnanpuen, J. Zhang, I. Nookaew and J. Nielsen, Mol. Genet. Genomics, 2012, 287, 541-554.
  91. P. Chumnanpuen, I. Nookaew and J. Nielsen, BMC Syst. Biol., 2013, 7, S7.
  92. W. A. Bryant, M. J. E. Sternberg and J. W. Pinney, BMC Syst. Biol., 2013, 7, 26.
  93. M. C. Jewett, C. T. Workman, I. Nookaew, F. A. Pizarro, E. Agosin, L. I. Hellgren and J. Nielsen, G3, 2013, 3, 1979-1995.
  94. E. Lindfors, P. Jouhten, M. Oja, E. Rintala, M. Ores ˇic ˇand M. Penttila ¨, BMC Syst. Biol., 2014, 8, 16.
  95. P. Kharchenko, D. Vitkup and G. M. Church, Bioinfor- matics, 2004, 20, 178-185.
  96. P. Kharchenko, L. Chen, Y. Freund, D. Vitkup and G. M. Church, BMC Bioinf., 2006, 7, 177.
  97. K. Y. Teh and A. E. Lutz, J. Biotechnol., 2010, 147, 80-87.
  98. D. Segre `, A. Deluna, G. M. Church and R. Kishony, Nat. Genet., 2005, 37, 77-83. 100
  99. X. He, W. Qian, Z. Wang, Y. Li and J. Zhang, Nat. Genet., 2010, 42, 272-276. 101
  100. E. S. Snitkin and D. Segre `, PLoS Genet., 2011, 7, e1001294. 102
  101. R. Harrison, B. Papp, C. Pa ´l, S. G. Oliver and D. Delneri, Proc. Natl. Acad. Sci. U. S. A., 2007, 104, 2307-2312. 103
  102. B. Szappanos, K. Kova ´cs, B. Szamecz, F. Honti, M. Costanzo, A. Baryshnikova, G. Gelius-Dietrich, M. J. Lercher, M. Jelasity, C. L. Myers, B. J. Andrews, C. Boone, S. G. Oliver, C. Pa ´l and B. Papp, Nat. Genet., 2011, 43, 656-662. 104
  103. L. Xu, B. Barker and Z. Gu, Proc. Natl. Acad. Sci. U. S. A., 2012, 109, 10420-10425.
  104. A. R. Brochado, S. Andrejev, C. D. Maranas and K. R. Patil, PLoS Comput. Biol., 2012, 8, e1002758. 106
  105. R. Costenoble, P. Picotti, L. Reiter, R. Stallmach, M. Heinemann, U. Sauer and R. Aebersold, Mol. Syst. Biol., 2011, 7, 464. 107
  106. A. Ku ¨mmel, S. Panke and M. Heinemann, Mol. Syst. Biol., 2006, 2, 2006.0034. 109
  107. N. Zamboni, A. Ku ¨mmel and M. Heinemann, BMC Bioinf., 2008, 9, 199. 110
  108. J. C. Ewald, T. Matt and N. Zamboni, Mol. BioSyst., 2013, 9, 440-446.
  109. S. J. Jol, A. Ku ¨mmel, M. Terzer, J. Stelling and M. Heinemann, PLoS Comput. Biol., 2012, 8, 1-9.
  110. V. S. Martı ´nez, L. E. Quek and L. K. Nielsen, Biophys. J., 2014, 107, 493-503. 113
  111. K. Smallbone and P. Mendes, Ind. Biotechnol., 2013, 9, 179-184.
  112. N. J. Stanford, T. Lubitz, K. Smallbone, E. Klipp, P. Mendes and W. Liebermeister, PLoS One, 2013, 8, e79195. 115
  113. K. C. Soh, L. Miskovic and V. Hatzimanikatis, FEMS Yeast Res., 2012, 12, 129-143. 116
  114. C. M. Paget, J. M. Schwartz and D. Delneri, Mol. Ecol., 2014, 23, 5241-5257. 117
  115. J. L. Hjersted, M. A. Henson and R. Mahadevan, Biotechnol. Bioeng., 2007, 97, 1190-1204. 118
  116. R. Eslamloueyan and P. Setoodeh, Chem. Eng. Commun., 2011, 198, 1309-1338.
  117. A. Ghosh, H. Zhao and N. D. Price, PLoS One, 2011, 6, e27316. 120
  118. J. Zanghellini, K. Natter, C. Jungreuthmayer, A. Thalhammer, C. F. Kurat, G. Gogg-Fassolter, S. D. Kohlwein and H. H. Von Gru ¨nberg, FEBS J., 2008, 275, 5552-5563. 121
  119. T. J. Hanly and M. A. Henson, Biotechnol. Bioeng., 2011, 108, 376-385. 122
  120. J. T. Leppa ¨vuori, M. M. Domach and L. T. Biegler, Ind. Eng. Chem. Res., 2011, 50, 12080-12091.
  121. F. A. Vargas, F. A. Pizarro, J. R. Pe ´rez-Correa and E. Agosin, BMC Syst. Biol., 2011, 5, 75. 124
  122. T. J. Hanly, M. Urello and M. A. Henson, Appl. Microbiol. Biotechnol., 2012, 93, 2529-2541. 125
  123. P. Jouhten, M. Wiebe and M. Penttila ¨, FEBS J., 2012, 279, 3338-3354. 126
  124. T. J. Hanly and M. A. Henson, Biotechnol. Biofuels, 2013, 6, 44. 127
  125. K. Ho ¨ffner, S. M. Harwood and P. I. Barton, Biotechnol. Bioeng., 2013, 110, 792-802. 128
  126. J. A. Gomez, K. Ho ¨ffner and P. I. Barton, BMC Bioinf., 2014, 15, 409. 129
  127. T. J. Hanly and M. A. Henson, Biotechnol. Bioeng., 2014, 111, 272-284. 130
  128. P. K. Lisha and D. Sarkar, Bioprocess Biosyst. Eng., 2014, 37, 617-627. 131
  129. P. K. Lisha and D. Sarkar, Biotechnol. Res. Int., 2015, 2015, 238082.
  130. A. M. Willemsen, D. M. Hendrickx, H. C. J. Hoefsloot, M. M. W. B. Hendriks, S. A. Wahl, B. Teusink, A. K. Smilde and A. H. C. Van Kampen, Mol. BioSyst., 2015, 11, 137-145.
  131. A. Chowdhury, A. R. Zomorrodi and C. D. Maranas, PLoS Comput. Biol., 2014, 10, e1003487. 134
  132. K. Smallbone, E. Simeonidis, N. Swainston and P. Mendes, BMC Syst. Biol., 2010, 4, 6. 135
  133. A. F. Villaverde, D. Henriques, K. Smallbone, S. Bongard, J. Schmid, D. Cicin-Sain, A. Crombach, J. Saez-Rodriguez, K. Mauch, E. Balsa-Canto, P. Mendes, J. Jaeger and J. R. Banga, BMC Syst. Biol., 2015, 9, 8. 136
  134. R. Mahadevan, J. S. Edwards and F. J. Doyle III, Biophys. J., 2002, 83, 1331-1340. 137
  135. B. Teusink, J. Passarge, C. A. Reijenga, E. Esgalhado, C. C. Van Der Weijden, M. Schepper, M. C. Walsh, B. M. Bakker, K. Van Dam, H. V Westerhoff and J. L. Snoep, Eur. J. Biochem., 2000, 267, 5313-5329. 138 E. Klipp, Yeast, 2007, 24, 943-959. 139
  136. C. Reder, J. Theor. Biol., 1988, 135, 175-201. 140
  137. L. Miskovic and V. Hatzimanikatis, Trends Biotechnol., 2010, 28, 391-397.
  138. Q. K. Beg, A. Vazquez, J. Ernst, M. A. de Menezes, Z. Bar- Joseph, A. L. Baraba ´si and Z. N. Oltvai, Proc. Natl. Acad. Sci.
  139. U. S. A., 2007, 104, 12663-12668.
  140. M. J. Van Hoek and R. M. Merks, BMC Syst. Biol., 2012, 6, 22. 143
  141. M. Celton, A. Goelzer, C. Camarasa, V. Fromion and S. Dequin, Metab. Eng., 2012, 14, 366-379. 144
  142. D. Dikicioglu, S. Oc, B. M. Rash, W. B. Dunn, P. Pir, D. B. Kell, B. Kirdar and S. G. Oliver, Mol. BioSyst., 2014, 10, 93-102. 145
  143. B. J. Stewart, A. Navid, K. W. Turteltaub and G. Bench, Anal. Chem., 2010, 82, 9812-9817.
  144. R. M. Zelle, E. De Hulster, W. A. Van Winden, P. De Waard, C. Dijkema, A. A. Winkler, J. M. A. Geertman, J. P. Van Dijken, J. T. Pronk and A. J. A. Van Maris, Appl. Environ. Microbiol., 2008, 74, 2766-2777. 147
  145. T. Çakir, K. R. Patil, Z. iIsen Onsan, K. O. Ulgen, B. Kirdar and J. Nielsen, Mol. Syst. Biol., 2006, 2, 50. 148
  146. A. P. Burgard, E. V Nikolaev, C. H. Schilling and C. D. Maranas, Genome Res., 2004, 14, 301-312. 149
  147. J. G. Bundy, B. Papp, R. Harmston, R. A. Browne, E. M. Clayson, N. Burton, R. J. Reece, S. G. Oliver and K. M. Brindle, Genome Res., 2007, 17, 510-519. 150
  148. C. E. Garcı ´a Sa ´nchez, C. A. Vargas Garcı ´a and R. G. Torres Sa ´ez, PLoS One, 2012, 7, e43006. 151
  149. R. Agren, J. M. Otero and J. Nielsen, J. Ind. Microbiol. Biotechnol., 2013, 40, 735-747. 152
  150. P. B. Hyland, S. L. S. Mun and R. Mahadevan, Ind. Biotechnol., 2013, 9, 229-235. 153
  151. U. Sauer, Mol. Syst. Biol., 2006, 2, 62. 154
  152. L. M. Blank, L. Kuepfer and U. Sauer, Genome Biol., 2005, 6, R49.
  153. A. Misra, M. F. Conway, J. Johnnie, T. M. Qureshi, B. Lige, A. M. Derrick, E. C. Agbo and G. Sriram, Front. Microbiol., 2013, 4, 1-15. 156
  154. E. S. Snitkin and D. Segre `, Int. Conf. Genome Inf., 2008, 20, 123-134.
  155. A. Dra ¨ger and B. Ø. Palsson, Front. Bioeng. Biotechnol., 2014, 2, 1-20.
  156. A. Kumar, P. F. Suthers and C. D. Maranas, BMC Bioinf., 2012, 13, 6. 159
  157. D. Weininger, J. Chem. Inf. Comput. Sci., 1988, 28, 31-36. 160
  158. C. Brooksbank, G. Cameron and J. Thornton, Nucleic Acids Res., 2005, 33, 46-53. 161
  159. S. J. Coles, N. E. Day, P. Murray-Rust, H. S. Rzepa and Y. Zhang, Org. Biomol. Chem., 2005, 3, 1832-1834.
  160. H. W. Mewes, A. Ruepp, F. Theis, T. Rattei, M. Walter, D. Frishman, K. Suhre, M. Spannagl, K. F. X. Mayer, V. Stu ¨mpflen and A. Antonov, Nucleic Acids Res., 2011, 39, 220-224.
  161. H. W. Wisselink, C. Cipollina, B. Oud, B. Crimi, J. J. Heijnen, J. T. Pronk and A. J. A. van Maris, Metab. Eng., 2010, 12, 537-551.

Authors
Sánchez, B. J., & Nielsen, J.
Affiliations
Novo Nordisk Foundation (DK)
Venue
Integrative Biology
Published
2015
Volume
7
Issue
8
Pages
846-858
ISSN
  • 1757-9694 (ISSN-L)
  • 1757-9708
OpenAlex
W2108977450
Cited by
75
References
163
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 7 · 2015: 3
FWCI
1.16
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Integrative Biology (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • Chalmers Research (Chalmers University of Technology) (submittedVersion)
  • Chalmers Publication Library (Chalmers University of Technology) (submittedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, cc-by)
Funders
  • Knut och Alice Wallenbergs Stiftelse
  • Novo Nordisk
  • Novo Nordisk Fonden (NNF10CC1016517)
  • Comisión Nacional de Investigación Científica y Tecnológica
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords
genome-scale metabolic models, Saccharomyces cerevisiae, model evaluation, multi-omics integration, gene expression, flux data, metabolic engineering, systems biology
MeSH terms
Computer Simulation, Models, Biological, Saccharomyces cerevisiae, Systems Integration, Gene Expression Profiling, Genomics, Saccharomyces cerevisiae Proteins, Metabolic Networks and Pathways, Metabolic Flux Analysis

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