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Cited by 31Cell Adhesion Molecules ResearchCellular Mechanics and InteractionsProtein Structure and Dynamics

Mechanisms of integrin and filamin binding and their interplay with talin during early focal adhesion formation

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Truong, Tiffany, Shams, Hengameh, Mofrad, Mohammad R. K.·2015·Integrative Biology
DOI 10.1039/c5ib00133a
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Abstract

Mechanisms of the interplay among filamin, integrin and talin during early focal adhesion formation were explored using molecular dynamics simulations.

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  • Filamin A controls the avidity and affinity of β1-containing integrins by enhancing their trafficking and presentation at the cell surface and their clustering.

    “Filamin A is a critical factor controlling the avidity and affinity of β1 containing integrins, as it enhances their trafficking and presentation at the cell surface as well as their clustering (Truong et al. 2015).”

    From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Truong et al. 2015

    The Introduction (page unavailable) says filamin helps recycle integrins to the cell membrane, increasing surface expression, and that its binding sites facilitate integrin clustering. It also says filamin binds β1 integrins, but does not establish that filamin A controls the avidity or affinity of β1-containing integrins through those mechanisms. The paper’s simulations instead examine αIIbβ3 integrin. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Truong, T., Shams, H., & Mofrad, M. R. K.
Affiliations
University of California, Berkeley (US)
Corresponding author
Mofrad, Mohammad R. K.
ORCID
Venue
Integrative Biology
Publisher
Oxford University Press (OUP)
Published
2015
Volume
7
Issue
10
Pages
1285-1296
ISSN
  • 1757-9694 (ISSN-L)
  • 1757-9708
DOI
10.1039/c5ib00133a
OpenAlex
W1926926867
Cited by
31
References
0
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 2
FWCI
3.53
Type
journal article
Language
en
Open access
Locations
  • Integrative Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Directorate for Biological Sciences (CAREER Award CBET-0955291)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords
filamin A, integrins, integrin αIIbβ3, talin, focal adhesion formation, actin cross-linking, electrostatic interactions, hydrophobic interactions, integrin cytoplasmic tail, cell adhesion, molecular dynamics simulation
MeSH terms
Amino Acid Sequence, Binding Sites, Binding, Competitive, Biomechanical Phenomena, Humans, Models, Molecular, Protein Binding, Protein Conformation, Talin, Focal Adhesions, Integrin beta3, Protein Interaction Domains and Motifs, Static Electricity, Molecular Dynamics Simulation, Filamins

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