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The pH-responsive behaviour of poly(acrylic acid) in aqueous solution is dependent on molar mass
Open accessAbstract
Fluorescence spectroscopy on a series of aqueous solutions of poly(acrylic acid) containing a luminescent label showed that polymers with molar mass, Mn < 16.5 kDa did not exhibit a pH responsive conformational change, which is typical of higher molar mass poly(acrylic acid). Below this molar mass, polymers remained in an extended conformation, regardless of pH. Above this molar mass, a pH-dependent conformational change was observed. Diffusion-ordered nuclear magnetic resonance spectroscopy confirmed that low molar mass polymers did not undergo a conformational transition, although large molar mass polymers did exhibit pH-dependent diffusion.
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“Polyacrylic acid (PAA), which is an anionic synthetic compound, can form pH-responsive hydrogel, swells/dissolves at pH higher than its pKa, and remains collapsed at acidic pH (pH < pKa) [123].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [123]
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Metadata
- Authors
- Swift, T., Swanson, L., Geoghegan, M., & Rimmer, S.
- Affiliations
- University of Bradford (GB)
- University of Sheffield (GB)
- Corresponding author
- Geoghegan, Mark
- Rimmer, Stephen
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 12
- Issue
- 9
- Pages
- 2542-2549
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2288268375
- Cited by
- 455
- References
- 48
- Citations by year
- 2026: 43 · 2025: 48 · 2024: 52 · 2023: 49 · 2022: 46 · 2021: 57 · 2020: 47 · 2019: 46 · 2018: 30 · 2017: 31 · 2016: 6
- FWCI
- 25.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Soft Matter (publishedVersion, cc-by)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Bradford Scholars (University of Bradford) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Engineering and Physical Sciences Research Council
- Topics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- poly(acrylic acid), pH-responsive polymers, molar mass dependence, conformational change, chain conformation, polymer diffusion, aqueous polymer solutions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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