Biodegradable citrate-based polyesters with S-nitrosothiol functional groups for nitric oxide release
Abstract
Herein, we report the synthesis and characterization of biodegradable citrate-based polyesters that were functionalized for nitric oxide release. The material extracts did not exhibit cytotoxicity as evaluated with human dermal fibroblasts.
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Biodegradable polymers such as citrate-based or saccharide-based polymers (dextran, chitosan) are attractive scaffolds for NO delivery because of natural occurrence, biodegradability, tolerability to mammalian cells, and accessibility for NO donor functionalization.
“Lastly, several biodegradable polymers, such as citrate-based225 or saccharide-based polymers (e.g., dextran227,244 and chitosan86,87,220) provide very attractive scaffolds for NO delivery because of their natural occurrence, biodegradability, tolerability to mammalian cells and accessibility for NO donor functionalization reactions.220,244,245”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [225]
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References 59 · Cited by 18
- Authors
- Yapor, J. P., Lutzke, A., Pegalajar-Jurado, A., Neufeld, B. H., Damodaran, V. B., & Reynolds, M. M.
- Affiliations
- Colorado State University (US)
- Department of Chemistry
- Corresponding author
- Reynolds, M. M.
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 3
- Issue
- 48
- Pages
- 9233-9241
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2177930152
- Cited by
- 18
- References
- 59
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 5
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Congressionally Directed Medical Research Programs (W81XWH-11-2-0113)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- biodegradable polyesters, nitric oxide release, cysteamine, controlled release, human dermal fibroblasts, cytotoxicity, biomedical polymers
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