Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles
Open accessAbstract
Co-delivery of the cell differentiation agent ATRA significantly enhances the anti-metastasis effect of nanoparticle albumin-bound paclitaxel in breast cancer treatment.
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Formulations with high (above 100 μg/mg), medium (between 100 and 25 μg/mg), and low (below 25 μg/mg) RA loading have been described.
“Formulations with high (above 100 μg/mg of formulation)51,56,60, medium (between 100 and 25 μg/mg of formulation)44,45, and low (below 25 μg/mg of formulation)7,58 loading have been described.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [56]
Several RA-polymer conjugates have been developed to release RA by hydrolytic cleavage of ester bonds, by enzymatic cleavage of amide bonds by proteases present in the targeted tissue, or by reducing environments such as the cell cytoplasm.
“For example, several RA-polymer conjugates have been developed to release RA by hydrolytic cleavage of ester bonds50,52, by enzymatic cleavage of amide bonds by proteases present in the targeted tissue28,65–67 or by reducing environments56 such as the cell cytoplasm.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [56]
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References 30 · Cited by 34
- Authors
- Huang, H., Shi, H., Liu, J., Min, Y., Wang, Y., Wang, A. Z., Wang, J., & Liu, Y.
- Affiliations
- University of Science and Technology of China (CN)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Liu, Yangzhong
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 53
- Issue
- 1
- Pages
- 212-215
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2559792556
- Cited by
- 34
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 2
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-08-22)
- Open access
- green
- doi.org
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Keywords
- all-trans retinoic acid, paclitaxel, co-delivery, breast cancer, metastasis, human serum albumin, drug combination therapy, nanomedicine
- MeSH terms
- Albumin-Bound Paclitaxel, Animals, Antineoplastic Agents, Breast Neoplasms, Drug Carriers, Humans, Models, Molecular, Neoplasm Metastasis, Protein Conformation, Tretinoin, Cell Line, Tumor, Mice, Nanoparticles
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