Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

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1. Small molecule fluorescent probes for the detection of reactive nitrogen species in biological systems
   Yongqing Zhou, Xiaofeng Yang, Jing Zhang, Shuai Xu, Juan Li, Wenshou Wang, Mei Yan · 2023 · Coordination Chemistry Reviews
2. Oxyhaemoglobin saturation NIR-IIb imaging for assessing cancer metabolism and predicting the response to immunotherapy
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3. High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model
   Dan Cheng, Xiangyang Gong, Qian Wu, Jie Yuan, Yun Lv, Lin Yuan, Xiaobing Zhang · 2020 · Analytical Chemistry
4. Resorufin-based responsive probes for fluorescence and colorimetric analysis
   Lu Tian, Huan Feng, Zhichao Dai, Run Zhang · 2020 · Journal of Materials Chemistry B
5. Dual-Locked Near-Infrared Fluorescent Probes for Precise Detection of Melanoma via Hydrogen Peroxide–Tyrosinase Cascade Activation
   Haiyue Peng, Ting Wang, Guorui Li, Jing Huang, Quan Yuan · 2021 · Analytical Chemistry
6. FRET-based ratiometric fluorescent detection of arginine in mitochondrion with a hybrid nanoprobe
   Yueyue Li, Yanan Ban, Ruihui Wang, Zheng Wang, Zhanxian Li, Chen‐Jie Fang, Mingming Yu · 2019 · Chinese Chemical Letters
7. Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury
   Yong Zhang, Xueqian Chen, Qing Yuan, Yongning Bian, Mingrui Li, Yaling Wang, Xueyun Gao, Dongdong Su · 2021 · Chemical Science
8. Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress
   Xiaoyan Zeng, Yurou Huang, Jing Dong, Xiaoxie Ma, Jia-Xu Nan, Weijie Chen, Hong‐Yan Lin, Wen‐Chao Yang, Xiaogang Liu, Jun Yin et al. · 2022 · Advanced Agrochem
9. Substrate-Photocaged Enzymatic Fluorogenic Probe Enabling Sequential Activation for Light-Controllable Monitoring of Intracellular Tyrosinase Activity
   Sheng Yang, Jia‐Xing Jiang, Anxin Zhou, Yibo Zhou, Wenling Ye, Dongsheng Cao, Ronghua Yang · 2020 · Analytical Chemistry
10. Visualization of biothiols and HClO in cancer therapy via a multi-responsive fluorescent probe
    Xiaopeng Yang, Jianfei Liu, Peiyao Xie, Xiaojing Han, Di Zhang, Yong Ye, Yufen Zhao · 2021 · Sensors and Actuators B Chemical
11. Recent advances in molecular fluorescent probes for organic phosphate biomolecules recognition
    Wei Li, Xiangyang Gong, Xiaopeng Fan, Shulu Yin, Dongdong Su, Xiaobing Zhang, Lin Yuan · 2019 · Chinese Chemical Letters
12. ICG‐Conjugated and 125I‐Labeled Polymeric Micelles with High Biosafety for Multimodality Imaging‐Guided Photothermal Therapy of Tumors
    Lijun Yang, Congrou Zhang, Jinjian Liu, Fan Huang, Yumin Zhang, Xing‐Jie Liang, Jianfeng Liu · 2020 · Advanced Healthcare Materials
13. Molecular probes for human cytochrome P450 enzymes: Recent progress and future perspectives
    Jingjing Wu, Xiao‐Qing Guan, Ziru Dai, Rong-Jing He, Xinxin Ding, Ling Yang, Guang‐Bo Ge · 2020 · Coordination Chemistry Reviews
14. Fluorescent probes for the detection of alkaline phosphatase in biological systems: Recent advances and future prospects
    Kai Wang, Wei Wang, Xiangyang Zhang, Ai-Qin Jiang, Yu‐Shun Yang, Hai‐Liang Zhu · 2021 · TrAC Trends in Analytical Chemistry
15. A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging
    Jingming Zhang, Anastasia Rakhimbekova, Xiaojiang Duan, Qingqing Yin, Catherine A. Foss, Yan Fan, Yangyang Xu, Xuesong Li, Xuekang Cai, Zsófia Kutil et al. · 2021 · Nature Communications
16. Molecule fluorescent probes for adenosine triphosphate imaging in cancer cells and in vivo
    Binghuan Huang, Bing Liang, Renshuai Zhang, Dongming Xing · 2021 · Coordination Chemistry Reviews
17. Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery
    Haidong Li, Dayeh Kim, Qichao Yao, Haoying Ge, Jeewon Chung, Jiangli Fan, Jingyun Wang, Xiaojun Peng, Juyoung Yoon · 2020 · Angewandte Chemie
18. Dual-locking fluorescent nanoprobes for HAase-triggered carbon monoxide imaging in living cells
    Yong Tian, Zhenhua Zhou, Jiankang Gong, Jingwen Li, Chun He, Jian Chen, Shu Chen, Rongjin Zeng, Zhiqiang Mao, Peisheng Zhang · 2023 · Sensors and Actuators B Chemical
19. Efficient cell surface labelling of live zebrafish embryos: wash-free fluorescence imaging for cellular dynamics tracking and nanotoxicity evaluation
    Hao‐Ran Jia, Ya‐Xuan Zhu, Ke‐Fei Xu, Guang‐Yu Pan, Xiaoyang Liu, Ying Qiao, Fu‐Gen Wu · 2019 · Chemical Science
20. Spectro-electrochemical assessments of DNA/BSA interactions, cytotoxicity, radical scavenging and pharmacological implications of biosensitive and biologically active morpholine-based metal( ii ) complexes: a combined experimental and computational investigation
    Karunganathan Sakthikumar, Rajadurai Vijay Solomon, Jeyaraj Dhaveethu Raja · 2019 · RSC Advances
21. Nucleic acid-based molecular computation heads towards cellular applications
    Lanlan Chen, Wanzhen Chen, Guo Liu, Jingying Li, Chunhua Lü, Juan Li, Weihong Tan, Huanghao Yang · 2021 · Chemical Society Reviews
22. Synthesis and Anticancer Evaluation of 1,4‐Naphthoquinone Derivatives Containing a Phenylaminosulfanyl Moiety
    Palanisamy Ravichandiran, Sivakumar Allur Subramaniyan, Seon‐Young Kim, Jong‐Soo Kim, Byung‐Hyun Park, Kwan Seob Shim, Dong Jin Yoo · 2019 · ChemMedChem
23. Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication
    Ao Jiang, Guang Chen, Jie Xu, Yuxia Liu, Guanghui Zhao, Zhenjun Liu, Tao Chen, Yulin Li, Tony D. James · 2019 · Chemical Communications
24. A Bifunctional Fluorescent Probe for Imaging Lipid Droplets Polarity/So2 During Ferroptosis
    Peiyao Xie, Jianfei Liu, Xiaopeng Yang, Weimin Zhu, Yong Ye · 2022 · Sensors and Actuators B Chemical
25. Enzymatic Noncovalent Synthesis of Supramolecular Soft Matter for Biomedical Applications
    Adrianna N. Shy, Beom Jin Kim, Bing Xu · 2019 · Matter
26. In Vivo Visualization of γ-Glutamyl Transpeptidase Activity with an Activatable Self-Immobilizing Near-Infrared Probe
    Yuyao Li, Chenghong Xue, Zhijun Fang, Weipan Xu, Hexin Xie · 2020 · Analytical Chemistry
27. Evolving a Unique Red-Emitting Fluorophore with an Optically Tunable Hydroxy Group for Imaging Nitroreductase in Cells, in Tissues, and in Vivo
    Rong Peng, Jie Yuan, Dan Cheng, Tian‐Bing Ren, Fangping Jin, Ronghua Yang, Lin Yuan, Xiaobing Zhang · 2019 · Analytical Chemistry
28. A Space‐Dependent ‘Enzyme‐Substrate’ Type Probe based on ‘Carboxylesterase‐Amide Group’ for Ultrafast Fluorescent Imaging Orthotopic Hepatocellular Carcinoma
    Ying Wen, Ning Jing, Min Zhang, Fangjun Huo, Zhuoyu Li, Caixia Yin · 2023 · Advanced Science
29. Molecular imaging: design mechanism and bioapplications
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30. A mitochondria-targetable two-photon fluorescent probe with a far-red to near-infrared emission for sensing hypochlorite in biosystems
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31. Theranostic applications of biomolecule‐responsive aggregation‐induced emission luminogens
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32. Recent advances in enzyme-activated NIR fluorescent probes for biological applications
    Hyunsun Jeong, Xiaofeng Wu, Jun‐Seok Lee, Juyoung Yoon · 2023 · TrAC Trends in Analytical Chemistry
33. Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies
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34. Multifunctional Fluorescent Probe for Simultaneously Detecting Microviscosity, Micropolarity, and Carboxylesterases and Its Application in Bioimaging
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35. An NIR Fluorescence Turn‐on and MRl Bimodal Probe for Concurrent Real‐time in vivo Sensing and Labeling of β ‐Galactosidase
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36. Superoxide Anion-Mediated Afterglow Mechanism-Based Water-Soluble Zwitterion Dye Achieving Renal-Failure Mice Detection
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37. Controlled In Situ Self-Assembly of Biotinylated Trans-Cyclooctene Nanoparticles for Orthogonal Dual-Pretargeted Near-Infrared Fluorescence and Magnetic Resonance Imaging
    Jianhui Weng, Zheng Huang, Yili Liu, Xidan Wen, Yinxing Miao, Jing‐Juan Xu, Deju Ye · 2024 · Journal of the American Chemical Society
38. Rational Design of a Long-Wavelength Fluorescent Probe for Highly Selective Sensing of Carboxylesterase 1 in Living Systems
    Zhenhao Tian, Lele Ding, Kun Li, Yun‐Qing Song, Tongyi Dou, Jie Hou, Xiangge Tian, Lei Feng, Guang‐Bo Ge, Jingnan Cui · 2019 · Analytical Chemistry
39. Visualizing Oxidative Stress Level for Timely Assessment of Ischemic Stroke via a Ratiometric Near-Infrared-II Luminescent Nanoprobe
    Meng Zhang, Zijun Wang, Caixia Wang, Yuting Wu, Zhen Li, Zhihong Liu · 2021 · ACS Nano
40. A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation
    Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu · 2022 · ACS Central Science
41. A colorimetric and fluorescent lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food
    Juanjuan Wu, Lirong Jiang, Peter Verwilst, Jusung An, Hongyan Zeng, Lintao Zeng, Guangle Niu, Jong Seung Kim · 2019 · Chemical Communications
42. Recent progress of fluorescent probes for the detection of alkaline phosphatase (ALP): A review
    Hongyi Zhang, Qikai Ju, Shude Pang, Ningning Wei, Yanru Zhang · 2021 · Dyes and Pigments
43. Recent progress of crystalline porous organic frameworks as ratiometric fluorescence biosensing platforms
    Tianqun Song, Zongyang Liu, Qinbai Yun, Xiaotao Zhang, Kuo Yuan, Wenping Hu · 2023 · TrAC Trends in Analytical Chemistry
44. Visualization of Dynamic Changes in Labile Iron(II) Pools in Endoplasmic Reticulum Stress-Mediated Drug-Induced Liver Injury
    Lijie Wu, Qi Ding, Xin Wang, Ping Li, Nannan Fan, Yongqing Zhou, Lili Tong, Wen Zhang, Wei Zhang, Bo Tang · 2019 · Analytical Chemistry
45. Detection of iron (III) by chemo and fluoro-sensing technology
    Shampa Chakraborty, Moumi Mandal, Sadhana Suresh Rayalu · 2020 · Inorganic Chemistry Communications
46. Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics
    Jun Li, Yi Zhang, Pengzhan Wang, Le Yu, Jusung An, Ganzhen Deng, Yao Sun, Jong Seung Kim · 2020 · Coordination Chemistry Reviews
47. Recent Advances in Small Molecule‐Based Intracellular pH Probes
    Pankaj E. Hande, Yogesh G. Shelke, Anindya Datta, Santosh J. Gharpure · 2021 · ChemBioChem
48. Aggregation-Induced Emission (AIE) in Super-resolution Imaging: Cationic AIE Luminogens (AIEgens) for Tunable Organelle-Specific Imaging and Dynamic Tracking in Nanometer Scale
    Yanzi Xu, Dongfeng Dang, Ning Zhang, Jianyu Zhang, Ruohan Xu, Zhi Wang, Yu Zhou, Haoke Zhang, Haixiang Liu, Zhiwei Yang et al. · 2022 · ACS Nano
49. A Cofactor‐Substrate‐Based Supramolecular Fluorescent Probe for the Ultrafast Detection of Nitroreductase under Hypoxic Conditions
    Yang Jiao, Lei Zhang, Xu Gao, Wen Si, Chunying Duan · 2019 · Angewandte Chemie International Edition
50. Mitochondria-targetable small molecule fluorescent probes for the detection of cancer-associated biomarkers: A review
    Xue Qing Yu, Yunong Huang, Yunqi Tao, Li Fan, Yuewei Zhang · 2023 · Analytica Chimica Acta
51. New trends of molecular probes based on the fluorophore 4-amino-1,8-naphthalimide
    Lin Zhou, Lijuan Xie, Chuanhao Liu, Yi Xiao · 2019 · Chinese Chemical Letters
52. Advances in targeted therapy for tumor with nanocarriers: A review
    Hongxia Cheng, Juan Liao, Yuhan Ma, Muhammad Tariq Sarwar, Huaming Yang · 2025 · Materials Today Bio
53. A self-immobilizing near-infrared fluorogenic probe for sensitive imaging of extracellular enzyme activity in vivo
    Yuyao Li, Heng Song, Chenghong Xue, Zhijun Fang, Liqin Xiong, Hexin Xie · 2020 · Chemical Science
54. Aptamer Generated by Cell-SELEX for Specific Targeting of Human Glioma Cells
    Ningqin Lin, Liang Li Wu, Xing Xu, Qiaoyi Wu, Yuzhe Wang, Haicong Shen, Yanling Song, Hongyao Wang, Zhi Zhu, De-Zhi Kang et al. · 2020 · ACS Applied Materials & Interfaces
55. NIR-II cell endocytosis-activated fluorescent probes for in vivo high-contrast bioimaging diagnostics
    Yue He, Shangfeng Wang, Peng Yu, Kui Yan, Jiang Ming, Chenzhi Yao, Zuyang He, Ahmed Mohamed El‐Toni, Aslam Khan, Xinyan Zhu et al. · 2021 · Chemical Science
56. A Molecular‐Splicing Strategy for Constructing a Near‐Infrared Fluorescent Probe for UDP‐Glucuronosyltransferase 1A1
    Xiangge Tian, Tao Liu, Yinhua Ma, Jian Gao, Lei Feng, Jingnan Cui, Tony D. James, Xiaochi Ma · 2021 · Angewandte Chemie International Edition
57. A photostable Si-rhodamine-based near-infrared fluorescent probe for monitoring lysosomal pH during heat stroke
    Guojiang Mao, Zhenzhen Liang, Guang-Qi Gao, Yingying Wang, Xinyu Guo, Li Su, Hua Zhang, Qiujuan Ma, Guisheng Zhang · 2019 · Analytica Chimica Acta
58. Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells
    Shohei Uchinomiya, Naoya Matsunaga, Koichiro Kamoda, Ryosuke Kawagoe, Akito Tsuruta, Shigehiro Ohdo, Akio Ojida · 2020 · Chemical Communications
59. Recent advances in fluorescent probes for extracellular pH detection and imaging
    Yi Chen · 2020 · Analytical Biochemistry
60. Development and application of several fluorescent probes in near infrared region
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61. Lessons in Organic Fluorescent Probe Discovery
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62. Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models
    Na He, Song Bai, Yan Lin Huang, Yanlong Xing, Lingxin Chen, Fabiao Yu, Changjun Lv · 2019 · Analytical Chemistry
63. A metal-free near-infrared fluorescent probe for tracking the glucose-induced fluctuations of carbon monoxide in living cells and zebrafish
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64. Recent advances in organic-dye-based photoacoustic probes for biosensing and bioimaging
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65. Naphthalimide Fluorescent Skeleton for Facile and Accurate Quantification of Glutathione
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66. Chiral MOF Derived Wearable Logic Sensor for Intuitive Discrimination of Physiologically Active Enantiomer
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67. Near-infrared fluorescence probe with a large stokes shift for visualizing hydrogen peroxide in ulcerative colitis mice
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68. Real-time imaging of alkaline phosphatase activity of diabetes in mice via a near-infrared fluorescent probe
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69. Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase
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70. A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters
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71. A water-soluble dual-site fluorescent probe for the rapid detection of cysteine with high sensitivity and specificity
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72. Dual-Functional AIE Fluorescent Probe for Visualization of Lipid Droplets and Photodynamic Therapy of Cancer
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73. Chemical Probes Reveal Sirt2’s New Function as a Robust “Eraser” of Lysine Lipoylation
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74. Controllable synthesis of exceptionally small-sized superparamagnetic magnetite nanoparticles for ultrasensitive MR imaging and angiography
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75. Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery
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76. Orderly Self‐Assembly of Organic Fluorophores for Sensing and Imaging
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77. Azo-based near-infrared fluorescent theranostic probe for tracking hypoxia-activated cancer chemotherapy in vivo
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78. Recent progress in two-photon small molecule fluorescent probes for enzymes
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79. RETRACTED ARTICLE: Comparison and evaluation of the performance of graphene-based biosensors
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80. In Vitro Light‐Up Visualization of a Subunit‐Specific Enzyme by an AIE Probe via Restriction of Single Molecular Motion
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81. Azetidine-Containing Heterospirocycles Enhance the Performance of Fluorophores
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82. γ-Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor
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83. Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics
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84. Penta-fluorophenol: a Smiles rearrangement-inspired cysteine-selective fluorescent probe for imaging of human glioblastoma
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85. Hemicyanine‐Based Near‐Infrared Activatable Probes for Imaging and Diagnosis of Diseases
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86. Biosensors for Caspase-3: From chemical methodologies to biomedical applications
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87. Point-of-care Ratiometric Fluorescence Imaging of Tissue for the Diagnosis of Ovarian Cancer
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89. Recent Progress in Small Spirocyclic, Xanthene-Based Fluorescent Probes
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93. Fluorescent probes for bioactive detection and imaging of phase II metabolic enzymes
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94. Monitoring Neuroinflammation with an HOCl-Activatable and Blood–Brain Barrier Permeable Upconversion Nanoprobe
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95. Rigid π-Extended Boron Difluoride Complex with Mega-Stokes Shift for Bioimaging
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96. Activatable nanoscale metal-organic framework for ratiometric photoacoustic imaging of hydrogen sulfide and orthotopic colorectal cancer in vivo
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97. Promoted NIR‐II Fluorescence by Heteroatom‐Inserted Rigid‐Planar Cores for Monitoring Cell Therapy of Acute Lung Injury
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98. A novel 2,5-bis(benzo[d]thiazol-2-yl)phenol scaffold-based ratiometric fluorescent probe for sensing cysteine in aqueous solution and serum
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99. Tetrahedron Probes for Ultrasensitive In Situ Detection of Telomerase and Surface Glycoprotein Activity in Living Cells
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100. Recent advances in near-infrared-II organic J-aggregates for bio-applications
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