Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

Cites (365)

Items 201–363 of 363

1. Real time detection of ESKAPE pathogens by a nitroreductase-triggered fluorescence turn-on probe
   Shengnan Xu, Qinghua Wang, Qingyang Zhang, Leilei Zhang, Limin Zuo, Jian‐Dong Jiang, Hai‐Yu Hu · 2017 · Chemical Communications
2. Biochemical and in Vivo Characterization of a Small, Membrane-Permeant, Caspase-Activatable Far-Red Fluorescent Peptide for Imaging Apoptosis
   Kristin E. Bullok, Dustin J. Maxwell, Aparna Hemant Kesarwala, Seth T. Gammon, Julie L. Prior, Margaret Snow, Sam Stanley, David R Piwnica-Worms · 2007 · Biochemistry
3. Sensitive Fluorescence Probe with Long Analytical Wavelengths for γ-Glutamyl Transpeptidase Detection in Human Serum and Living Cells
   Lihong Li, Wen Sheng Shi, Zhe Wang, Qiuyu Gong, Huimin Ma · 2015 · Analytical Chemistry
4. Discriminating Live and Dead Cells in Dual-Color Mode with a Two-Photon Fluorescent Probe Based on ESIPT Mechanism
   Minggang Tian, Jie Sun, Yonghe Tang, Baoli Dong, Weiying Lin · 2017 · Analytical Chemistry
5. Human ovarian tumors express gamma-glutamyl transpeptidase.
   Marie H. Hanigan, Henry F. Frierson, Janet Elizabeth Brown, Mark A. Lovell, Peyton T. Taylor · 1994 · PubMed
6. Activatable Near-Infrared Fluorescent Probe for In Vivo Imaging of Fibroblast Activation Protein-alpha
   Jinbo Li, Kai Chen, Hongguang Liu, Kai Cheng, Meng Yang, Jiping Zhang, Jonathan D. Cheng, Yan Zhang, Zhen Cheng · 2012 · Bioconjugate Chemistry
7. Genomic Structure and Transcriptional Regulation of the Rat, Mouse, and Human Carboxylesterase Genes
   Masakiyo Hosokawa, Tomomi Furihata, Yumiko Yaginuma, Naoko Yamamoto, Nao Koyano, Ayako Fujii, 永原 佑子, Testuo Satoh, Kan Chiba · 2007 · Drug Metabolism Reviews
8. An enzyme-activatable probe with a self-immolative linker for rapid and sensitive alkaline phosphatase detection and cell imaging through a cascade reaction
   Hongmei Zhang, Chenglong Xu, Jie Liu, Xiaohong Li, Lin Guo, Xinming Li · 2015 · Chemical Communications
9. Ligand selectivity and competition between enzymes in silico
   Antonio Macchiarulo, Irene Nobeli, Janet M. Thornton · 2004 · Nature Biotechnology
10. Detection of MMP-2 and MMP-9 Activity in Vivo with a Triple-Helical Peptide Optical Probe
    Walter John Akers, Baogang J. Xu, Hyeran Lee, Gail P. Sudlow, Gregg B. Fields, Samuel A. Achilefu, Wilson Barry Edwards · 2012 · Bioconjugate Chemistry
11. A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase 1
    Zhaoming Liu, Lei Feng, Guang‐Bo Ge, Xia Lv, Jie Hou, Yun‐Feng Cao, Jingnan Cui, Ling Yang · 2014 · Biosensors and Bioelectronics
12. Real-Time Video Imaging of Protease Expression In Vivo
    Lei Zhu, Jin Xie, Magdalena Swierczewska, Fan Zhang, Qimeng Quan, Ying Ma, Xuexun Fang, Kwangmeyung Kim, Seulki Lee, Xiaoyuan Shawn Chen · 2011 · Theranostics
13. Activatable Near‐Infrared Probe for Fluorescence Imaging of γ‐Glutamyl Transpeptidase in Tumor Cells and In Vivo
    Zhiliang Luo, Liandong Feng, Ruibing An, Guanfu Duan, Runqi Yan, Hua Shi, Jian He, Zhengyang Zhou, Changge Ji, Hong‐Yuan Chen et al. · 2017 · Chemistry - A European Journal
14. Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS
    Nan Li, C.J. Kuo, Guillem Paniagua, Hans van den Elst, Martijn Verdoes, Lianne I. Willems, Wouter A. van der Linden, Mark Ruben, Eric van Genderen, Jacob Gubbens et al. · 2013 · Nature Protocols
15. Dark Quenched Matrix Metalloproteinase Fluorogenic Probe for Imaging Osteoarthritis Development in Vivo
    Seulki Lee, Kyeongsoon Park, Seung Young Lee, Ju Hee Ryu, Jong Woong Park, Hyung Jun Ahn, Ick Chan Kwon, Inchan Youn, Kwangmeyung Kim, Kuiwon Choi · 2008 · Bioconjugate Chemistry
16. Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV
    Haruna Onoyama, Mako Kamiya, Yugo Kuriki, Toru Komatsu, Hiroyuki Abé, Yosuke Tsuji, Koichi Yagi, Yukinori Yamagata, Susumu Aikou, Masato Nishida et al. · 2016 · Scientific Reports
17. A turn-on fluorescent probe for tumor hypoxia imaging in living cells
    Qi Cai, Tao Yu, Weiping P. Zhu, Yufang F. Xu, Xuhong H. Qian · 2015 · Chemical Communications
18. Toward a Chemical Marker for Inflammatory Disease: A Fluorescent Probe for Membrane-Localized Thioredoxin
    Min Hee Lee, Hyun Mi Jeon, Ji Hye Han, Nayoung Park, Chulhun Kang, Jonathan L. Sessler, Jong Seung Kim · 2014 · Journal of the American Chemical Society
19. Spatially Resolved Monitoring of Neutrophil Elastase Activity with Ratiometric Fluorescent Reporters
    Stefanie M. Gehrig, Marcus Alexander Mall, Carsten Schultz · 2012 · Angewandte Chemie International Edition
20. A rapid response “Turn-On” fluorescent probe for nitroreductase detection and its application in hypoxic tumor cell imaging
    Jian Xu, Sun Shaobo, Qian Li, Ying Yue, Yingdong Li, Shijun Shao · 2014 · The Analyst
21. A highly sensitive and selective fluorescence off–on probe for the detection of intracellular endogenous tyrosinase activity
    Xiaofeng Wu, Xiaohua Li, Hongyu Li, Wen Sheng Shi, Huimin Ma · 2017 · Chemical Communications
22. Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes
    Marcin Poręba, Wioletta Rut, Matej Vizovišek, Katarzyna M. Groborz, Paulina Kasperkiewicz, Darren Finlay, Kristiina Vuori, Vito Türk, Boris Turk, Guy S. Salvesen et al. · 2018 · Chemical Science
23. “AND” luminescent “reactive” molecular logic gates: a gateway to multi-analyte bioimaging and biosensing
    Anthony Romieu · 2014 · Organic & Biomolecular Chemistry
24. A FRET probe with AIEgen as the energy quencher: dual signal turn-on for self-validated caspase detection
    Youyong Yuan, Ruoyu Zhang, Xiamin Cheng, Shidang Xu, Bin Liu · 2016 · Chemical Science
25. Ultrasensitive Detection of Aminopeptidase N Activity in Urine and Cells with a Ratiometric Fluorescence Probe
    Xinyuan He, Yanhui Xu, Wen Sheng Shi, Huimin Ma · 2017 · Analytical Chemistry
26. Enzymatic Cleavage and Subsequent Facile Intramolecular Transcyclization for in Situ Fluorescence Detection of γ-Glutamyltranspetidase Activities
    Hongjuan Tong, Y. Zheng, Li Zhou, Xiangmin Li, Rui Qian, Rui Wang, Jianhong Zhao, Kaiyan Lou, Wei Wang · 2016 · Analytical Chemistry
27. Recent advances in the development of synthetic chemical probes for glycosidase enzymes
    Helen M. Burke, Thorfinnur Gunnlaugsson, Eoin Martin Scanlan · 2015 · Chemical Communications
28. A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling
    Rahul S. Kathayat, Pablo D. Elvira, Bryan C. Dickinson · 2016 · Nature Chemical Biology
29. Highly Selective Fluorescent Probe Based on Hydroxylation of Phenylboronic Acid Pinacol Ester for Detection of Tyrosinase in Cells
    Huihui Li, Wei Liu, Fengyuan Zhang, Xinyue Zhu, Liqiu Huang, Haixia Zhang · 2017 · Analytical Chemistry
30. Design and Development of Enzymatically Activatable Photosensitizer Based on Unique Characteristics of Thiazole Orange
    Yuichiro Koide, Yasuteru Urano, Akira Yatsushige, Kenjiro Hanaoka, Takuya Terai, Tetsuo Nagano · 2009 · Journal of the American Chemical Society
31. A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo
    Xuexiang Zhang, Hao Wu, Peng Li, Zongjin Qu, Mingqian Tan, Keli Han · 2016 · Chemical Communications
32. Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N
    Xinyuan He, Yiming Hu, Wen Sheng Shi, Xiaohua Li, Huimin Ma · 2017 · Chemical Communications
33. Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase
    Ryu J. Iwatate, Mako Kamiya, Keitaro Umezawa, Hiroki Kashima, Mamiko Nakadate, Ryosuke Kojima, Yasuteru Urano · 2018 · Bioconjugate Chemistry
34. Detection of Intestinal Cancer by Local, Topical Application of a Quenched Fluorescence Probe for Cysteine Cathepsins
    Ehud Segal, Tyler R. Prestwood, Wouter A. van der Linden, Yaron Carmi, Nupur Bhattacharya, Nimali P. Withana, Martijn Verdoes, Aida Habtezion, Edgar G. Engleman, Matthew S. Bogyo · 2015 · Chemistry & Biology
35. Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma
    Giuseppe Carlucci, Brandon D. Carney, Christian Brand, Susanne Kossatz, Christopher P. Irwin, Sean Carlin, Edmund J. Keliher, Wolfgang Weber, Thomas Reiner · 2015 · Molecular Imaging and Biology
36. Efficient Two-Photon Fluorescent Probe for Glutathione S-Transferase Detection and Imaging in Drug-Induced Liver Injury Sample
    Jing Zhang, Zhen Jin, Xiaoxiao Hu, Hong‐Min Meng, Jin Li, Xiaobing Zhang, Hong‐Wen Liu, Tanggang Deng, Shan Yao, Lili Feng · 2017 · Analytical Chemistry
37. A new fluorescent probe with a large turn-on signal for imaging nitroreductase in tumor cells and tissues by two-photon microscopy
    Zhan-Rong Liu, Yonghe Tang, An Xu, Weiying Lin · 2016 · Biosensors and Bioelectronics
38. A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study
    Ziru Dai, Lei Feng, Qiang Jin, Hai-Ling Margaret Cheng, Yan Li, Jing Ning, Yang Yu, Guang‐Bo Ge, Jingnan Cui, Ling Yang · 2016 · Chemical Science
39. 7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off–on probe for highly sensitive and selective detection of nitroreductase
    Zhao Li, Xinghui Gao, Wen Sheng Shi, Xiaohua Li, Huimin Ma · 2013 · Chemical Communications
40. A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2
    Benhua Wang, Jiangli Fan, Xianwu Wang, Hao Zhu, Jingyun Wang, Huiying Mu, Xiaojun Peng · 2014 · Chemical Communications
41. Selective Activity‐Based Probes for Cysteine Cathepsins
    Anja Watzke, Gregor Kosec, Maik Kindermann, Volker Jeske, Hans Peter Nestler, Vito Türk, Boris Turk, K. Ulrich Wendt · 2007 · Angewandte Chemie International Edition
42. Highly Specific near-Infrared Fluorescent Probe for the Real-Time Detection of β‑Glucuronidase in Various Living Cells and Animals
    Yinzhu Jin, Xiangge Tian, Lingling Jin, Yonglei Cui, Tao Liu, Zhenlong Yu, Xiaokui Huo, Jingnan Cui, Cheng‐Peng Sun, Chao Wang et al. · 2018 · Analytical Chemistry
43. Fluorescence-Quenched Substrates for Live Cell Imaging of Human Glucocerebrosidase Activity
    Anuj K. Yadav, David L. Shen, Xiaoyang Shan, Xu He, Allison R. Kermode, David J. Vocadlo · 2015 · Journal of the American Chemical Society
44. A New Strategy for Fluorogenic Esterase Probes Displaying Low Levels of Non‐specific Hydrolysis
    Sungwoo Kim, Hyun‐Jin Kim, Yongdoo Choi, Youngmi Kim · 2015 · Chemistry - A European Journal
45. A fluorescent assay for γ-glutamyltranspeptidase via aggregation induced emission and its applications in real samples
    Xianfeng Hou, Fang Zeng, Shuizhu Wu · 2016 · Biosensors and Bioelectronics
46. Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy
    Shu-Hou Yang, Qi Sun, Hao Xiong, Shiyu Liu, Behrooz Moosavi, Wen‐Chao Yang, Guang‐Fu Yang · 2017 · Chemical Communications
47. A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model
    Yaping Liu, Huilong Ma, Liangwei Zhang, Yajing Cui, Xiaoting Liu, Jianguo Fang · 2015 · Chemical Communications
48. Simultaneous Intracellular β- d -Glucosidase and Phosphodiesterase I Activities Measurements Based on A Triple-Signaling Fluorescent Probe
    Yinhui Li, Hao Wang, Jishan Li, Jing Zheng, Xinhua Xu, Ronghua Yang · 2011 · Analytical Chemistry
49. A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems
    Li‐Wei Zou, Ping Wang, Xing‐Kai Qian, Lei Feng, Yang Yu, Dandan Wang, Qiang Jin, Jie Hou, Zhihong Liu, Guang‐Bo Ge et al. · 2016 · Biosensors and Bioelectronics
50. A novel near-infrared fluorescent probe for selectively sensing nitroreductase (NTR) in an aqueous medium
    Youmin Shi, Sichun Zhang, Xinrong Zhang · 2013 · The Analyst
51. A near-infrared fluorescent probe for monitoring tyrosinase activity
    Xiaohua Li, Wen Sheng Shi, Suming Chen, Jia Jia, Huimin Ma, Otto S. Wolfbeis · 2010 · Chemical Communications
52. Molecular engineering of two-photon fluorescent probes for bioimaging applications
    Hong‐Wen Liu, Yongchao Liu, Peng Wang, Xiaobing Zhang · 2017 · Methods and Applications in Fluorescence
53. γ-Glutamyltransferase: Nucleotide sequence of the human pancreatic cDNA
    Céline Courtay, Thierry Oster, France Michelet, Athanase Visvikis, Marc F. Diederich, Maria Wellman, Gérard Siest · 1992 · Biochemical Pharmacology
54. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
    Xu Qiu, Zhong Liu, Weiyan Shao, Xing Liu, Da-Ping Jing, Yanjun Yu, Lin‐Kun An, Shi‐Liang Huang, Xianzhang Bu, Zhi‐Shu Huang et al. · 2008 · Bioorganic & Medicinal Chemistry
55. Virginia Orange: A Versatile, Red-Shifted Fluorescein Scaffold for Single- and Dual-Input Fluorogenic Probes
    Jonathan B. Grimm, Todd D. Gruber, Gloria Ortiz, Timothy A. Brown, Luke D. Lavis · 2015 · Bioconjugate Chemistry
56. A carboxylesterase-selective ratiometric fluorescent two-photon probe and its application to hepatocytes and liver tissues
    Sang Jun Park, Hyo Won Lee, Hyeri Kim, Chulhun Kang, Hwan Myung Kim · 2016 · Chemical Science
57. Near-Infrared Fluorescence Probes for Enzymes Based on Binding Affinity Modulation of Squarylium Dye Scaffold
    Daihi Oushiki, Hirotatsu Kojima, Yuki Takahashi, Toru Komatsu, Takuya Terai, Kenjiro Hanaoka, Makiya Nishikawa, Yoshinobu Takakura, Tetsuo Nagano · 2012 · Analytical Chemistry
58. Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases
    Yugo Kuriki, Mako Kamiya, Hidemasa Kubo, Toru Komatsu, Tasuku Ueno, Ryo Tachibana, Kento Hayashi, Kenjiro Hanaoka, Suguru Yamashita, Takeaki Ishizawa et al. · 2018 · Journal of the American Chemical Society
59. In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate
    Hai‐Yu Hu, Divya Vats, Matej Vizovišek, Lovro Kramer, Catherine Germanier, K. Ulrich Wendt, Markus Rudin, Boris Turk, Oliver Plettenburg, Carsten Schultz · 2014 · Angewandte Chemie International Edition
60. Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues
    Huatang Zhang, Peng Xiao, Yin Ting Wong, Wei Shen, Mohit Chhabra, Raoul Peltier, Yin Jiang, Yonghe He, Jun Hui He, Yi Tan et al. · 2017 · Biomaterials
61. 2-Nitroimidazole based fluorescent probes for nitroreductase; monitoring reductive stress in cellulo
    X. Ao, Sandra A. Bright, Neil C. Taylor, Robert B. P. Elmes · 2017 · Organic & Biomolecular Chemistry
62. Fluorescent light-up probe with aggregation-induced emission characteristics for in vivo imaging of cell apoptosis
    Haibin Shi, Na Zhao, Dan Ding, Jing Liang, Ben Zhong Tang, Bin Liu · 2013 · Organic & Biomolecular Chemistry
63. An Autoimmolative Spacer Allows First‐Time Incorporation of a Unique Solid‐State Fluorophore into a Detection Probe for Acyl Hydrolases
    Xiao‐bing Zhang, Michael Waibel, Jens Hasserodt · 2009 · Chemistry - A European Journal
64. Ultrasensitive Fluorescent Probes Reveal an Adverse Action of Dipeptide Peptidase IV and Fibroblast Activation Protein during Proliferation of Cancer Cells
    Qiuyu Gong, Wen Sheng Shi, Lihong Li, Xiaofeng Wu, Huimin Ma · 2016 · Analytical Chemistry
65. A fast response and red emission probe for mammalian thioredoxin reductase
    Huilong Ma, Junmin Zhang, Zhenzhe Zhang, Yaping Liu, Jianguo Fang · 2016 · Chemical Communications
66. Detecting and Imaging of γ-Glutamytranspeptidase Activity in Serum, Live Cells, and Pathological Tissues with a High Signal-Stability Probe by Releasing a Precipitating Fluorochrome
    Juan Ouyang, Yongfei Li, Ping Wu, Wen‐Li Jiang, Hong‐Wen Liu, Chunyan Li · 2018 · ACS Sensors
67. An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells
    Nahyun Kwon, Myoung Ki Cho, Sang Jun Park, Dayoung Kim, Sang‐Jip Nam, Lei Cui, Hwan Myung Kim, Juyoung Yoon · 2016 · Chemical Communications
68. An optimized ratiometric fluorescent probe for sensing human UDP-glucuronosyltransferase 1A1 and its biological applications
    Xia Lv, Guang‐Bo Ge, Lei Feng, Johanna Troberg, Lianghai Hu, Jie Hou, Hai-Ling Margaret Cheng, Ping Wang, Zhaoming Liu, Moshe Finel et al. · 2015 · Biosensors and Bioelectronics
69. Fibroblast-activation protein: a single marker that confidently differentiates morpheaform/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma
    Ossama M. Abbas, Joanna E. Richards, Meera Mahalingam · 2010 · Modern Pathology
70. Novel live imaging techniques of cellular functions and in vivo tumors based on precise design of small molecule-based ‘Activatable’ fluorescence probes
    Yasuteru Urano · 2012 · Current Opinion in Chemical Biology
71. Asymmetric Rhodamine‐Based Fluorescent Probe for Multicolour In Vivo Imaging
    Ryu J. Iwatate, Mako Kamiya, Yasuteru Urano · 2016 · Chemistry - A European Journal
72. A BODIPY-based two-photon fluorescent probe validates tyrosinase activity in live cells
    Kondapa Naidu Bobba, Miae Won, Inseob Shim, Nithya Velusamy, Zhigang Yang, Junle Qu, Jong Seung Kim, Sankarprasad Bhuniya · 2017 · Chemical Communications
73. In Vivo Imaging of Intraperitoneally Disseminated Tumors in Model Mice by Using Activatable Fluorescent Small-Molecular Probes for Activity of Cathepsins
    Tomohiko Fujii, Mako Kamiya, Yasuteru Urano · 2014 · Bioconjugate Chemistry
74. Light-Up Probes Based on Fluorogens with Aggregation-Induced Emission Characteristics for Monoamine Oxidase-A Activity Study in Solution and in Living Cells
    Wei Shen, Jiajun Yu, Jingyan Ge, Ruoyu Zhang, Feng Cheng, Xuefeng Li, Yong Fan, Shian Yu, Bin Liu, Qing xia Zhu · 2015 · ACS Applied Materials & Interfaces
75. Environmentally Robust Rhodamine Reporters for Probe-based Cellular Detection of the Cancer-linked Oxidoreductase hNQO1
    Quinn A. Best, Amanda E. Johnson, Bijeta Prasai, Alexandra Rouillere, Robin L. McCarley · 2015 · ACS Chemical Biology
76. Advances in fluorescent-image guided surgery
    Mark J. Landau, Daniel J. Gould, Ketan M. Patel · 2016 · Annals of Translational Medicine
77. In vivo imaging of alkaline phosphatase in tumor-bearing mouse model by a promising near-infrared fluorescent probe
    Hong‐Wen Liu, Xiaoxiao Hu, Longmin Zhu, Ke Li, Qiming Rong, Lin Yuan, Xiaobing Zhang, Weihong Tan · 2017 · Talanta
78. Activatable Near-Infrared Fluorescent Probe for Dipeptidyl Peptidase IV and Its Bioimaging Applications in Living Cells and Animals
    Tao Liu, Jing Ning, Bo Wang, Bin Dong, Song Li, Xiangge Tian, Zhenlong Yu, Yulin Peng, Chao Wang, Xinyu Zhao et al. · 2018 · Analytical Chemistry
79. Near‐Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid
    Qingqing Miao, David Yeo, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu, Kanyi Pu · 2018 · Angewandte Chemie
80. Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation
    Nimali P. Withana, Toshinobu Saito, Xiaowei Ma, Megan Garland, Changhao Liu, Hisanori Kosuge, Myriam Amsallem, Martijn Verdoes, Leslie O. Ofori, Michael P. Fischbein et al. · 2016 · Journal of Nuclear Medicine
81. Optical Surgical Navigation for Precision in Tumor Resections
    Stefan Harmsen, Nutte Tarn Teraphongphom, Michael F. Tweedle, James P. Basilion, Eben Lloyd Rosenthal · 2017 · Molecular Imaging and Biology
82. An Optimized Activity-Based Probe for the Study of Caspase-6 Activation
    Laura E. Edgington‐Mitchell, Bram J. van Raam, Martijn Verdoes, Christoph Wierschem, Guy S. Salvesen, Matthew S. Bogyo · 2012 · Chemistry & Biology
83. Clinical significance of serum high‐molecular‐mass alkaline phosphatase, alkaline phosphatase–lipoprotein‐X complex, and intestinal variant alkaline phosphatase
    Paul L. Wolf · 1994 · Journal of Clinical Laboratory Analysis
84. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes
    Marcin Poręba, Rigmor Solberg, Wioletta Rut, Ngoc Nguyen Lunde, Paulina Kasperkiewicz, Scott J. Snipas, Marko Mihelič, Vito Türk, Boris Turk, Guy S. Salvesen et al. · 2016 · Cell chemical biology
85. The first ratiometric fluorescent probes for aminopeptidase N cell imaging
    Laizhong Chen, Wei Sun, Jing Li, Zhenzhen Liu, Zhao Ma, Wei Zhang, Lüpei Du, Wenfang Xu, Hao Fang, Minyong Li · 2012 · Organic & Biomolecular Chemistry
86. Induction of NQO1 in Cancer Cells
    Asher Begleiter, Jeanne Fourie · 2004 · Methods in enzymology on CD-ROM/Methods in enzymology
87. A novel application of cyclic voltammetry for direct investigation of metabolic intermediates in microsomal azo reduction
    Shmuel Zbáida, Walter G. Levine · 1991 · Chemical Research in Toxicology
88. A turn-on fluorescent probe for detection of tyrosinase activity
    Changcheng Wang, Shengyong Yan, Rong Huang, Shuo Feng, Boshi Fu, Xiaocheng Weng, Xiang Zhou · 2013 · The Analyst
89. Indocyanine-Based Activatable Fluorescence Turn-On Probe for γ-Glutamyltranspeptidase and Its Application to the Mouse Model of Colon Cancer
    Seokan Park, Soo-Yeon Lim, Sang Mun Bae, Sang-Yeob Kim, Seung‐Jae Myung, Hae-Jo Kim · 2016 · ACS Sensors
90. Discovery of Bioluminogenic Probes for Aminopeptidase N Imaging
    Jing Li, Laizhong Chen, Wenxiao Wu, Wei Zhang, Zhao Ma, Yanna Cheng, Lüpei Du, Minyong Li · 2014 · Analytical Chemistry
91. A biotinylated piperazine-rhodol derivative: a ‘turn-on’ probe for nitroreductase triggered hypoxia imaging
    Ying Mei Zhou, Kondapa Naidu Bobba, Xue Wei Lv, Dan Yang, Nithya Velusamy, Jun Feng Zhang, Sankarprasad Bhuniya · 2016 · The Analyst
92. A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin
    Xia Lv, Lei Feng, Chun‐Zhi Ai, Jie Hou, Ping Wang, Li‐Wei Zou, Jie Cheng, Guang‐Bo Ge, Jingnan Cui, Ling Yang · 2017 · Journal of Medicinal Chemistry
93. A panel of subunit-selective activity-based proteasome probes
    Martijn Verdoes, Lianne I. Willems, Wouter A. van der Linden, Boudewijn A. Duivenvoorden, Gijsbert A. van der Marel, Bogdan I. Florea, Alexei F. Kisselev, Herman S. Overkleeft · 2010 · Organic & Biomolecular Chemistry
94. In Vivo Optical Imaging of Membrane-Type Matrix Metalloproteinase (MT-MMP) Activity
    Lei Zhu, Fan Zhang, Ying Ma, Gang Liu, Kwangmeyung Kim, Xuexun Fang, Seulki Lee, Xiaoyuan Shawn Chen · 2011 · Molecular Pharmaceutics
95. Prodrug-Inspired Probes Selective to Cathepsin B over Other Cysteine Cathepsins
    Morshed Alam Chowdhury, Ignace A. Moya, Shardul Bhilocha, Cody C. McMillan, Brady G. Vigliarolo, Ingeborg Zehbe, Christopher P. Phenix · 2014 · Journal of Medicinal Chemistry
96. “Double gating” – a concept for enzyme-responsive imaging probes aiming at high tissue specificity
    Maxime Prost, Jens Hasserodt · 2014 · Chemical Communications
97. Enzyme-Specific Doxorubicin Drug Beacon as Drug-Resistant Theranostic Molecular Probes
    Lye Lin Lock, Zidu Tang, Daniel Keith, Claudia D. Reyes, Honggang Cui · 2015 · ACS Macro Letters
98. A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease
    Liangwei Zhang, Shoujiao Peng, Jinyu Sun, Juan Yao, Jie Kang, Yuesong Hu, Jianguo Fang · 2017 · Chemical Science
99. Supramolecular assembly affording a ratiometric two-photon fluorescent nanoprobe for quantitative detection and bioimaging
    Peng Wang, Cheng Zhang, Hong‐Wen Liu, Mengyi Xiong, Sheng‐Yan Yin, Yue Yang, Xiaoxiao Hu, Xia Yin, Xiaobing Zhang, Weihong Tan · 2017 · Chemical Science
100. A robust, high-sensitivity stealth probe for peptidases
     Oliver Thorn‐Seshold, Monica Vargas Sanchez, Sean McKeon, Jens Hasserodt · 2012 · Chemical Communications
101. Cancer cell-targeted two-photon fluorescence probe for the real-time ratiometric imaging of DNA damage
     Hua Zhang, Kui Wang, Xiaopeng Xuan, Qingzhang Lv, Yamin Nie, Hai‐Ming Guo · 2016 · Chemical Communications
102. Poly( m -phenylenediamine)-Based Fluorescent Nanoprobe for Ultrasensitive Detection of Matrix Metalloproteinase 2
     Zhe Wang, Xiaohua Li, Duan Feng, Lihong Li, Wen Sheng Shi, Huimin Ma · 2014 · Analytical Chemistry
103. Hydrogel-Framed Nanofiber Matrix Integrated with a Microfluidic Device for Fluorescence Detection of Matrix Metalloproteinases-9
     Sang Won Han, W. Koh · 2016 · Analytical Chemistry
104. A two-photon fluorescent probe for nitroreductase imaging in living cells, tissues and zebrafish under hypoxia conditions
     Baoping Zhai, Wei Hu, Jinyu Sun, Siyu Chi, Yidi Lei, Fang Zhang, Cheng Zhong, Zhihong Liu · 2017 · The Analyst
105. An Optimized Two‐Photon Fluorescent Probe for Biological Sensing and Imaging of Catechol‐O‐Methyltransferase
     Ping Wang, Yangliu Xia, Li‐Wei Zou, Xing‐Kai Qian, Tongyi Dou, Qiang Jin, Shi‐Yang Li, Yang Yu, Dandan Wang, Qun Luo et al. · 2017 · Chemistry - A European Journal
106. Developing Activity Localization Fluorescence Peptide Probe Using Thiol-Ene Click Reaction for Spatially Resolved Imaging of Caspase-8 in Live Cells
     Wei Liu, Sijia Liu, Yongqing Kuang, Feng-Yan Luo, Jian‐Hui Jiang · 2016 · Analytical Chemistry
107. Colorectal Cancer Diagnosis Using Enzyme‐Sensitive Ratiometric Fluorescence Dye and Antibody–Quantum Dot Conjugates for Multiplexed Detection
     Youngrong Park, Yeon‐Mi Ryu, Taejun Wang, Yebin Jung, Sohee Kim, Sekyu Hwang, Joonhyuck Park, Dong‐Jun Bae, Jaeil Kim, Heejo Moon et al. · 2017 · Advanced Functional Materials
108. A novel fibroblast activation protein-targeted near-infrared fluorescent off–on probe for cancer cell detection, in vitro and in vivo imaging
     Jie Xing, Qiuyu Gong, Ruifen Zou, Zihou Li, Yuanzhi Xia, Zhangsen Yu, Yufan Ye, Lingchao Xiang, Aiguo Wu · 2018 · Journal of Materials Chemistry B
109. Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action
     Einat Kisin‐Finfer, Shiran Ferber, Rachel Blau, Ronit Satchi‐Fainaro, Doron Shabat · 2014 · Bioorganic & Medicinal Chemistry Letters
110. Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures andin silicomodeling
     Dong Dong, Baojian Wu, Diana S‐L Chow, Ming Hu · 2012 · Drug Metabolism Reviews
111. A Ratiometric Fluorescent Probe for Imaging of the Activity of Methionine Sulfoxide Reductase A in Cells
     Nikolai Makukhin, Vyacheslav Tretyachenko, Jackob Moskovitz, Jiří Míšek · 2016 · Angewandte Chemie International Edition
112. A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off–on fluorescent probe for covalent labelling of thioredoxin reductase
     Lei Huang, Yu Chen, Baoxia Liang, Bengang Xing, Gesi Wen, Shuni Wang, Xin Yue, Cuige Zhu, Jun Du, Xianzhang Bu · 2014 · Chemical Communications
113. Substitutions for Glu-537 of β -galactosidase from Escherichia coli cause large decreases in catalytic activity
     Jie Yuan, Mercedes Martinez-Bilbao, Reuben E. Huber · 1994 · Biochemical Journal
114. A Two‐photon Fluorescent Probe for Intracellular Detection of Tyrosinase Activity
     Shengyong Yan, Rong Huang, Changcheng Wang, Yimin Zhou, Jiaqi Wang, Boshi Fu, Xiaocheng Weng, Xiang Zhou · 2012 · Chemistry - An Asian Journal
115. Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe
     Hyeran Lee, Walter John Akers, Philip P. Cheney, Wilson Barry Edwards, Kexian Liang, Joseph P. Culver, Samuel A. Achilefu · 2009 · Journal of Biomedical Optics
116. Recharging oxidative protein repair: Catalysis by methionine sulfoxide reductases towards their amino acid, protein, and model substrates
     Tarrago, L., Gladyshev, V. N. · 2012 · Biochemistry (Moscow)
117. A ratiometric fluorescent probe for quantification of alkaline phosphatase in living cells
     Zhenxing Lu, Jiasheng Wu, Weimin Liu, Guang-You Zhang, Pengfei Wang · 2016 · RSC Advances
118. Multi-Förster Resonance Energy Transfer-Based Fluorescent Probe for Spatiotemporal Matrix Metalloproteinase-2 and Caspase-3 Imaging
     Hong Bo Cheng, Shiying Li, Haoran Zheng, Chu‐Xin Li, Bo‐Ru Xie, Ke-Wei Chen, Bin Li, Xian‐Zheng Zhang · 2017 · Analytical Chemistry
119. Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting
     Jiangli Fan, Shigang Guo, Suzhen Wang, Yao Kang, Qichao Yao, Jia Wang, Xue Gao, Hongjiang Wang, Jianjun Du, Xiaojun Peng · 2017 · Chemical Communications
120. Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR
     Baoxia Liang, Weiyan Shao, Cuige Zhu, Gesi Wen, Xin Yue, Ruimin Wang, Junmin Quan, Jun Du, Xianzhang Bu · 2015 · ACS Chemical Biology
121. Synthesis and Characterization of 2‐(2′‐hydroxy‐5′‐chlorophenyl)‐6‐chloro‐4(3 H)‐Quinazolinone‐Based Fluorogenic Probes for Cellular Imaging of Monoamine Oxidases
     Junxin Aw, Qing Shao, Yanmei Yang, Tingting Jiang, Chungyen Ang, Bengang Xing · 2010 · Chemistry - An Asian Journal
122. Selective Fluorescence Probes for Dipeptidyl Peptidase ActivityFibroblast Activation Protein and Dipeptidyl Peptidase IV
     Koon Siew Lai, Nan‐Hui Ho, Jonathan D. Cheng, Ching‐Hsuan Tung · 2007 · Bioconjugate Chemistry
123. Dual enzyme-responsive “turn-on” fluorescence sensing systems based on in situ formation of 7-hydroxy-2-iminocoumarin scaffolds
     Sylvain Debieu, Anthony Romieu · 2015 · Organic & Biomolecular Chemistry
124. Synthesis of a far-red fluorophore and its use as an esterase probe in living cells
     Samantha R. Levine, Kimberly E. Beatty · 2015 · Chemical Communications
125. Glutamate, glutamine, glutathione, and related compounds.
     Alton Meister · 1985 · PubMed
126. A novel role for placental leucine aminopeptidase (P-LAP) as a determinant of chemoresistance in endometrial carcinoma cells
     Chihiro Kondo, Kiyosumi Shibata, Mikio Terauchi, Hiroaki Kajiyama, Kazuhiko Ino, Seiji Nomura, Akihiro Nawa, Shigehiko Mizutani, Fumitaka Kikkawa · 2005 · International Journal of Cancer
127. Design and synthesis of near-infrared fluorescence-enhancement probes for the cancer-specific enzyme hNQO1
     Changyu Zhang, Bei-Bei Zhai, Tao Peng, Zelin Zhong, Lianbin Xu, Qiang-Zhe Zhang, Luyuan Li, Long Yi, Zhen Xi · 2017 · Dyes and Pigments
128. Ratiometric Fluorescent Probe for Imaging of Pantetheinase in Living Cells
     Yiming Hu, Hongyu Li, Wen Sheng Shi, Huimin Ma · 2017 · Analytical Chemistry
129. Highly Selective Red-Emitting Fluorescent Probe for Imaging Cancer Cells in Situ by Targeting Pim-1 Kinase
     Shigang Guo, Jiangli Fan, Benhua Wang, Ming Xiao, Yueqing Li, Jianjun Du, Xiaojun Peng · 2017 · ACS Applied Materials & Interfaces
130. Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate
     Nan‐Hui Ho, Ralph Weissleder, Ching‐Hsuan Tung · 2006 · Bioorganic & Medicinal Chemistry Letters
131. A Ultrasensitive Near‐Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine
     Qiuyu Gong, Ruifen Zou, Jie Xing, Lingchao Xiang, Renshuai Zhang, Aiguo Wu · 2018 · Advanced Science
132. A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging
     Sovy Chao, Éric Krejci, Véronique Bernard, Jacqueline Leroy, Ludovic Jean, Pierre‐Yves Renard · 2016 · Chemical Communications
133. Tagging Live Cells that Express Specific Peptidase Activity with Solid‐State Fluorescence
     Maxime Prost, Laurence Canaple, Jacques Samarut, Jens Hasserodt · 2014 · ChemBioChem
134. Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues
     Michael W. Beck, Rahul S. Kathayat, Candace M. Cham, Eugene B. Chang, Bryan C. Dickinson · 2017 · Chemical Science
135. An efficient two-photon fluorescent probe for measuring γ-glutamyltranspeptidase activity during the oxidative stress process in tumor cells and tissues
     Peng Wang, Jing Zhang, Hong‐Wen Liu, Xiaoxiao Hu, Lili Feng, Xia Yin, Xiaobing Zhang · 2017 · The Analyst
136. Fluorescent and bioluminescent nanoprobes for in vitro and in vivo detection of matrix metalloproteinase activity
     Hawon Lee, Young‐Pil Kim · 2015 · BMB Reports
137. Strategies in the Design of Small‐Molecule Fluorescent Probes for Peptidases
     Laizhong Chen, Jing Li, Lüpei Du, Minyong Li · 2014 · Medicinal Research Reviews
138. Detection of ubiquitin–proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development
     Holger Kramer, Benjamin Nicholson, Benedikt Mathias Kessler, Mikael Altun · 2012 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
139. A NIR turn-on fluorescent probe applied in cytochrome P450 reductase detection and hypoxia imaging in tumor cells
     Lei Cui, Yan‐Ping Shi, Shuping Zhang, Luliang Yan, Huan Zhang, Zhenran Tian, Yingying Gu, Ting Guo, Junhai Huang · 2016 · Dyes and Pigments
140. An anthracenecarboximide fluorescent probe for in vitro and in vivo ratiometric imaging of endogenous alpha- l -fucosidase for hepatocellular carcinoma diagnosis
     Xianfeng Hou, Peng Jin, Fang Zeng, Changmin Yu, Shuizhu Wu · 2016 · Materials Chemistry Frontiers
141. Molecular imaging of Cathepsin E-positive tumors in mice using a novel protease-activatable fluorescent probe
     Wael R. Abd‐Elgaliel, Zobeida Cruz‐Monserrate, Craig D. Logsdon, Ching‐Hsuan Tung · 2011 · Molecular BioSystems
142. Pyroglutamate aminopeptidase 1 may be an indicator of cellular inflammatory response as revealed using a sensitive long-wavelength fluorescent probe
     Qiuyu Gong, Lihong Li, Xiaofeng Wu, Huimin Ma · 2016 · Chemical Science
143. Rational Design of Matrix Metalloproteinase-13 Activatable Probes for Enhanced Specificity
     Lei Zhu, Ying Ma, Dale O. Kiesewetter, Ye Wang, Lixin Lang, Seulki Lee, Gang Niu, Xiaoyuan Shawn Chen · 2013 · ACS Chemical Biology
144. Single-Nucleotide Polymorphism Genotyping of exoS in Pseudomonas aeruginosa Using Dual-Color Fluorescence Hybridization and Magnetic Separation
     Yongjun Tang, Zeeshan Ali, Jianguo Dai, Xiaolong Liu, Yanqi Wu, Zhu Chen, Nongyue He, Song Li, Lijun Wang · 2018 · Journal of Biomedical Nanotechnology
145. Small-molecule probe using dual signals to monitor leucine aminopeptidase activity
     Hey Young Yoon, So Hee Shim, Luck Ju Baek, Jong‐In Hong · 2011 · Bioorganic & Medicinal Chemistry Letters
146. Bioreductive Markers for Hypoxic Cells: 2-Nitroimidazoles with Biotinylated 1-Substituents
     Richard J. Hodgkiss, John Parrick, Manuchehr Porssa, Michael R.L. Stratford · 1994 · Journal of Medicinal Chemistry
147. A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells
     Tian Qiu, Rahul S. Kathayat, Yang Cao, Michael W. Beck, Bryan C. Dickinson · 2017 · Biochemistry
148. A Small‐Molecule FRET Reporter for the Real‐Time Visualization of Cell‐Surface Proteolytic Enzyme Functions
     Jing Mu, Fang Liu, Muhammad Shafiq Rajab, Meng Shi, Shuang Li, Chi Ching Goh, Lei Lu, Qing‐Hua Xu, Bin Liu, Lai Guan Ng et al. · 2014 · Angewandte Chemie
149. An Inhibitor of Glutathione S‐Transferase Omega 1 that Selectively Targets Apoptotic Cells
     Nicholas J. Pace, Daniel R. Pimental, Eranthie Weerapana · 2012 · Angewandte Chemie International Edition
150. Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity
     Suvendu Biswas, Brandon S. McCullough, Shuangyu Ma, Dollie LaJoie, Colin W. Russell, David Garrett Brown, June L. Round, Katharine S. Ullman, Matthew A. Mulvey, Amy M. Barrios · 2017 · Chemical Communications
151. Monomolecular pyrenol-derivatives as multi-emissive probes for orthogonal reactivities
     Björn Finkler, Iris Riemann, Michael Vester, Andreas Grüter, Frank Stracke, Gregor Jung · 2016 · Photochemical & Photobiological Sciences
152. Enzyme Function Discovery
     Debra Dunaway‐Mariano · 2008 · Structure
153. Proteases and the regulation of biological processes
     Jeremy Saklatvala, Hideaki Nagase, Guy S. Salvesen · 2003
154. A bestatin-based fluorescent probe for aminopeptidase N cell imaging
     Hui Chen, Hui Wang, Xiaojun Qin, Chen Chen, Lu Feng, Laizhong Chen, Lüpei Du, Minyong Li · 2015 · Chinese Chemical Letters
155. A Correction to the Editors' Choice Summary Titled “Keeping Bone Where Bone Belongs” by Leslie K. Ferrarelli
     2013 · Science Signaling
156. Affinity labeling of the proteasome by a belactosin A derived inhibitor
     Makoto Hasegawa, Kazuhiro Kinoshita, Chika Nishimura, Umechiyo Matsumura, Masafumi Shionyu, Shun-ichi Ikeda, Tamio Mizukami · 2008 · Bioorganic & Medicinal Chemistry Letters
157. Serum pyroglutamyl aminopeptidase activity: a promising novel biomarker candidate for liver cirrhosis
     M. J. Megias, F. Alba-Araguez, Juan de Dios Luna, Francisco Vives, M. Ramirez-Sanchez · 2015 · Endocrine Regulations
158. Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition
     Yongsheng Yu, Jiang Xia · 2016 · Science China Chemistry
159. Fluorescence triggered by ligand-protein hydrophobic interaction
     Zhenzhen Liu, Lüpei Du, Minyong Li · 2013 · Science China Chemistry
160. Fluorogenic Disassembly of Self-Quenched Near-Infrared Nanoparticles Enables Matrix Metalloproteinase Detection
     Wei Tang, Zhibin Zhao, Zhe‐Xiong Lian, Gaolin Liang · 2018 · Journal of Biomedical Nanotechnology
161. Issue Information
     2018 · Wiley Interdisciplinary Reviews Computational Statistics
162. Radiosensitization by erlotinib and veliparib in esophageal squamous cell cancer.
     Alexander C. Whitley, Tiffiny S. Cooper, Anusha Angajala, Hoa Quang Trummell, Josh Jackson, James A. Bonner, Eddy Shih-Hsin Yang · 2014 · Journal of Clinical Oncology
163. Untitled work
     Wajchenberg · 2000 · 10.1002/(sici)1097-0142(20000215)88:4