A hollow fiber system for simple generation of human brain organoids
Abstract
Here we present a novel approach to engineer hiPSC-derived brain organoids within hollow fibers in a simple and high throughput manner by integrating biomaterials with stem cell biology.
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Several laboratories have grown a wide range of organoids in polysaccharides such as alginate or alginate-chitosan mixtures.
“In addition to organoids grown in naturally-derived proteins, several laboratories have grown a wide range of organoids in polysaccharides such as alginate or alginate-chitosan mixtures.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [101]
Organoid types grown in alginate include human lung, human brain, murine intestinal, human intestinal, human pancreatic, and human and murine vascular.
“Organoid types grown in alginate include human lung99,100, human brain101, murine intestinal102, human intestinal102,103, human pancreatic104, and human and murine vascular105.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [101]
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References 28 · Cited by 55
- Authors
- Zhu, Y., Wang, L., Yin, F., Yu, Y., Wang, Y., Liu, H., Wang, H., Sun, N., Liu, H., & Qin, J.
- Affiliations
- Dalian Institute of Chemical Physics (CN)
- Shanghai Medical College of Fudan University (CN)
- Venue
- Integr. Biol.
- Publisher
- Oxford University Press (OUP)
- Published
- 2017
- Volume
- 9
- Issue
- 9
- Pages
- 774-781
- ISSN
- 1757-9694 (ISSN-L)
- 1757-9708
- OpenAlex
- W2742059672
- Cited by
- 55
- References
- 28
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 6
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Integrative Biology (publishedVersion)
- PubMed (publishedVersion)
- Dalian Institute of Chemical Physics, CAS Institutional Repository (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- brain organoids, hollow fiber bioreactor, human induced pluripotent stem cells, neuronal differentiation
- MeSH terms
- Alginates, Biocompatible Materials, Brain, Hexuronic Acids, Humans, Materials Testing, Models, Neurological, Organoids, Developmental Biology, Glucuronic Acid, Tissue Engineering, Biomimetics, Organogenesis, Pluripotent Stem Cells, Neurogenesis, Lab-On-A-Chip Devices
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