Native extracellular matrix-derived semipermeable, optically transparent, and inexpensive membrane inserts for microfluidic cell culture
Open accessAbstract
This paper presents a new type of cell culture membranes engineered from native extracellular matrix (ECM) materials that are thin, semipermeable, optically transparent, and amenable to integration into microfluidic cell culture devices.
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References 36 · Cited by 95
- Authors
- Mondrinos, M. J., Yi, Y.-S., Wu, N.-K., Ding, X., & Huh, D.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Huh, Dongeun
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 17
- Issue
- 18
- Pages
- 3146-3158
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC5782796
- OpenAlex
- W2747681349
- Cited by
- 95
- References
- 36
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 16 · 2022: 12 · 2021: 15 · 2020: 11 · 2019: 10 · 2018: 6
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (DP2HL127720)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- semipermeable membranes, microfluidic cell culture, vitrification, basement membrane mimicry, optical transparency, membrane rigidity, porosity, cell-matrix interactions, perfusion culture, histogenesis, in vitro tissue models, cell adhesion signaling
- MeSH terms
- Animals, Cell Adhesion, Cells, Cultured, Equipment Design, Extracellular Matrix, Humans, Membranes, Artificial, Permeability, Cell Culture Techniques, Microfluidic Analytical Techniques, Mice, Elastic Modulus, Human Umbilical Vein Endothelial Cells
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