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Cited by 62Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesRNA Interference and Gene Delivery

Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau

Open access
Gao, Na, Chu, Ting-Ting, Li, Qian-Qian, Lim, Yeh-Jun, Qiu, Tian, Ma, Meng-Rong, Hu, Zhi-Wen, Yang, Xi-Fei +3 more·2017·RSC Advances
DOI 10.1039/c7ra05347a
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Abstract

HyT-Tau-CPP reduced Tau levels in Alzheimer's disease (AD) mouse model, and appeared to be a promising candidate for AD treatment.

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Crossref · 10.1039/c7ra05347a

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  • Exchanging the HALO reactive linker for the Tau-interacting peptide (C-terminal region of tubulin) induced efficient degradation of Tau.

    “In an attempt to make the system more applicable and remove the need to create HALO-fusions, the HALO reactive linker was exchanged for the Alzheimer’s disease-related protein Tau-interacting peptide (the C-terminal region of tubulin). This induced efficient degradation of Tau [60].”

    From Advances in targeted degradation of endogenous proteins (2019) · cites this paper as [60]

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References 41 · Cited by 62

Authors
Gao, N., Chu, T.-T., Li, Q.-Q., Lim, Y.-J., Qiu, T., Ma, M.-R., Hu, Z.-W., Yang, X.-F., Chen, Y.-X., Zhao, Y.-F., & Li, Y.-M.
Affiliations
  • Tsinghua University (CN)
  • Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education)
  • Key Laboratory of Modern Toxicology of Shenzhen
Corresponding author
Chen, Yong-Xiang
ORCID
Venue
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Published
2017
Volume
7
Issue
64
Pages
40362-40366
ISSN
2046-2069 (ISSN-L)
DOI
10.1039/c7ra05347a
OpenAlex
W2748160025
Cited by
62
References
41
Citations by year
2026: 7 · 2025: 8 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 2
FWCI
2.43
Type
journal article
Language
en
Open access
Licence
Locations
RSC Advances (publishedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
tau protein, Alzheimer's disease, protein degradation, tau aggregation, mouse models of Alzheimer's disease, drug candidates

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