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Cited by 198Polymer Surface Interaction StudiesHydrogels: synthesis, properties, applicationsGlycosylation and Glycoproteins Research

Mucins as multifunctional building blocks of biomaterials

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Petrou, Georgia, Crouzier, Thomas·2018·Biomaterials Science
DOI 10.1039/c8bm00471d
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Abstract

Mucins glycoproteins are emerging as a multifunctional building block for biomaterials with diverse applications in chemistry and biomedicine.

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  • A mucin capsule can protect probiotic bacteria against low pH and proteolytic activity in the stomach, so bacteria enter the gut where local microflora can break down mucins.

    “For example, a mucin capsule can protect probiotic bacteria against low pH and proteolytic activity in the stomach, so the bacteria enter the gut, where the local microflora can break down the mucins [65].”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [65]

    The “What lies ahead” section proposes that mucin encapsulation could protect probiotic bacteria in the stomach and release them in the intestines, where microflora can degrade mucins. The citing sentence presents that proposed protection as an established capability (“can protect”), which is stronger than the source’s hypothetical wording. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Snail mucus of different snail species is proposed for the treatment of chronic lesions, skin conditions, post-surgical infections, stomach ulcers, etc.

    “Snail mucus of different snail species is proposed for the treatment of chronic lesions, skin conditions, post-surgical infections, stomach ulcers, etc. [62,65,66].”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [65]

    The “On synthetic” section says snail and slug mucus preparations have been used for skin wounds and inflammations, supporting the skin-related part of the claim. The paper does not identify snail mucus as a proposed treatment for chronic lesions or post-surgical infections; in “What lies ahead,” it discusses gastric ulcers in connection with pig gastric mucin, not snail mucus. Page numbers were not available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • It was noted that the skin of workers became softer after contact with snail secretions during cleaning and manual handling of the animals, and small cuts healed quickly, without infection or scarring.

    “It was noted that the skin of workers became softer after contact with snail secretions during cleaning and manual handling of the animals. In addition, small cuts healed quickly, without infection or scarring [12,27,30,62,65].”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [65]

    The 'On synthetic' section describes historical use of snail and slug mucus for skin wounds and says its components may contribute to skin rejuvenation and wound healing (page unavailable). It does not report observations of workers handling snails, softer skin, rapid healing of small cuts, or healing without infection or scarring. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Mice overexpressing mucin or mucin fragments showed protection against pathogens in both gut and lungs.

    “The hypothesis is based on the experiment findings showing that mice overexpressing mucin or mucin fragments showed a remarkable protection ability against pathogens in both the gut and the lungs.”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [65]

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Cited by

Sorted by citations

Authors
Petrou, G., & Crouzier, T.
Affiliations
KTH Royal Institute of Technology (SE)
Corresponding author
Crouzier, Thomas
ORCID
Venue
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Published
2018
Volume
6
Issue
9
Pages
2282-2297
ISSN
  • 2047-4830 (ISSN-L)
  • 2047-4849
DOI
10.1039/c8bm00471d
OpenAlex
W2884140402
Cited by
198
References
3
Citations by year
2026: 18 · 2025: 41 · 2024: 32 · 2023: 17 · 2022: 37 · 2021: 27 · 2020: 19 · 2019: 7
FWCI
1.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomaterials Science (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Stiftelsen för Strategisk Forskning (FFL15-0072)
  • Svenska Forskningsrådet Formas (2015-1316)
  • Vetenskapsrådet (2014-6203)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Keywords
mucin, biomaterials, mucus gel, antifouling coatings, selective filters, artificial tears, artificial saliva, cosmetics, drug delivery, natural detergents, lubrication, barrier properties, glycoproteins
MeSH terms
Animals, Biocompatible Materials, Humans, Lubrication, Mucins

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