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Cited by 56Bacterial Genetics and BiotechnologyTrace Elements in HealthMetalloenzymes and iron-sulfur proteins

Handling of nutrient copper in the bacterial envelope

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Stewart, Louisa J., Thaqi, Denis, Kobe, Bostjan, McEwan, Alastair G., Waldron, Kevin J., Djoko, Karrera Y.·2019·Metallomics
DOI 10.1039/c8mt00218e
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Abstract

The insertion of copper into bacterial cuproenzymes in vivo does not always require a copper-binding metallochaperone – why?

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  • For Zn2+ and Cu+, the notional free metal pool is less than one atom per cell at equilibrium, and metal mobility relies on ligand exchange chemistry.

    “For Zn2+ and Cu+, however, the notional free metal pool is less than one atom per cell at equilibrium, and the mobility of metals relies on ligand exchange chemistry.3,31,32”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [31]

    The Introduction (page unavailable) says Cu and Zn are buffered at low available concentrations and that metals move between binding sites through associative exchange reactions. It does not state that the notional free Zn²⁺ or Cu⁺ pool is less than one atom per cell at equilibrium. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Stewart, L. J., Thaqi, D., Kobe, B., McEwan, A. G., Waldron, K. J., & Djoko, K. Y.
Affiliations
  • Newcastle University (GB)
  • The University of Queensland (AU)
  • School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre
  • Durham University (GB)
Corresponding author
Djoko, Karrera Y.
ORCID
Venue
Metallomics
Publisher
Oxford University Press (OUP)
Published
2019
Volume
11
Issue
1
Pages
50-63
ISSN
  • 1756-5901 (ISSN-L)
  • 1756-591X
DOI
10.1039/c8mt00218e
OpenAlex
W2897183428
Cited by
56
References
1
Citations by year
2026: 4 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 1
FWCI
1.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Metallomics (publishedVersion)
  • PubMed (publishedVersion)
  • Durham Research Online (Durham University) (acceptedVersion)
  • Durham Research Online (Durham University) (acceptedVersion, other-oa)
  • Durham Research Online (Durham University) (submittedVersion, cc-by)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
  • Royal Society (Research Grant RSG\R1\180044, 098375/Z/12/Z)
  • National Health and Medical Research Council (Principal Research Fellowship (APP1110971), Program Grant 1071659)
  • Newcastle University (Research Excellence Academy Studentship)
  • Wellcome Trust (098375/Z/12/Z)
  • Department of Education and Training (Research Training Program Scholarship)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
Keywords
copper, copper enzymes, metallochaperone, copper trafficking, bacterial cell envelope, metalation, copper toxicity, respiration
MeSH terms
Nutrients, Bacteria, Bacterial Infections, Bacterial Proteins, Biological Transport, Copper, Humans, Nitrite Reductases, Oxidoreductases, Superoxide Dismutase, Metallochaperones

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