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Functional metabolomics discover pentose and glucuronate interconversion pathways as promising targets for Yang Huang syndrome treatment with Yinchenhao Tang

Sun, Hui, Zhang, Ai-hua, Song, Qi, Fang, Heng, Liu, Xing-yuan, Su, Jing, Yang, Le, Yu, Meng-die, Wang, Xi-jun·2018·RSC Advances
DOI 10.1039/c8ra06553ePMC PMC9089300
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Abstract

Yinchenhao Tang (YCHT), a classic traditional Chinese medicine (TCM) formulae, plays an important role in the treatment of Yang Huang syndrome (YHS).

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Crossref · 10.1039/c8ra06553e

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Figures

Fig. 1 Multivariate data analysis of the serum metabolite data. 2D score plot of PCA for control and YHS group in the positive ion mode (ESI+) (a) and negative ion mode (ESI−) (b) 3D PCA score plots based on serum metabolites discriminating control and YHS group in the positive ion mode (c) and negative ion mode (d). Collecting the data of the positive ion and negative ion pattern of blood samples.
Fig. 1 Multivariate data analysis of the serum metabolite data. 2D score plot of PCA for control and YHS group in the positive ion mode (ESI+) (a) and negative ion mode (ESI−) (b) 3D PCA score plots based on serum metabolites discriminating control and YHS group in the positive ion mode (c) and negative ion mode (d). Collecting the data of the positive ion and negative ion pattern of blood samples.CC BY-NC · PubMed Central
Fig. 2 Identification of the chemical structures and mass fragments of d-glucuronic acid.
Fig. 2 Identification of the chemical structures and mass fragments of d-glucuronic acid.CC BY-NC · PubMed Central
Fig. 3 Heat map visualization for serum samples from the control and YHS group.
Fig. 3 Heat map visualization for serum samples from the control and YHS group.CC BY-NC · PubMed Central
Fig. 4 The principal components analysis score plots of control, YHS, and YCHT groups in the positive ion mode (a) and negative ion mode (b).
Fig. 4 The principal components analysis score plots of control, YHS, and YCHT groups in the positive ion mode (a) and negative ion mode (b).CC BY-NC · PubMed Central
Fig. 5 Heat map and histogram visualization for the treatment of YCHT on YHS. Bar chart of IPA canonical pathways visualization of the phenotypic characterization of YHS (a); metabolic enrichment analysis of the YHS group using the metaboAnalyst 3.0 online database (b); correlation analysis of tentatively identified metabolites (c).
Fig. 5 Heat map and histogram visualization for the treatment of YCHT on YHS. Bar chart of IPA canonical pathways visualization of the phenotypic characterization of YHS (a); metabolic enrichment analysis of the YHS group using the metaboAnalyst 3.0 online database (b); correlation analysis of tentatively identified metabolites (c).CC BY-NC · PubMed Central
Fig. 6 The process of d-glucuronic acid as a key molecule to bind unconjugated bilirubin via pentose and glucuronate interconversions pathway.
Fig. 6 The process of d-glucuronic acid as a key molecule to bind unconjugated bilirubin via pentose and glucuronate interconversions pathway.CC BY-NC · PubMed Central

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Citations

Cites

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Metadata

Authors
Sun, H., Zhang, A.-H., Song, Q., Fang, H., Liu, X.-Y., Su, J., Yang, L., Yu, M.-D., & Wang, X.-J.
Affiliations
National Chinmedomics Research Center
ORCID
Wang, Xi-jun
Venue
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Published
2018
Volume
8
Issue
64
Pages
36831-36839
ISSN
2046-2069
DOI
10.1039/c8ra06553e
PMC
PMC9089300
Cited by
89
References
1
Language
en
Licence
creativecommons.org/licenses/by-nc/3.0/ (vor, 303 d)

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