Bioengineering a pre-vascularized pouch for subsequent islet transplantation using VEGF-loaded polylactide capsules
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The effectiveness of cell transplantation can be improved by optimization of the transplantation site.
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Incorporating VEGF-releasing capsules into a pre-vascularization strategy or transplanting islets within VEGF-releasing hydrogels further improved vessel formation.
“Incorporating vascular endothelial growth factor (VEGF)-releasing capsules into a similar pre-vascularization strategy152 or transplanting islets within VEGF-releasing hydrogels153 were shown to further improve vessel formation.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [152]
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- Authors
- Kasoju, N., Pátíková, A., Wawrzynska, E., Vojtíšková, A., Sedlačík, T., Kumorek, M., Pop-Georgievski, O., Sticová, E., Kříž, J., & Kubies, D.
- Affiliations
- Czech Academy of Sciences (CZ)
- Institute of Clinical and Experimental Medicine (CZ)
- Institute of Macromolecular Chemistry Czech Academy of Sciences
- Charles University (CZ)
- Corresponding author
- Kříž, Jan
- Kubies, Dana
- ORCID
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 8
- Issue
- 2
- Pages
- 631-647
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W2983223004
- Cited by
- 36
- References
- 57
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 10 · 2023: 7 · 2022: 4 · 2021: 8 · 2020: 3
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-12-12)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biomaterials Science (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Agentura Pro Zdravotnický Výzkum České Republiky (16-28254A)
- Ministerstvo Školství, Mládeže a Tělovýchovy (BIOCEV-FAR LQ1604, CZ.1.05/ 1.1.00/02.0109)
- Ministerstvo Zdravotnictví Ceské Republiky (IN00023001)
- Univerzita Karlova v Praze (100217)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- islet transplantation, vascular endothelial growth factor, vascularization, bioengineered tissue
- MeSH terms
- Animals, Blood Glucose, Capsules, Diabetes Mellitus, Experimental, Injections, Intraperitoneal, Male, Particle Size, Polyesters, Rats, Inbred Lew, Streptozocin, Molecular Structure, Islets of Langerhans Transplantation, Neovascularization, Physiologic, Vascular Endothelial Growth Factors, Rats, Bioengineering
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