An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells
Abstract
TR-OCl exhibits ultra-high sensitivity towards HOCl with a 7000-fold enhancement in the fluorescence ratio ( I 589 / I 477 ) and a detection limit of 1.29 nM, which is one of the highest recorded so far.
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References 59 · Cited by 44
- Authors
- Duan, Q., Zheng, G., Li, Z., Cheng, K., Zhang, J., Yang, L., Jiang, Y., Zhang, H., He, J., & Sun, H.
- Affiliations
- Guangdong University of Technology (CN)
- City University of Hong Kong (HK)
- Corresponding author
- Zhang, Huatang
- He, Jun
- Sun, Hongyan
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 7
- Issue
- 33
- Pages
- 5125-5131
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2962787344
- Cited by
- 44
- References
- 59
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 10 · 2021: 9 · 2020: 8 · 2019: 6
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21602033, 21702143, 21807014)
- Natural Science Foundation of Guangxi Province (2016GXNSFBA380123)
- Research Grants Council, University Grants Committee (11302415, 11304118)
- City University of Hong Kong (9667147)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- hypochlorous acid detection, ratiometric fluorescent probe, aggregation-induced emission, T-bet, live-cell imaging, reaction mechanism, reaction kinetics
- MeSH terms
- RAW 264.7 Cells, Animals, Cell Survival, Energy Transfer, Fluorescent Dyes, Hypochlorous Acid, Spectrometry, Fluorescence, Microscopy, Confocal, Cell Line, Tumor, Mice
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