Cited by 243Advanced Synthetic Organic ChemistryChemical Synthesis and AnalysisOrganic Chemistry Synthesis Methods

The DOI matches its Crossref record.

Robert Robinson Lecture. Retrosynthetic thinking—essentials and examples

Corey, E. J.·1988·Chem. Soc. Rev.

DOI 10.1039/cs9881700111

Open this paper in CoChat — free account

Abstract

E. J. Corey, Chem. Soc. Rev., 1988, 17, 111 DOI: 10.1039/CS9881700111

Integrity signals

Registry

Crossref · 10.1039/cs9881700111

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Sorted by citations

Reticular synthesis and the design of new materials
Yaghi, O. M., O’Keeffe, M., Ockwig, N. W., Chae, H. K., Eddaoudi, M., & Kim, J. (2003) · Nature · doi:10.1038/nature01650 · Cited by 9,235
Supramolecular Synthons in Crystal Engineering—A New Organic Synthesis
Desiraju, G. R. (1995) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199523111 · Cited by 4,858
The atom, the molecule, and the covalent organic framework
Diercks, C. S., & Yaghi, O. M. (2017) · Science · doi:10.1126/science.aal1585 · Cited by 3,489
“Chemists have since exploited these concepts in their efforts to master the craft of synthesizing specificmolecules of varying structure and complexity, which has led to the art and science of total synthesis (2, 3).”
Background
1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis
Ager, D. J., Prakash, I., & Schaad, D. R. (1996) · Chemical Reviews · doi:10.1021/cr9500038 · Cited by 1,628
Covalent Organic Frameworks: Chemistry beyond the Structure
Kandambeth, S., Dey, K., & Banerjee, R. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10334 · Cited by 1,584
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
Kärkäs, M. D., Porco, J. A. J., & Stephenson, C. R. J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00760 · Cited by 1,030
QSAR without borders
Muratov, E. N., Bajorath, J., Sheridan, R. P., Tetko, I. V., Filimonov, D., Poroikov, V., Oprea, T. I., Baskin, I. I., Varnek, A., Roitberg, A., et al. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00098a · Cited by 913
Building co-crystals with molecular sense and supramolecular sensibility
Aakeröy, C. B., & Salmon, D. J. (2005) · CrystEngComm · doi:10.1039/b505883j · Cited by 770
From nature to industry: Harnessing enzymes for biocatalysis
Buller, R., Lutz, S., Kazlauskas, R. J., Šnajdrová, R., Moore, J. C., & Bornscheuer, U. T. (2023) · Science · doi:10.1126/science.adh8615 · Cited by 759
The Molecular Identification of Organic Compounds in the Atmosphere: State of the Art and Challenges
Nozière, B., Kalberer, M., Claeys, M., Allan, J. D., D’Anna, B., Decesari, S., Finessi, E., Glasius, M., Grgić, I., Hamilton, J. F., et al. (2015) · Chemical Reviews · doi:10.1021/cr5003485 · Cited by 711
Systematic exploration of the mechanism of chemical reactions: the global reaction route mapping (GRRM) strategy using the ADDF and AFIR methods
Maeda, S., Ohno, K., & Morokuma, K. (2013) · Physical Chemistry Chemical Physics · doi:10.1039/c3cp44063j · Cited by 615
Organic Synthesis—Where now?
Seebàch, D. (1990) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199013201 · Cited by 579
Supramolekulare Synthone für das Kristall‐Engineering ‐ eine neue organische Synthese
Desiraju, G. R. (1995) · Angewandte Chemie · doi:10.1002/ange.19951072105 · Cited by 545
Enzymes as Green Catalysts for Precision Macromolecular Synthesis
Shoda, S., Uyama, H., Kadokawa, J., Kimura, S., & Kobayashi, S. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00472 · Cited by 552
Supramolecular Inorganic Chemistry: Small Guests in Small and Large Hosts
Müller, A., Reuter, H., & Dillinger, S. (1995) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199523281 · Cited by 537
[NdI2(thf)5], the First Crystallographically Authenticated Neodymium(II) Complex
Bochkarev, M. N., Fedushkin, I. L., Sebastian Dechert, B., Fagin, A. A., & Schumann, H. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010903)40:17 · Cited by 136
The Logic of Chemical Synthesis: Multistep Synthesis of Complex Carbogenic Molecules (Nobel Lecture)
Corey, E. J. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199104553 · Cited by 414
Self-citation
Asymmetric syntheses with chiral oxazaborolidines
Wallbaum, S., & Martens, J. (1992) · Tetrahedron Asymmetry · doi:10.1016/s0957-4166(00)86044-9 · Cited by 382
Advances in the chemistry of metal–organic frameworks
Rosi, N. L., Eddaoudi, M., Kim, J., et al. (2002) · CrystEngComm · doi:10.1039/b203193k · Cited by 297
A review of large language models and autonomous agents in chemistry
Ramos, M. C., Collison, C. J., & White, A. D. (2025) · Chemical Science · doi:10.1039/d4sc03921a · Cited by 274
A new system for catalytic enantioselective reduction of achiral ketones to chiral alcohols. Synthesis of chiral α-hydroxy acids
Corey, E. J., & Bakshi, R. K. (1990) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)94581-7 · Cited by 259
Self-citation
Benzylamines via Iron-Catalyzed Direct Amination of Benzyl Alcohols
Yan, T., Feringa, B. L., & Barta, K. (2015) · ACS Catalysis · doi:10.1021/acscatal.5b02160 · Cited by 243
Supramolecular Synthons and Pattern Recognition
Nangia, A. K., & Desiraju, G. R. (1998) · Topics in current chemistry · doi:10.1007/3-540-69178-2_2 · Cited by 238
Chemistry and Biology of Terpene Trilactones fromGinkgo Biloba
Strømgaard, K., & Nakanishi, K. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200300601 · Cited by 221
A Retrosynthesis Approach for Biocatalysis in Organic Synthesis
de Souza, R. O. M. A., Miranda, L. S. M., & Bornscheuer, U. T. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201702235 · Cited by 210
Organische Synthese — wohin?
Seebàch, D. (1990) · Angewandte Chemie · doi:10.1002/ange.19901021118 · Cited by 205
Emerging Strategies for the Total Synthesis of Inorganic Nanostructures
Buck, M. R., & Schaak, R. E. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201207240 · Cited by 201
The Molecular Industrial Revolution: Automated Synthesis of Small Molecules
Trobe, M., & Burke, M. D. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201710482 · Cited by 198
Enantioselective and practical syntheses of R- and S-fluoxetines
Corey, E. J., & Reichard, G. A. (1989) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)93743-8 · Cited by 188
Self-citation
Biobased Chemicals from Conception toward Industrial Reality: Lessons Learned and To Be Learned
Dapsens, P. Y., Mondelli, C., & Pérez‐Ramírez, J. (2012) · ACS Catalysis · doi:10.1021/cs300124m · Cited by 185
Soft chemistry of ion-exchangeable layered metal oxides
Uppuluri, R., Gupta, A. S., Rosas, A. S., & Mallouk, T. E. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00290d · Cited by 182
Retrosynthesis of Tunable Fluorescent Carbon Dots for Precise Long‐Term Mitochondrial Tracking
Geng, X., Sun, Y., Li, Z., Yang, R., Zhao, Y., Guo, Y., Xu, J., Li, F., Wang, Y., Lu, S., et al. (2019) · Small · doi:10.1002/smll.201901517 · Cited by 175
Blueprinting macromolecular electronics
Palma, C., & Samorı́, P. (2011) · Nature Chemistry · doi:10.1038/nchem.1043 · Cited by 175
Design Constraints in Practical Syntheses of Complex Molecules: Current Status, Case Studies with Carbohydrates and Alkaloids, and Future Perspectives
Hudlický, T. (1996) · Chemical Reviews · doi:10.1021/cr950012g · Cited by 168
Novel electronic effects of remote substituents on the oxazaborolidine-catalyzed enantioselective reduction of ketones
Corey, E. J., & Helal, C. J. (1995) · Tetrahedron Letters · doi:10.1016/0040-4039(95)01961-g · Cited by 158
Self-citation
Radical Addition Reactions
Curran, D. P. (1991) · Elsevier eBooks · doi:10.1016/b978-0-08-052349-1.00108-6 · Cited by 142
Permutation Invariant Graph-to-Sequence Model for Template-Free Retrosynthesis and Reaction Prediction
Tu, Z., & Coley, C. W. (2022) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c00321 · Cited by 160
“Retrosynthetic analysis (Corey, 1988; Corey & Cheng, 1989) and its reverse problem, reaction outcome prediction (Corey & Wipke, 1969), are two fundamental problems in computer-aided organic synthesis.”
Background
A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening
Singh, S., Bruffaerts, J., Vasseur, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms14200 · Cited by 136
Supramolekulare Anorganische Chemie: von Gästen in kleinen und großen Wirten
Müller, A., Reuter, H., & Dillinger, S. (1995) · Angewandte Chemie · doi:10.1002/ange.19951072104 · Cited by 134
Metal–Organic Frameworks Meet Molecularly Imprinted Polymers: Insights and Prospects for Sensor Applications
Lahcen, A. A., Surya, S. G., Bedük, T., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c12842 · Cited by 130
Engineering of Band Gap in Metal–Organic Frameworks by Functionalizing Organic Linker: A Systematic Density Functional Theory Investigation
Pham, H. Q., Mai, T., Pham‐Tran, N., et al. (2014) · The Journal of Physical Chemistry C · doi:10.1021/jp405997r · Cited by 128
Metal-organic frameworks in chromatography
Yusuf, K., Aqel, A., & ALOthman, Z. A. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.04.095 · Cited by 125
Solid‐State Structural Transformations from 2D Interdigitated Layers to 3D Interpenetrated Structures
Medishetty, R., Koh, L. L., Kole, G. K., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104106 · Cited by 123
Retrosynthesis prediction with an interpretable deep-learning framework based on molecular assembly tasks
Wang, Y., Pang, C., Wang, Y., Jin, J., Zhang, J., Zeng, X., Su, R., Zou, Q., & Wei, L. (2023) · Nature Communications · doi:10.1038/s41467-023-41698-5 · Cited by 137
Synthesis of propellane-containing natural products
Pihko, A. J., & Koskinen, A. M. P. (2005) · Tetrahedron · doi:10.1016/j.tet.2005.06.013 · Cited by 109
An eight-step synthesis of epicolactone reveals its biosynthetic origin
Ellerbrock, P., Armanino, N., Ilg, M. K., et al. (2015) · Nature Chemistry · doi:10.1038/nchem.2336 · Cited by 101
Retrosynthetic reaction pathway prediction through neural machine translation of atomic environments
Ucak, U. V., Ashyrmamatov, I., Ko, J., & Lee, J. (2022) · Nature Communications · doi:10.1038/s41467-022-28857-w · Cited by 105
“The idea of reducing the complexity of a desired organic molecule by considering all logical disconnections forms the basis of the retrosynthetic approach 1 – 3 .”
Background
X-Ray crystal structure of a chiral oxazaborolidine catalyst for enantioselective carbonyl reduction
Corey, E. J., Azimioara, M. D., & Sarshar, S. (1992) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)92654-6 · Cited by 100
Self-citation
Asymmetric synthesis of (S)-carbinoxamine. New aspects of oxazaborolidine-catalyzed enantioselective carbonyl reduction
Corey, E. J., & Helal, C. J. (1996) · Tetrahedron Letters · doi:10.1016/0040-4039(96)01198-7 · Cited by 96
Self-citation
Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes
Hutchins, K. M. (2018) · Royal Society Open Science · doi:10.1098/rsos.180564 · Cited by 94
Design and Crystal Structures of Triple Helicates with Crystallographic Idealized D 3 Symmetry: The Role of Side Chain Effect on Crystal Packing
Dong, G., Ke-liang, P., Duan, C., et al. (2002) · Inorganic Chemistry · doi:10.1021/ic0203623 · Cited by 94
Enzymatic strategies for asymmetric synthesis
Hall, M. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00080b · Cited by 92
(+)-1(S), 5(R), 8(S)-8-phenyl-2-azabicyclo[3.3.0]octan-8-ol n,o-methylboronate (2) and its enantiomer, chiral chemzymes which serve as catalysts for their own enantioselective synthesis
Corey, E. J., Chen, C.-P., & Reichard, G. A. (1989) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)93796-7 · Cited by 88
Self-citation
The locks and keys to industrial biotechnology
Wohlgemuth, R. (2009) · New Biotechnology · doi:10.1016/j.nbt.2009.01.002 · Cited by 83
ASKCOS: Open-Source, Data-Driven Synthesis Planning
Tu, Z., Choure, S. J., Fong, M. H., Roh, J., Levin, I., Yu, K., Joung, J. F., Morgan, N. N., Li, S., Sun, X., et al. (2025) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5c00155 · Cited by 84
Thienannulation: Efficient Synthesis of π‐Extended Thienoacenes Applicable to Organic Semiconductors
Takimiya, K., Nakano, M., Kang, M. J., et al. (2012) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201201139 · Cited by 77
Computational Chemical Synthesis Analysis and Pathway Design
Feng, F., Lai, L., & Pei, J. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00199 · Cited by 74
“…produced urea with potassium cyanate and ammonium sulfate (Leicester and Klickstein, 1951), to mid-twentieth century, when chemists such as Robinson, Woodward, and Corey raised it to a qualitatively higher level of sophisticationwith the idea of retrosynthetic analysis (Corey, 1988).”
Background
Die Logik der chemischen Synthese: Vielstufige Synthesen komplexer „carbogener” Moleküle (Nobel‐Vortrag)
Corey, E. J. (1991) · Angewandte Chemie · doi:10.1002/ange.19911030504 · Cited by 75
Self-citation
The first enantioselective syntheses of pure R- and S-isoproterenol
Corey, E. J., & Link, J. O. (1990) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)94578-7 · Cited by 72
Self-citation
Perfluorinated Ligands Induce Meridional Metal Stereochemistry to Generate M8L12, M10L15, and M12L18 Prisms
Kieffer, M., Pilgrim, B. S., Ronson, T. K., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b02445 · Cited by 69
Methodology to establish 1,2- and 1,3-difunctionality for the synthesis of carbohydrate derivates
Ager, D. J., & East, M. B. (1992) · Tetrahedron · doi:10.1016/s0040-4020(01)90970-6 · Cited by 69
Phenyl–Acetylene Bond Assembly: A Powerful Tool for the Construction of Nanoscale Architectures
Jenny, N. M., Mayor, M., & Eaton, T. R. (2011) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201100176 · Cited by 66
Homo- or Heterosynthon? A Crystallographic Study on a Series of New Cocrystals Derived from Pyrazinecarboxamide and Various Carboxylic Acids Equipped with Additional Hydrogen Bonding Sites
Adalder, T. K., Sankolli, R., & Dastidar, P. (2012) · Crystal Growth & Design · doi:10.1021/cg300140w · Cited by 66
Precursor recommendation for inorganic synthesis by machine learning materials similarity from scientific literature
He, T., Huo, H., Bartel, C. J., Wang, Z., Cruse, K., & Ceder, G. (2023) · Science Advances · doi:10.1126/sciadv.adg8180 · Cited by 70
Increase in intricacy—a tool for evaluating organic syntheses
Fuchs, P. L. (2001) · Tetrahedron · doi:10.1016/s0040-4020(01)00474-4 · Cited by 65
Assessing Synthetic Accessibility of Chemical Compounds Using Machine Learning Methods
Podolyan, Y., Walters, M. A., & Karypis, G. (2010) · Journal of Chemical Information and Modeling · doi:10.1021/ci900301v · Cited by 64
Total synthesis of ginkgolide a
Corey, E. J., & Ghosh, A. K. (1988) · Tetrahedron Letters · doi:10.1016/0040-4039(88)85122-0 · Cited by 64
Self-citation
Natural Product Synthesis: Changes over Time
Hoffmann, R. W. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201203319 · Cited by 63
Recent advances in deep learning for retrosynthesis
Zhong, Z., Song, J., Feng, Z., Liu, T., Jia, L., Yao, S., Hou, T., & Song, M. (2023) · Wiley Interdisciplinary Reviews Computational Molecular Science · doi:10.1002/wcms.1694 · Cited by 88
“4 To design more reliable and efficient synthesis routes, retrosynthesis, 4,5 which starts from the desired product and converts it to simpler precursor structures without defining the starting materials beforehand, has been an important technique for solving the planning of organic synthesis.”
Method
The pharmacology of extinction
Huxtable, R. J. (1992) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(92)90002-9 · Cited by 62
Paclitaxel from Primary Taxanes: A Perspective on Creative Invention in Organozirconium Chemistry
Ganem, B., & Franke, R. R. (2007) · The Journal of Organic Chemistry · doi:10.1021/jo070129s · Cited by 61
A new process for the generation of 1,3,2-oxazaborolidines, catalysts for enantioselective synthesis
Corey, E. J., & Link, J. O. (1992) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)74673-9 · Cited by 59
Self-citation
Anharmonic Downward Distortion Following for Automated Exploration of Quantum Chemical Potential Energy Surfaces
Maeda, S., Taketsugu, T., Morokuma, K., et al. (2014) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.20140189 · Cited by 58
Recent trends in covalent organic frameworks (COFs) for carbon dioxide reduction
Sarkar, P., Chowdhury, I. H., Das, S., & Islam, S. M. (2022) · Materials Advances · doi:10.1039/d2ma00600f · Cited by 57
GTA: Graph Truncated Attention for Retrosynthesis
Seo, S.-W., Song, Y. Y., Yang, J. Y., Bae, S., Lee, H., Shin, J., Hwang, S. J., & Yang, E. (2021) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v35i1.16131 · Cited by 63
“Retrosyn-thesis , ﬁrst formulated by (Corey 1988, 1991), is the task of predicting the set of reactant molecules that are synthesized to a given product molecule by ﬁnding the inverse reaction pathway.”
Background
Tools and strategies for constructing cell-free enzyme pathways
Petroll, K., Kopp, D., Care, A., Bergquist, P. L., & Sunna, A. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.11.007 · Cited by 54
Algorithmic Discovery of Tactical Combinations for Advanced Organic Syntheses
Gajewska, E. P., Szymkuć, S., Dittwald, P., Startek, M. P., Popik, O., Młynarski, J., & Grzybowski, B. A. (2019) · Chem · doi:10.1016/j.chempr.2019.11.016 · Cited by 51
Assembly of a Secondary Building Unit (SBU) into Two- and Three-Dimensional Structures in Lanthanide Benzenedicarboxylates
Thirumurugan, A., & Natarajan, S. (2006) · Crystal Growth & Design · doi:10.1021/cg050580h · Cited by 51
[NdI2(thf)5], der erste kristallographisch charakterisierte Neodym(II)-Komplex
Bochkarev, M. N., Fedushkin, I. L., Sebastian Dechert, B., Fagin, A. A., & Schumann, H. (2001) · Angewandte Chemie · doi:10.1002/1521-3757(20010903)113:17 · Cited by 37
Enantioselective total synthesis of ginkgolide derivatives lacking the tert-butyl group, an essential structural subunit for antagonism of platelet activating factor
Corey, E. J., & Rao, K. S. (1991) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)92265-2 · Cited by 50
Self-citation
α‐Hydroxylation of Enolates and Silyl Enol Ethers
Chen, B., Zhou, P., Davis, F. A., et al. (2003) · Organic reactions · doi:10.1002/0471264180.or062.01 · Cited by 49
Machine Learning Applications for Chemical Reactions
Park, S., Han, H., Kim, H., & Choi, S. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202200203 · Cited by 45
Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design
Pang, Y., Vummenthala, A., Mishra, R. K., Park, J. G., Wang, S., Davis, J., Millard, C. B., & Schmidt, J. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007730 · Cited by 46
Mesoporous Composite Nanomaterials for Dye Removal and Other Applications
Marcos−Hernández, M., & Villagrán, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814132-8.00012-5 · Cited by 46
Intramolecular carbometallation of organozinc reagents.
Meyer, C., Marek, I., Courtemanche, G., et al. (1994) · Tetrahedron · doi:10.1016/s0040-4020(01)85661-1 · Cited by 44
The Journey of Schinortriterpenoid Total Syntheses
Yang, Z. J. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00569 · Cited by 43
Novel rare case of 2D + 1D = 2D polycatenation Hg( ii ) coordination polymer
Mahmoudi, G., & Morsali, A. (2008) · CrystEngComm · doi:10.1039/b813701n · Cited by 43
Expanded Porous Metal–Organic Frameworks by SCSC: Organic Building Units Modifying and Enhanced Gas-Adsorption Properties
Fan, W., Lin, H., Xue, Y., et al. (2016) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.6b00278 · Cited by 41
Computer tools for reaction retrieval and synthesis planning in organic chemistry. A brief review of their history, methods, and programs
Ott, M. A., & Noordik, J. H. (1992) · Recueil des Travaux Chimiques des Pays-Bas · doi:10.1002/recl.19921110601 · Cited by 41
Intramolecular Diels–Alder Reactions of Cycloalkenones: Translation of High Endo Selectivity to Trans Junctions
Ross, A. G., Li, X., & Danishefsky, S. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja307708q · Cited by 40
Enabling strategies for step efficient syntheses
Schwan, J., & Christmann, M. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00399h · Cited by 37
Substructure-based neural machine translation for retrosynthetic prediction
Ucak, U. V., Kang, T., Ko, J., & Lee, J. (2021) · Journal of Cheminformatics · doi:10.1186/s13321-020-00482-z · Cited by 39
Synthesis of the adsorbent based on macroporous copolymer MA–DVB beads and its application in purification for the extracts from Ginkgo biloba leaves
Xu, M., Shi, Z., Shi, R., et al. (2000) · Reactive and Functional Polymers · doi:10.1016/s1381-5148(99)00062-0 · Cited by 36
Cobalt Complexes Appended with para- and meta-Arylcarboxylic Acids: Influence of Cation, Solvent, and Symmetry on Hydrogen-Bonded Assemblies
Kumar, G., Aggarwal, H., & Gupta, R. (2012) · Crystal Growth & Design · doi:10.1021/cg3011629 · Cited by 35
Artificial Intelligence for Retrosynthetic Planning Needs Both Data and Expert Knowledge
Strieth‐Kalthoff, F., Szymkuć, S., Molga, K., Aspuru‐Guzik, A., Glorius, F., & Grzybowski, B. A. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c00338 · Cited by 43
Chiral aggregation and spontaneous resolution of thiosemicarbazone metal complexes
Li, M., Sun, Q.-Z., Bai, Y., Duan, C., Zhang, B., & Meng, Q. (2006) · Dalton Transactions · doi:10.1039/b514425f · Cited by 34
A neural network model informs the total synthesis of clovane sesquiterpenoids
Zhang, P., Eun, J., Elkin, M., Zhao, Y., Cantrell, R. L., & Newhouse, T. R. (2023) · Nature Synthesis · doi:10.1038/s44160-023-00271-0 · Cited by 33
“3b, the synthetic route via radical intermediate 8 to clovan-2,9-dione (1) starts from commercially available”
BackgroundMethodInfluential
Simple analogs of ginkgolide b which are highly active antagonists of platelet activating factor
Corey, E. J., & Gavai, A. V. (1989) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)93397-0 · Cited by 32
Self-citation
Designing undergraduate-level organic chemistry instructional problems: Seven ideas from a problem-solving study of practicing synthetic organic chemists
Raker, J. R., & Towns, M. H. (2012) · Chemistry Education Research and Practice · doi:10.1039/c1rp90073k · Cited by 31
“Synthetic planning problems include the retrosynthetic analysis of the target molecule (Corey, 1988, 1991; Corey and Cheng, 1995) and subsequent development of a synthetic pathway(s) while anticipating day-to-day problems.”
Background
Development of chemical and chemo-enzymatic glycosylations
Shoda, S. (2017) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.93.008 · Cited by 31

Authors: Corey, E. J.
Corresponding author: Corey, E. J.
ORCID: Corey, E. J.
Venue: Chem. Soc. Rev.
Publisher: Royal Society of Chemistry (RSC)
Published: 1988
Volume: 17
Issue: 0
Pages: 111-133
ISSN: 0306-0012 (ISSN-L)
1460-4744
DOI: 10.1039/cs9881700111
OpenAlex: W2010754031
Cited by: 243
References: 0
Citations by year: 2026: 14 · 2025: 13 · 2024: 15 · 2023: 16 · 2022: 14 · 2021: 13 · 2020: 5 · 2019: 7 · 2018: 12 · 2017: 7 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 12
FWCI: 9.89
Type: journal article
Language: en
Open access: closed
Locations: Chemical Society Reviews (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Advanced Synthetic Organic Chemistry
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
Keywords: retrosynthesis, organic synthesis planning, synthetic strategies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Robert Robinson Lecture. Retrosynthetic thinking—essentials and examples

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Citations

Cited by

Related

Metadata

Record

About these checks