PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes

Smalley, Joshua P., Adams, Grace E., Millard, Christopher J., Song, Yun, Norris, James K. S., Schwabe, John W. R., Cowley, Shaun Michael, Hodgkinson, James T.·2020·Chemical Communications
DOI 10.1039/d0cc01485k

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  10. PROTACS- targeted protein degradation as a path to precision cancer therapeutics
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  13. BindingDB Entry 50019232: Development of Human Carbonic Anhydrase II Heterobifunctional Degraders.
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  14. BindingDB Entry 50018659: Developments of CRBN-based PROTACs as potential therapeutic agents.
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  15. BindingDB Entry 50013364: Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
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  16. BindingDB Entry 50019825: Developments of PROTACs technology in immune-related diseases.
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  17. BindingDB Entry 50021665: The application of PROTAC in HDAC.
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  18. BindingDB Entry 50021137: HDAC-targeting epigenetic modulators for cancer immunotherapy.
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  19. BindingDB Entry 50021145: Annual review of PROTAC degraders as anticancer agents in 2022.
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  20. BindingDB Entry 50016839: VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives.
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  21. BindingDB Entry 50018797: A bibliometric analysis of PROTAC from 2001 to 2021.
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  22. BindingDB Entry 50017503: Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity.
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  24. BindingDB Entry 50018350: Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs).
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  25. BindingDB Entry 50016856: Medicinal chemistry updates of novel HDACs inhibitors (2020 to present).
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  26. BindingDB Entry 50021668: Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects.
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  27. BindingDB Entry 50021132: Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders.
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  28. HDAC3 degradation to uncover therapeutic vulnerability in colorectal cancer
    Ilaria Cursaro, Gabriele Carullo, Chiara Cosenza, Anita Heiß, K Huebner, Jiazhao Song, Chao Wang, Katharina Erlenbach‐Wuensch, Adrian Koch, Silvia Pasquini et al. · 2026 · European Journal of Medicinal Chemistry
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