Mangiferin protects against alcoholic liver injury via suppression of inflammation-induced adipose hyperlipolysis
Abstract
Adipose dysfunction is closely associated with alcoholic liver disease. The impact of mangiferin on ethanol-induced liver injury and the probable underlying molecular mechanism has not been sufficiently addressed. In the present study, mice were subjected to a chronic plus a single binge ethanol feeding to induce liver injury. In addition, the differentiated adipocytes from primary mouse adipocytes were isolated and used for the mechanism studies. Our study demonstrated that mangiferin protects against ethanol induced adipose hyperlipolysis by restoring PDE3B stability, which is associated with activating the AMPK/TBK1 signaling and suppressing the noncanonical NF-κB activation, leading to the reduction of free fatty acid release and the amelioration of ethanol-induced liver injury. Our findings identify that mangiferin ameliorates alcoholic liver injury via suppression of inflammation-induced adipose hyperlipolysis, suggesting that mangiferin might be a potential effective agent for the management of alcoholic liver injury.
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In vivo studies in rats showed that MGF enhanced antioxidant enzyme levels and inhibited NF-κB p65 activation, reducing inflammation and cell proliferation.
“in vivo studies demonstrated that MGF, administrated in rats, enhanced both antioxidant enzyme levels and inhibited NF-κB p65 activation, showing a significant reduction of inflammation and cell proliferation [40,41].”
From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [41]
Cites
Oxidative Stress and Alcoholic Liver Disease
Wu, D., & Cederbaum, A. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1214370 · Cited by 342 · see citing works
Alcoholic liver disease: pathogenesis and new targets for therapy
Altamirano, J., & Bataller, R. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.134 · Cited by 284 · see citing works
Song, J., Li, J., Hou, F., Wang, X., & Liu, B. (2015) · Metabolism · doi:10.1016/j.metabol.2014.11.008 · Cited by 109 · see citing works
Self-citationMa, J., Karlsen, M. C., Chung, M., Jacques, P. F., Saltzman, E., Smith, C. E., Fox, C. S., & McKeown, N. M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuv047 · Cited by 28 · see citing works
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Zhou, H., Song, S., Lan, X., Li, Y., Yuan, X., Yang, J., Li, M., Cao, T., & Zhang, J. (2023) · ACS Omega · doi:10.1021/acsomega.2c07089 · Cited by 15 · see citing works
Spampinato, M., Carota, G., Sferrazzo, G., Fuochi, V., Distefano, A., Ronsisvalle, S., Sipala, F., Giuffrida, R., Furneri, P. M., Di Rosa, M., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122845 · Cited by 14 · see citing works
“In this regard, in vivo studies demonstrated that MGF, administrated in rats, enhanced both antioxidant enzyme levels and inhibited NF-κB p65 activation, showing a significant reduction of inflammation and cell proliferation [40,41].”
Background
- Authors
- Dong, M., Li, L., Li, G., Song, J., Liu, B., Liu, X., & Wang, M.
- Affiliations
- Hebei Normal University (CN)
- Hebei University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Minzu University of China (CN)
- Corresponding author
- Liu, Xifu
- Wang, Meng
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 11
- Issue
- 10
- Pages
- 8837-8851
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W3087919443
- Cited by
- 26
- References
- 4
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 1 · 2021: 2
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81803762)
- Natural Science Foundation of Hebei Province (H2019205068)
- Minzu University of China (KLEM-KF2018Y03, KLEM-KF2019Y01)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- mangiferin, alcoholic liver injury, free fatty acid release, adipocytes, ethanol-induced liver injury, inflammation
- MeSH terms
- Adipose Tissue, Ethanol, Animals, Disease Models, Animal, Inflammation, Lipolysis, Liver, Liver Diseases, Alcoholic, Male, Mice, Inbred C57BL, Signal Transduction, Adipocytes, Protective Agents, Xanthones, Mice
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