Schisandra chinensis protects against dopaminergic neuronal oxidative stress, neuroinflammation and apoptosis via the BDNF/Nrf2/NF-κB pathway in 6-OHDA-induced Parkinson's disease mice
Abstract
Sch protects against DA neurodegeneration in 6-OHDA-induced PD mice by suppressing oxidative stress, neuroinflammation and apoptosis through the involvement of the BDNF/Nrf2/NF-κB signaling pathway.
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Neurotrophic factors BDNF and GDNF protect dopaminergic neurons in PD mice by preventing neuronal death.
“Neurotrophic factors, such as BDNF and GDNF, have been shown to protect dopaminergic neurons in PD mice by preventing neuronal death [31,32].”
From Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson’s Disease (2022) · cites this paper as [31]
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References 29 · Cited by 41
- Authors
- Yan, T., Mao, Q., Zhang, X., Wu, B., Bi, K., He, B., & Jia, Y.
- Affiliations
- Shenyang Pharmaceutical University (CN)
- Corresponding author
- Jia, Ying
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 12
- Issue
- 9
- Pages
- 4079-4091
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W3137582756
- Cited by
- 41
- References
- 29
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 10 · 2023: 6 · 2022: 7 · 2021: 1
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Postdoctoral Science Foundation (2020M681518)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant-derived Lignans Synthesis and Bioactivity
- Keywords
- Schisandra chinensis, Parkinson's disease, 6-hydroxydopamine, neuroprotection, oxidative stress, neuroinflammation, apoptosis, brain-derived neurotrophic factor, Nrf2, NF-κB, GSK3β, reactive oxygen species, superoxide dismutase, inflammatory cytokines, caspase-3, caspase-9, p53
- MeSH terms
- Animals, Corpus Striatum, Disease Models, Animal, Dopamine, Drugs, Chinese Herbal, Hippocampus, Phytotherapy, Mice, Inbred C57BL, Signal Transduction, Cytokines, NF-kappa B, Oxidopamine, Apoptosis, Oxidative Stress, Neuroprotective Agents, Brain-Derived Neurotrophic Factor, Parkinsonian Disorders, Schisandra, NF-E2-Related Factor 2, Mice, Dopaminergic Neurons
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