Exosome-mediated delivery of gene vectors for gene therapy
Open accessAbstract
Exosome encapsulation protects and delivers AAV vectors for gene therapy.
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Two main approaches can be used to enhance targeting ability of exosomes: direct chemical modification or indirect genetic engineering.
“Two main approaches can be used to enhance the targeting ability of exosomes for specific applications: direct modification of exosomes by chemical means or, indirect manipulation of the donor cells through genetic engineering techniques [89, 103, 118–120]”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [89]
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References 74 · Cited by 238
- Authors
- Duan, L., Xu, L., Xu, X., Qin, Z., Zhou, X., Xiao, Y., Liang, Y., & Xia, J.
- Affiliations
- Shenzhen University Health Science Center (CN)
- Queensland University of Technology (AU)
- Shenzhen KangNing Hospital (CN)
- Chinese University of Hong Kong (HK)
- Corresponding author
- Liang, Yujie
- Xia, Jiang
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 13
- Issue
- 3
- Pages
- 1387-1397
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W3112346014
- Cited by
- 238
- References
- 74
- Citations by year
- 2026: 15 · 2025: 41 · 2024: 42 · 2023: 69 · 2022: 54 · 2021: 16 · 2012: 1
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion, other-oa)
- Funders
- National Natural Science Foundation of China (81772394, 81972116)
- Natural Science Foundation of Guangdong Province (2018B0303110003, 2020A1515011581)
- Shenzhen Science and Technology Innovation Program (KQTD20170331100838136, JCYJ20180306170922163, JCYJ20200109150700942, JCYJ20170413161649437, JCYJ20170817172023838)
- Chinese University of Hong Kong
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, gene delivery vectors, gene therapy, nucleic acid carriers, exosome engineering, targeted delivery
- MeSH terms
- Genetic Vectors, Liposomes, Genetic Therapy, Drug Delivery Systems, Exosomes
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