Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation
Abstract
Postulated mechanisms of lifespan extension by EGT: preservation of CNS via the coordination of cholinergic neurotransmission, tyrosine metabolism, and peroxisomal proteins, regulated autophagic activity, and preservation of mitochondrial function.
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Treatment with ergothioneine stabilizes the content of glutathione in the brain of aging flies.
“Treatment with ergothioneine stabilizes the content of glutathione in the brain of aging flies (Pan et al. 2022).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Pan et al. 2022
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References 53 · Cited by 34
- Authors
- Pan, H.-Y., Ye, Z.-W., Zheng, Q.-W., Yun, F., Tu, M.-Z., Hong, W.-G., Chen, B.-X., Guo, L.-Q., & Lin, J.-F.
- Affiliations
- College of Food Science & Institute of Food Biotechnology, South China Agricultural University, Guangzhou 510640, China
- Guangzhou Alchemy Biotechnology Co., Guangzhou 510760, China
- South China Agricultural University (CN)
- Corresponding author
- Guo, Li-Qiong
- Lin, Jun-Fang
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 13
- Issue
- 1
- Pages
- 227-241
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W3215200648
- Cited by
- 34
- References
- 53
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 4 · 2023: 6 · 2022: 4
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31772373, 32072646, 32001832, 31901693, 31801918)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- ergothioneine, Drosophila melanogaster, cholinergic neurotransmission, tyrosine metabolism, fatty acid oxidation, peroxisomes, autophagy, cathepsin D, lysosomes, mitochondrial function, TCA cycle, dietary supplementation
- MeSH terms
- Animals, Antioxidants, Drosophila melanogaster, Ergothioneine, Fatty Acids, Female, Longevity, Male, Tyrosine, Oxidative Stress, Cholinergic Agents, Glutathione Disulfide
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