Cell-derived extracellular vesicles for CRISPR/Cas9 delivery: engineering strategies for cargo packaging and loading
Abstract
This review summarizes the use of cell-derived vesicles, including EVs and exosomes for the delivery of CRISPR/Cas tools, with a focus on the state-of-the-art engineering strategies to realize efficient cargo packaging and loading.
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Exosomes can be genetically engineered, chemically surface modified or enzymatically engineered to introduce peptides and proteins to enhance their targeting ability.
“In addition, exosomes can be genetically engineered, chemically surface modified or enzymatically engineered to introduce peptides and proteins to enhance their targeting ability [42, 83–86].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [42]
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References 62 · Cited by 72
- Authors
- Liang, Y., Iqbal, Z., Wang, J., Xu, L., Xu, X., Ouyang, K., Zhang, H., Lu, J., Duan, L., & Xia, J.
- Affiliations
- Shenzhen KangNing Hospital (CN)
- Shenzhen University (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Chinese University of Hong Kong (HK)
- Corresponding author
- Lu, Jianping
- Duan, Li
- Xia, Jiang
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 10
- Issue
- 15
- Pages
- 4095-4106
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W4283734806
- Cited by
- 72
- References
- 62
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 20 · 2023: 25 · 2022: 3
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20200109150700942, SGDX20201103095800003, GJHZ20200731095606019)
- Basic and Applied Basic Research Foundation of Guangdong Province (2020A1515011581, 2021A1515010985)
- Special Project for Research and Development in Key areas of Guangdong Province (2019B030335001)
- Sanming Project of Medicine in Shenzhen (SZSM201612079)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- extracellular vesicles, CRISPR/Cas9 delivery, genome editing, single guide RNA, cargo packaging, vesicle engineering, vesicle biogenesis, vesicle trafficking, non-viral gene delivery, nanotherapeutics, gene therapy
- MeSH terms
- Extracellular Vesicles, Gene Editing, Genetic Therapy, RNA, Small Untranslated, CRISPR-Cas Systems
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