Chasing molecular glue degraders: screening approaches
Domostegui, Ana, Nieto-Barrado, Luis, Perez-Lopez, Carles, Mayor-Ruiz, Cristina·2022·Chemical Society Reviews
Cited by (200)
Items 101–200 of 200
- Recent Advances in Targeted Protein Degradation Molecular Glues as Anticancer DrugsYulin Shen, Wen Wen, L Chen, Nan Zhang, Cong Wei, Honggang Hu · 2025 · Clinical and Experimental Pharmacology and Physiology
- Nanoparticle-mediated targeted protein degradation (NanoTPD): Principles, rational design and mechanisms of degradationYunting Zhang, Keran Wang, Yixiang Yang, Tao Gong, Zhirong Zhang, Renhe Liu, Yao Shi Fu · 2025 · Nano Today
- Design, synthesis and biological evaluation of novel quinazolinone derivatives as CRBN E3 ligase modulatorsLinyi Liu, Renhong Sun, Haixia Liu, Chaowei Ren, Yuedong Zhou, Xing Qiu, Ying Kong, Biao Jiang, Xiaobao Yang · 2022 · European Journal of Medicinal Chemistry
- Development of a nano-targeting chimera for the degradation of membrane and cytoplasmic proteinsPeipei Jin, Zhaozheng Chen, Ju Zhang, Haowen Li, Pengfei Wei, Ziyu Wang, Qiyu Feng, Hongyang Wang, Da Han, Yanyan Miao · 2025 · Acta Biomaterialia
- Strengths, Weaknesses, Opportunities, and Potential Threat Analysis of Targeting Leucine-Rich Repeat Kinase 2 for Parkinson’s Disease Treatment: Status Quo and Quo VadisChenyu Dang, Zifan Feng, Tao Xu, Mi Li, Zhipeng Wang, H. L. Song, Rubing Wang · 2025 · Journal of Medicinal Chemistry
- Restoring adapter protein complex 4 function with small molecules: an in silico approach to spastic paraplegia 50Serena Francisco, Lorenzo Lamacchia, Attilio Turco, Giuseppe Ermondi, Giulia Caron, Matteo Rossi Sebastiano · 2024 · Protein Science
- Rewiring tumor immunity via zinc finger proteins: a new frontier in cancer immunotherapyZimu Zhou, Wu Le, Jun‐Li Luo, Zhijun Li, Shangwei Zhong · 2025 · Journal of Translational Medicine
- Expanding the druggable proteome strategies and innovations in targeted protein degradationKe Ma, Ting Liu, Wen-Bo Huan, Ke-Zheng Chen, Sheng‐Lin Qiao · 2025 · Nano Today
- A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue DegradersYifan Zhang, Linlin Li, Jiayi Xu, Chun-Chen Che, Jiaqing Jia, Haohao Lu, Qidong You, Xiaoli Xu · 2026 · Molecules
- Rational engineering of degradation tail-driven CELMoD–antibody conjugates for precision malignancy therapyYu Lian Guo, Yi Song, Hanlin Wang, Lu Yang, Jingyu Zhang, Zheyuan Shen, Weijuan Kan, Yuxian Wang, Haiting Duan, Shuangshuang Geng et al. · 2025 · Acta Pharmaceutica Sinica B
- Chemical rewiring of ubiquitination by degraders and their selectivity routesRory Whelan, Cristina Mayor‐Ruiz · 2024 · Nature Structural & Molecular Biology
- The antitumor peptide M1-20 induced the degradation of CDK1 through CUL4-DDB1-DCAF1-involved ubiquitinationHuitong Bu, Chaozhu Pei, Min Ouyang, Yan Chen, Yu Li, Xiaoqin Huang, Yongjun Tan · 2024 · Cancer Gene Therapy
- Kinase-Bench: Comprehensive Benchmarking Tools and Guidance for Achieving Selectivity in Kinase Drug DiscoveryTian‐Hua Wei, Shuangshuang Zhou, Xiaolong Jing, Jia‐Chuan Liu, Meng Sun, Zong-Hao Zhao, Qingqing Li, Zixuan Wang, Jin Yang, Yun Zhou et al. · 2024 · Journal of Chemical Information and Modeling
- Toward In Silico Design of Protein–Protein Interaction StabilizersJintao Zhu, Luhua Lai, Jianfeng Pei · 2023 · ACS Central Science
- Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of conceptScott J. Hughes, Wojciech J. Stec, Colin T. R. Davies, David J. McGarry, Alicia Williams, Iván del Barco Barrantes, Rebecca Harris, Dominic D. G. Owens, Alexander Fawcett, John Hellicar et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Comparative assessment of co-folding methods for molecular glue ternary structure predictionYiyan Liao, Jintao Zhu, Juan Xie, Luhua Lai, Jianfeng Pei · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Targeted protein degradation: therapeutic potential and challenges of PROTACs and molecular gluesSun Kim, Eui‐Bae Jeung · 2025 · Journal of Biomedical Translational Research
- USP5 deubiquitylates and stabilizes FcεRIγ to enhance IgE-induced mast cell activation and allergic inflammationZi-Wen Zhou, Xue-Ting Xu, Qiu-Ni Liang, Yan-Mei Zhou, Wan-Zhen Hu, Shan Liu, Yu-Xin Jiao, S C Zhang, Kunmei Ji, Jiajie Chen · 2025 · Science Signaling
- Targeted protein degradation of HSP90 and associated proteins for cancer therapy via PROTACs and beyondGulshan Kumar, Gouri Tyagi, Vikramdeep Monga · 2025 · RSC Medicinal Chemistry
- Clues for glues: from serendipity to nature’s blueprints in degrader discoveryZuzanna Kozicka · 2025 · Essays in Biochemistry
- Molecular glue degraders: Rational design, specificity engineering, and advanced deliveryLieen Ma, Ning Wang, Jingjing Zhu, Lingjie Wu, Shan He, Bin Zhang · 2026 · Acta Pharmaceutica Sinica B
- Tumor microenvironment activatable immunomodulator for cancer immunotherapyWeiqi Wang, Xingxing Liu, Zijiao Yan, Ke Yan, Mengjiao Zhou, Yumin Yang, Haijun Yu · 2026 · Journal of Controlled Release
- Advantages of PROTACs in achieving selective degradation of homologous protein familiesLuxi Yang, Xinfei Mao, Jingyi Zhang, Jing Shu, Wenhai Huang, Xiaowu Dong, Yinqiao Chen, Mingfei Wu · 2026 · Beilstein Journal of Organic Chemistry
- Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD)Mainak Banerjee, Alexandre Detappe, Twan Lammers · 2026 · Advanced Drug Delivery Reviews
- Pan-cancer proteogenomic interrogation of the ubiquitin-proteasome systemTania J González-Robles, Maha Khan, Paul Sastourne-Haletou, Marisa Triola, Hua Zhou, Yuki Kito, Sharon Kaisari, David Fenyö, Gergely Róna, Yadira M. Soto‐Feliciano et al. · 2026 · Cell Death and Differentiation
- Valorization of residual lignin from corncob residues into thermosensitive lignin-based “molecular glues” for recycling cellulaseJinxian Shan, Feiyun Li, Hongming Lou, Yanjun Tang · 2024 · International Journal of Biological Macromolecules
- Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to DegradersBárbara M. G. Barbosa, Aikaterini Sfyaki, Sergi Rafael, Ferran José‐Duran, Joan Pous, Carolina Sánchez, Carles Perez‐Lopez, Mar Vilanova, Marko Cigler, Marina Gay et al. · 2023 · Angewandte Chemie International Edition
- Native mass spectrometry for proximity-inducing compounds: a new opportunity for studying chemical-induced protein modulationEmanuele Fabbrizi, Francesco Fiorentino, Fabrizio Casano, Antonello Mai, Dante Rotili · 2025 · Expert Opinion on Drug Discovery
- PhenoDEL as a Novel Screening Strategy Based on Intracellular Protein Degradation ActivityYuichi Onda, Yurika Ochi, Toshihiro Araki, Miho Kageoka, Shuzo Takeda, Kazunori D. Yamada, Takehiko Ueda, K. Ohno, M. Tanaka, Daiki Sakai et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Optimization and Evaluation of Complementary Degrader Discovery Assays for Application in ScreeningJohanna Huchting, Arjen Weller, Moyra Schweizer, Mona Brandt, Jan Heering, Maria Kuzikov, Markus Wolf, Jeanette Reinshagen, Markus A. Queisser, Philip M. Gribbon et al. · 2025 · ACS Pharmacology & Translational Science
- Mapping the global landscape of molecular glues in drug discovery: a bibliometric analysis from 2010 to 2024Sonali Labhade, Ritesh P. Bhole, Pawan N. Karwa, Harshad S. Kapare, Subhashini Singh · 2025 · Naunyn-Schmiedeberg s Archives of Pharmacology
- Molecular glues and PROTACs: unlocking targeted protein degradation in plant biologyCarla Donderis-Fagoaga, Lidia Orea-Ordóñez, Jorge Lozano‐Juste · 2026 · Journal of Experimental Botany
- Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to DegradersBárbara M. G. Barbosa, Aikaterini Sfyaki, Sergi Rafael, Ferran José‐Duran, Joan Pous, Carolina Sánchez, Carles Perez‐Lopez, Mar Vilanova, Marko Cigler, Marina Gay et al. · 2023 · Angewandte Chemie
- Research advancements in molecular glues derived from natural product scaffolds: Chemistry, targets, and molecular mechanismsLina Yin, Tingting Niu, Ling Li, Wei Dong Yu, Bo Han, Asma Rehman, Ke‐Wu Zeng · 2025 · Chinese Herbal Medicines
- An in-silico approach for novel molecular glue design by rationalizing known molecular glue mediated ternary complex formationBen Geoffrey A S, Nagaraj M. Kulkarni, Deepak Agrawal, Nivedita Bharti, Rajappan Vetrivel, Kishan Gurram · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- ZNF276 and WIZ are CRBN neosubstrates involved in the anti-angiogenic activity of thalidomide and immunomodulatory drugsTakumi Ito, Tomoko Asatsuma‐Okumura, Akinori Endo, Junichi Yamamoto, Yoshiko Iwai, Yuki Yamaguchi, Mikihiko Naito, Hiroshi Handa, Yasushi Saeki · 2023 · Research Square
- Molecular Degraders: A Comprehensive Review of Small Molecule Induced Protein Degradation StrategiesDeepanshu Sindhwani, Kaushal Arora, Pankaj kumar, Prabhakar Kumar Verma, Vivek Vidyadhar Bhosale · 2025 · Current Protein and Peptide Science
- Chemical and genetic molecular glues to degrade CoREST corepressorsYingqi Song, Qingjun Li, Chunquan Sheng · 2025 · Acta Pharmaceutica Sinica B
- Degraders of cell cycle- and antiapoptosis-related proteinsYingqiong Zhang, Rong Dong, Bo Zhang · 2025 · Elsevier eBooks
- Discovery of fluorescent theranostic molecular glues for real-time visualization and target degradation toward eEF2KTingting Liu, Jie Ma, Gaopan Dong, Mei Zhang, Subin Song, Xuerui Zhang, Shixiang Qi, Mingyu Cheng, Wenjie Liu, Xu Wang et al. · 2025 · European Journal of Medicinal Chemistry
- Microproteins: novel multi-functional regulators in health and diseaseJia‐Peng He, Haozhe Zhang, Bin Liao, Qianyu Xu, Jeremy Yuen‐Chun Teoh, Chi‐Fai Ng, Dinglan Wu, Xian-Tao Zeng, Chris Soon Heng Tan, Hailiang Hu · 2025 · Oral Science and Homeostatic Medicine
- A DRUG HUNTER’S APPROACH TO MOLECULAR GLUESDaniel S. La, Christopher G. Nasveschuk, Adam M. Gilbert · 2025 · Medicinal chemistry reviews
- Computational approaches enhance the design of molecular glue degraders for undruggable proteinsSirishantha G M A Deshani, Gunarathna R D S Madushani, Veranja Karunaratne, Kumar Vinit, Ge‐Fei Hao · 2025 · Drug Discovery Today
- An Integrated Approach Combining Surface Plasmon Resonance Screening with Proteomics Enables Discovery of Natural Molecular Glue DegradersYueying Yang, Rui Zhu, Jing Liang, Hongwei Yan, Huadong Zhang, Jundan Tian, Rui Zhang, Xiaofen Liu, Ying Liu, Hua Li et al. · 2026 · JACS Au
- Therapeutic targeting of CDK12: a medicinal chemistry perspectiveFeifei Wang, Hongxue Dai, Kuanxin Wan, Mingliang Wang · 2026 · Bioorganic & Medicinal Chemistry
- Synthetic and Medicinal Chemistry Perspectives on Cereblon‐Binding Molecular Glue Degraders: Recent Advances and Emerging TrendsHyuck-Jae Won, Seung Mok Baek, Min Hoo Lee, Jae Hyeon Park, Jeong‐Won Shin, Yo‐Sep Yang, Yoon Hu Jang, Kyung‐Soo Inn, Nam‐Jung Kim · 2026 · European Journal of Organic Chemistry
- Covalent Inhibitors of Monoacylglycerol Lipase Induce Conformational Changes and Proteasomal DegradationJordan A. Pham, Thanawat Thaingtamtanha, William McLeish, David Lefebvre, Spencer M. Uguccioni, Roxana Filip, Francesco Gentile, John Paul Pezacki · 2026 · Journal of the American Chemical Society
- A Scalable, Direct‐to‐Biology Platform for Accelerated Discovery of Cereblon‐Based Molecular Glue DegradersJia‐Yu Wang, Guang‐Liang Yin, Yijia Chi, Yuan‐Peng Feng, Chu‐Cheng Zhou, Hui‐Jun Nie, Zhi‐Gao Zhang, Shuting Meng, Yang Chen, Zhi‐Peng Zhou et al. · 2026 · Angewandte Chemie International Edition
- Selective CDK2 Degradation via Noncanonical RecruitmentYuanyuan Pei, Weiye Lin, Xinzhu Li, Yuhang Meng, Yuling Yin, Benxun Pan, Lixin Zhou, Linhui Cao, Yong Cang, Yi Jiang et al. · 2026 · Journal of Medicinal Chemistry
- UbiDash: A UPS proteomic atlas for tissue-aware degrader designTania J González-Robles, Paul Sastourne-Haletou, Marisa Triola, Maha Khan, Áron Bartha, Jeffrey Estrada, Yadira M. Soto‐Feliciano, Benjamin G. Neel, David Fenyö, Michele Pagano et al. · 2026 · Cell Death and Differentiation
- The synthetic landscape of cereblon (CRBN) binders: from thalidomide to emerging chemotypesSergi Rafael, Carolina Sánchez, Rory Whelan, Clifford Harris, Xavier Verdaguer, Cristina Mayor‐Ruiz, Antoni Riéra · 2026 · Chemical Society Reviews
- From nature to synthetic analogues: recent advances in the design and synthesis of natural product-based librariesIván Cheng‐Sánchez, Irama Fuentes-Pino, Mohamed El Hllafi, Federico Moya‐Utrera, Juan Manuel López‐Romero, Amelia Díaz, Antonio Sánchez‐Ruiz, Michio Kurosu, Francisco Sarabia · 2026 · Organic Chemistry Frontiers
- Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospectsShuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo et al. · 2026 · Smart Molecules
- Berberine, a natural molecular glue degrader, overcomes CML resistance via TRIM28-mediated HIF1α ubiquitination and subsequent ferroptosisRui Su, Rongjun Xu, Wenjing Shi, Wenjing Song, Xingri Zhan, Yiling Long, Xiuyuan Wang, Hong Nie, Jia Fei · 2026 · Cell Reports
- Ubiquitin receptor–mediated, ubiquitin-independent targeted protein degradation via 26 S proteasomesSeh Hoon Park, Yejin Jang, Soo-Yeon Lee, Eunseo Kim, Dawon Jeong, Insuk Byun, Jiseong Kim, Jisoo Yang, Chang‐Han Lee, Dohyun Han et al. · 2026 · Science Advances
- Molecular glue degraders enhance CAPRIN1-dependent lysosomal degradation of APP in Alzheimer’s diseaseSung Han Jung, Raktim N. Roy, Xu Wang, Bin Liu, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Li‐Fan Zeng, Ho-Yin Lo et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Targeted KRAS G12V degradation elicits efficient and durable lung adenocarcinoma regression in vivoAlberto J. M. Martín, Inés M. García-Pérez, Sonia San José, Pep Rojo, Carlos Riego‐Mejías, Cristina Teodósio, Bárbara M. G. Barbosa, Carolina Sánchez, Ignasi Folch-I-Casanovas, Antonia Odena Caballol et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- P53 upregulation by USP7-engaging molecular gluesBoxun Lu, Zhaoyang Li, Ziying Wang, Ping An, Hang Zhang, Chao Zhong, Rui Liu, Z. Ma, Junmei Lü, Chengfang Pan et al. · 2023 · Research Square
- Research progress in small-molecule modulators of protein-protein interactionsBin Yang, Xiangbing Qi · 2023 · Chinese Science Bulletin (Chinese Version)
- Unveiling Innovative anti-influenza Agents Through Modern Medicinal Chemistry Approaches (2019–2023 updates)Chuanfeng Liu, Lide Hu, Huinan Jia, Jiwei Zhang, Guanyu Dong, Edeildo Ferreira da Silva‐Júnior, Xinyong Liu, Peng Zhan · 2023 · Future Medicinal Chemistry
- Pre‐mRNA Splicing ModulationScott J. Barraza, Matthew G. Woll · 2024 · Methods and principles in medicinal chemistry
- Palbociclib, ribociclib, and abemaciclib: potent and selective CDK4/6 inhibitors for the treatment of breast cancerKai Yuan, Weijiao Chen, Xiao Wang, Peng Yang · 2024 · Elsevier eBooks
- A Comprehensive Overview of Protacs Targeting Hsp90 and Their Client Proteins for Cancer TherapyGulshan Kumar, Gouri Tyagi, Vikramdeep Monga · 2025 · SSRN Electronic Journal
- Targeted Protein Degradation of MetalloenzymesConor O’Herin, Seth M. Cohen · 2025 · Wiley eBooks
- Molecular Glues as Activators for PPIXiangbing Qi · 2025 · Wiley eBooks
- Nucleic acid-encoded antibody gene transfer-next generation of antibody therapiesKaikai Yu, Geng Xiao, Baichuan Chen, Na Xu, Wensen Liu · 2025 · Drug Delivery
- Progress on molecular glue degradersJiaqi Chen, Zhiheng Deng, Haoxiang Li, Lei Liu · 2025 · Scientia Sinica Chimica
- Degradation of Cyclin-Dependent Kinase: A New Weapon for Cancer TherapyXing Tian, Xiaojie Dai, Ye Zhong, Maosheng Cheng, Yang Liu · 2025 · Pharmaceutical Fronts
- A CK2-FBXW11 kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating Tryptophan 2,3-dioxygenase stabilityAlina S. Thielen, Bastian Bräuning, Karthik V Gottemukkala, Judith Müller, Jesuraj Rajan Prabu, Simon Klaessens, Benoit J. Van den Eynde, Peter J. Murray, Brenda Arlene Schulman · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic ApplicationsJiaye Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang · 2026 · MedComm – Oncology
- Indazolone-Based Molecular Glue Degraders as a Tunable Platform for Reprogramming Cereblon Substrate SpecificityHui‐Jun Nie, Jiamin Wang, Hao Xu, Yin-Jue Zhou, Guang‐Liang Yin, Xiaomim Xu, Gaoya Xu, Beijing Chen, Xian Li, Xiaobei Hu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Molecular Glues for Undruggable Targets: Mechanisms, Clinical Applications, and AI-driven DesignZike Chen, W. C. S. Meng, Mengyan Chen, Chen Wang, Min Shi · 2026 · Current Drug Targets
- A Live-Cell Analytical Platform by Using Strigolactones-Induced Dimerization SystemKun Zang, Xinwei Lu, Chaoliang Diao, Chaoqing Dong, Jicun Ren · 2026 · Analytical Chemistry
- The degradation revolution: harnessing targeted protein degradation for the treatment of human diseasesJie Tong, Peng Wang, Saiya Ma, Jing Li, Yufei Zhan, Mengxuan Liu, Feng Jin, Guosheng Qu, Chunfu Zheng, Xiaochun Wang et al. · 2026 · Cellular and Molecular Life Sciences
- Harnessing Targeted Protein Degradation for Developing Brain Cancer TherapyOsaid Muhammad, Sophie White, Carina Jungha Dumo, Thomas I‐H. Park, Peter J. Choi, Jiney Jose · 2026 · Bioconjugate Chemistry
- Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 DegradationTaowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, 黄康柏, Zhu Wang, Qiong Deng et al. · 2026 · Advanced Science
- Targeted protein degradation in the digital era: Computational challenges and opportunities for PROTACsAishani Tewari, Aiswarya B. Pawar, Sudip Roy · 2026 · In Silico Research in Biomedicine
- A Scalable, Direct‐to‐Biology Platform for Accelerated Discovery of Cereblon‐Based Molecular Glue DegradersJia‐Yu Wang, Guang‐Liang Yin, Yijia Chi, Yuan‐Peng Feng, Chu‐Cheng Zhou, Hui‐Jun Nie, Zhi‐Gao Zhang, Shuting Meng, Yang Chen, Zhi‐Peng Zhou et al. · 2026 · Angewandte Chemie
- The Novel Compound SIC-19 Triggers CUL4B-Mediated Ubiquitination and Degradation of SIK2Yeqiu Zou, Jiaqi Liu, Shunpeng Zhu, Qi Li, Qi Li, Fang Wang, Youguo Chen, J Zhou · 2026 · Molecular and Cellular Biology
- Discovery of CRBN ‐based molecular glue degraders targeting WIZ transcription factorTaejun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jae‐Joong Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi · 2026 · Bulletin of the Korean Chemical Society
- Design, Synthesis, and Biological Evaluation of a MyD88-Targeted Molecular Glue d21 for the Treatment of Acute Lung InjuryLuxiao Zhu, Dan Tang, Ting Chen, Chenhui Sun, Ke Dong, Q W Chen, 戴勤学, 莫云长, Pan Chen, Jinfeng Sun et al. · 2026 · Journal of Medicinal Chemistry
- Small-molecule-mediated RNA targeting: emerging strategies and therapeutic potential of RiboTACWei Zhou, 金锦梅, Ye Wu, 陈红专, Weidong Zhang, Xin Luan · 2026 · Targetome
- Mapping Scientific Landscapes and Therapeutic Innovations of Targeted Protein Degradation: A Scientometric ReviewChong Li, Xiangxiu Wang, He A, Tianjie Bao, Weihua Zhuang, Chengqi He, Yonghong Yang · 2026 · Pharmaceutics
- Nanotechnology‐Enabled Targeted Protein Degradation: Strategies, Opportunities, and ChallengesHaoran Zhu, Yijun Zhang, Yuhua Ning, Chaoyong James Yang, Guihua Zhang, Zhi Zhu · 2026 · Small Methods
- PhenoDEL: A Novel Screening Strategy Based on Intracellular Protein Degradation ActivityYuichi Onda, Yukio Ochi, Toshihiro Araki, Miho Kageoka, Shuzo Takeda, Kazunori Yamada, Takehiko Ueda, Ken Ohno, M. Tanaka, Daiki Sakai et al. · 2026 · ACS Chemical Biology
- Supramolecular Degraders: An Emerging Paradigm in Targeted Protein DegradationKongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Xia Chen, Peiyi Wang, Jian-Mei Gao, Qihai Gong · 2026 · Advanced Science
- Peptide-Based Molecular Glues for Targeted Protein DegradationWalaa S. Aburayan, Ibrahim A. Alradwan, Beshair Alsaffar, Othman A. Alhazzaa, Fahad A. Almughem, Abdullah Awad Alshehri, Ibtihal S. Alduhaymi, Mohannad Fallatah, Meshael Alturki, Hassa A. Alshaya et al. · 2026 · Pharmaceutics
- A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of ProximityBingqi Tong, Sunny A. Tang, Yifan Deng, Zhihan Nan, Alison X. Gao, Gregory A. Michaud, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Shuang Liu et al. · 2026 · Advanced Science
- Iterative Optimization of Photoactivatable BRD4 Degraders for Aging‐Amplified Immunotherapy in Patient‐Derived Lung Cancer OrganoidsJinrong Yang, Fa Wang, Shufei Li, Kai Xiong, Taihong Liu, Yu Chen, Hui Chao · 2026 · Angewandte Chemie
- Iterative Optimization of Photoactivatable BRD4 Degraders for Aging‐Amplified Immunotherapy in Patient‐Derived Lung Cancer OrganoidsJinrong Yang, Fa Wang, Shufei Li, Kai Xiong, Taihong Liu, Yu Chen, Hui Chao · 2026 · Angewandte Chemie International Edition
- Recent Advances in Nanotechnology for Targeted Protein DegradationMengchen Xu, Yi Yang, Jiajing Chen, Xi Wang, Shuyu Wang, Feihe Ma, Linqi Shi · 2026 · ACS Applied Materials & Interfaces
- A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stabilityAlina S. Thielen, Bastian Bräuning, Karthik V Gottemukkala, Judith Müller, Jesuraj Rajan Prabu, Pooja Verma, Simon Klaessens, Benoı̂t J. Van den Eynde, Gary Kleiger, Peter J. Murray et al. · 2026 · Molecular Cell
- The ternary complex structure as a foundation for structure-guided molecular glue designAngus D. Cowan · 2026 · Essays in Biochemistry
- From Ubiquitination to Proteasome-Directed Recruiting: Emerging Mechanisms and Therapeutic Potential in Targeted Protein DegradationYaoli Shi, Jiayi Ma, Yutong Tu, Qingyi Wang, Mingzhi Wang, Jiaan Shao, Guifeng Wang, Jia Li, Huajian Zhu, Yubo Zhou et al. · 2026 · Journal of Medicinal Chemistry
- BindingDB Entry 50021951: Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50020994: Facilitating the development of molecular glues: Opportunities from serendipity and rational design.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50023421: TBABindingDB · 2026 · UC San Diego
- BindingDB Entry 50023632: Small-Molecule Modulators Targeting Coactivator-Associated Arginine Methyltransferase 1 (CARM1) as Therapeutic Agents for Cancer Treatment: Current Medicinal Chemistry Insights and Emerging Opportunities.BindingDB · 2026 · UC San Diego
- BindingDB Entry 50021128: Small molecules targeting selected histone methyltransferases (HMTs) for cancer treatment: Current progress and novel strategies.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50021378: Electrophile Determines Cellular Phenotypes among XPO1-Targeting Small Molecules.BindingDB · 2025 · UC San Diego