The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Bicyclobutanes: from curiosities to versatile reagents and covalent warheads
Open accessAbstract
A flurry of reports for preparing, functionalizing, and using bicyclo[1.1.0]butanes (BCBs) have positioned them to be powerful synthons with numerous applications. This review discusses the recent developments regarding this strained carbocycle.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
Lovering, F., Bikker, J., & Humblet, C. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm901241e · Cited by 4,495
Escape from Flatland 2: complexity and promiscuity
Lovering, F. (2013) · MedChemComm · doi:10.1039/c2md20347b · Cited by 1,444
Recent Advances in the Synthesis of Cyclobutanes by Olefin [2 + 2] Photocycloaddition Reactions
Poplata, S., Tröster, A., Zou, Y.-Q., & Bach, T. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00723 · Cited by 1,127
The Concept of Strain in Organic Chemistry
Wiberg, K. B. (1986) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198603121 · Cited by 745
Gehringer, M., & Laufer, S. A. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01153 · Cited by 714
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design
Subbaiah, M. A. M., & Meanwell, N. A. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01215 · Cited by 710
Saturated bioisosteres of benzene: where to go next?
Mykhailiuk, P. K. (2019) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob02812e · Cited by 613
Matsui, J. K., Lang, S. B., Heitz, D. R., & Molander, G. A. (2017) · ACS Catalysis · doi:10.1021/acscatal.7b00094 · Cited by 592
Put a ring on it: application of small aliphatic rings in medicinal chemistry
Bauer, M. R., Di Fruscia, P., Lucas, S. C. C., Michaelides, I. N., Nelson, J. E., Storer, R. I., & Whitehurst, B. C. (2021) · RSC Medicinal Chemistry · doi:10.1039/d0md00370k · Cited by 479
Stepan, A. F., Subramanyam, C., Efremov, I. V., Dutra, J. K., O’Sullivan, T. J., DiRico, K. J., McDonald, W. S., Won, A., Dorff, P. H., Nolan, C. E., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300094u · Cited by 468
Cited by
Bicyclobutanes as unusual building blocks for complexity generation in organic synthesis
Golfmann, M., & Walker, J. C. L. (2023) · Communications Chemistry · doi:10.1038/s42004-022-00811-3 · Cited by 313
Bellotti, P., & Glorius, F. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c08206 · Cited by 294
Alternating CO2 and bicycloalkane copolymerization to circular polyesters
Zhu, M., Westworth, X., Zhao, Y., Deshmukh, G. S., Barange, D. K., Zhang, T., Gowda, R. R., Broadbelt, L. J., & Chen, E. Y.-X. (2026) · Nature · doi:10.1038/s41586-026-10848-2 · Cited by 3
Metadata
- Authors
- Kelly, C. B., Milligan, J. A., Tilley, L. J., & Sodano, T. M.
- Venue
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 13
- Issue
- 40
- Pages
- 11721-11737
- ISSN
- 2041-6520 (ISSN-L)
- 2041-6539
- OpenAlex
- W4293091292
- Cited by
- 334
- References
- 36
- FWCI
- 22.20
- Type
- journal article
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bicyclobutanes: from curiosities to versatile reagents and covalent warheads. https://app.cochat.ai/papers/10.1039/d2sc03948f
- The paper
- Kelly, C. B., Milligan, J. A., Tilley, L. J., & Sodano, T. M. (2022). Bicyclobutanes: from curiosities to versatile reagents and covalent warheads. Chemical Science. https://doi.org/10.1039/d2sc03948f
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
