Standalone cell culture microfluidic device-based microphysiological system for automated cell observation and application in nephrotoxicity tests
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The SCCMD for MPS experiments, which integrates microfluidic chips and their peripherals, complies with the ANSI/SLAS standards and has been seamlessly integrated into an existing automatic cell imaging system for online cell observation.
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The double-layered microfluidic chip with a microporous membrane enables cell culture and controlled mass transport under perfusion conditions.
“The chip structure consists of top and bottom flow channels separated by a microporous membrane, enabling cell culture and controlled mass transport under perfusion conditions (Kimura et al., 2024).”
From Material-dependent oxygen transport governs ischemia-reperfusion injury and drug response in a kidney microphysiological system (2026) · cites this paper as Kimura et al., 2024
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Microfluidic titer plate for stratified 3D cell culture
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Cited by
Sorted by citations
Kutsuzawa, N., Nakamura, H., Shinha, K., & Kimura, H. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1854389
Self-citation
- Authors
- Kimura, H., Nakamura, H., Goto, T., Uchida, W., Uozumi, T., Nishizawa, D., Shinha, K., Sakagami, J., & Doi, K.
- Affiliations
- Tokai University (JP)
- Nikon (Japan) (JP)
- Institute of Industrial Science, The University of Tokyo (JP)
- Corresponding author
- Kimura, Hiroshi
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2024
- Volume
- 24
- Issue
- 3
- Pages
- 408-421
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W4390120448
- Cited by
- 20
- References
- 1
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 4
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Lab on a Chip (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development (JP20be0304204)
- Japan Society for the Promotion of Science (JP18H01849, JP21H02824)
- Tokai University
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Keywords
- microphysiological systems, perfusion culture, organ-on-a-chip
- MeSH terms
- Microphysiological Systems, Epithelial Cells, Humans, Cell Culture Techniques, Microfluidics, Lab-On-A-Chip Devices
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