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Cited by 47Electrochemical sensors and biosensorsAdvanced biosensing and bioanalysis techniquesElectrochemical Analysis and Applications

Nano-modified screen-printed electrode-based electrochemical immunosensors for oral cancer biomarker detection in undiluted human serum and saliva samples

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Gulati, Payal, Singh, Avinash Kumar, Yadav, Amit K., Pasbola, Kiran, Pandey, Prerna, Sharma, Rinu, Thakar, Alok, Solanki, Pratima R.·2024·Nanoscale Advances
DOI 10.1039/d3na00682dPMC PMC10791120
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Abstract

The schematic illustration of step wise fabrication of in-house-made screen-printed electrodes for simultaneous detection of multiple cancer biomarkers.

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  • The miR-21 sensing approach has been applied to salivary samples from 20 oral cancer patients, achieving a diagnostic sensitivity of 90% and a specificity of 85%.

    “This sensing approach has been successfully applied to salivary samples from 20 oral cancer patients, achieving a diagnostic sensitivity of 90% and a specificity of 85%.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [91]

    The Introduction (page unavailable) says the study tested 16 saliva samples, not 20, using immunosensors for CYFRA 21-1, IL-8, and TP-53 rather than miR-21. The Conclusion (page unavailable) reports no diagnostic sensitivity of 90% or specificity of 85%. (LLM, conf=0.88)

    Checked by a reasoning model — may be wrong.

    Experimental — accuracy not yet measured

  • PDA films adsorb FAM-labeled probes complementary to miR-21, resulting in a fluorescence quenching efficiency of 96%.

    “PDA films are first used to adsorb FAM-labeled probes complementary to miR-21, resulting in a fluorescence quenching efficiency of 96%.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [91]

    The Experimental procedure describes antibody-based electrochemical sensors for CYFRA 21-1, IL-8, and TP-53, not fluorescent miR-21 probes. Searches of our copy for PDA films, FAM-labeled probes, miR-21, and 96% quenching found no passage addressing the claim; no page number was provided for the indexed passages. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • The recovered fluorescence intensity exhibits a logarithmic linear relationship with miR-21 concentration over the range of 10 aM to 1 pM.

    “The recovered fluorescence intensity exhibits a logarithmic linear relationship with miR-21 concentration over the range of 10 aM to 1 pM.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [91]

    The Experimental procedure (Preparation of analyte(s) dilutions; page unavailable) describes cyclic-voltammetry measurements of protein biomarkers, and the Results and discussion (Electrochemical response studies; page unavailable) reports peak current versus CYFRA 21-1 concentration. Searches for miR-21, recovered fluorescence, and the 10 aM–1 pM range found no passage addressing the claimed relationship. (LLM, conf=0.77)

    Experimental — accuracy not yet measured

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References 47 · Cited by 47

Research works printed but not linked: 43

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Authors
Gulati, P., Singh, A. K., Yadav, A. K., Pasbola, K., Pandey, P., Sharma, R., Thakar, A., & Solanki, P. R.
Affiliations
  • Jawaharlal Nehru University (IN)
  • Guru Gobind Singh Indraprastha University (IN)
  • All India Institute of Medical Sciences (IN)
Corresponding author
Solanki, Pratima R.
ORCID
Venue
Nanoscale Advances
Publisher
Royal Society of Chemistry (RSC)
Published
2024
Volume
6
Issue
2
Pages
705-721
ISSN
2516-0230 (ISSN-L)
DOI
10.1039/d3na00682d
PMC
PMC10791120
OpenAlex
W4389194387
Cited by
47
References
47
Citations by year
2026: 12 · 2025: 24 · 2024: 11
FWCI
3.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Nanoscale Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Department of Science and Technology, Ministry of Science and Technology, India (TDP/49/2021)
  • Ministry of Education, India
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
Keywords
oral cancer, electrochemical immunosensor, screen-printed electrodes, saliva, serum, CYFRA21-1, interleukin-8, TP53, biomarker detection, label-free detection

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