Mn 2+ -induced structural flexibility enhances the entire catalytic cycle and the cleavage of mismatches in prokaryotic argonaute proteins
Open accessPublished version of a preprint
Abstract
Prokaryotic Argonaute (pAgo) proteins, a class of DNA/RNA-guided programmable endonucleases, have been extensively utilized in nucleic acid-based biosensors.
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Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
Metal ions in biological catalysis: from enzyme databases to general principles
Andreini, C., Bertini, I., Cavallaro, G., Holliday, G. L., & Thornton, J. M. (2008) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-008-0404-5 · Cited by 1,150 · see citing works
Hureau, C., & Faller, P. (2009) · Biochimie · doi:10.1016/j.biochi.2009.03.013 · Cited by 259 · see citing works
Flagged first, then by citations
- Authors
- Zheng, L., Zhou, B., Yang, Y., Zan, B., Zhong, B., Wu, B., Feng, Y., Liu, Q., & Hong, L.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhou, Bingxin
- Liu, Qian
- Hong, Liang
- ORCID
- Venue
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2024
- Volume
- 15
- Issue
- 15
- Pages
- 5612-5626
- ISSN
- 2041-6520 (ISSN-L)
- 2041-6539
- PMC
- PMC11023060
- OpenAlex
- W4392807531
- Cited by
- 11
- References
- 3
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 2
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Chemical Science (publishedVersion, cc-by-nc)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Shanghai Municipal Education Commission
- National Key Research and Development Program of China (2018YFA0900403)
- Shanghai Jiao Tong University (21TQ1400204)
- National Natural Science Foundation of China (62302291, 11974239, 22063007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- Argonaute proteins, prokaryotic Argonaute, manganese(II), structural flexibility, mismatch tolerance, RNA cleavage
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