Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha
Open accessPublished version of a preprint
Abstract
The single domain antibody, I3, interacts with fibroblast activation protein alpha through its CDR3 loop and FR2 region to bind a unique and previously undisclosed epitope that is distinct from the protease's active site.
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Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
Development of targeted alpha particle therapy for solid tumors.
Tafreshi, N. K., Doligalski, M. L., Tichacek, C. J., Pandya, D. N., Budzevich, M. M., El-Haddad, G., Khushalani, N. I., Moros, E. G., McLaughlin, M. L., Wadas, T. J., et al. (2019) · Molecules · doi:10.3390/molecules24234314 · Cited by 157 · see citing works
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- Authors
- Xu, Z., Sinha, A., Pandya, D. N., Schnicker, N. J., & Wadas, T. J.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Schnicker, Nicholas J.
- Wadas, Thaddeus J.
- Venue
- RSC Chemical Biology
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2025
- Volume
- 6
- Issue
- 5
- Pages
- 780-787
- ISSN
- 2633-0679 (ISSN-L)
- PMC
- PMC11834968
- OpenAlex
- W4407219915
- Cited by
- 5
- References
- 2
- Citations by year
- 2026: 3 · 2025: 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- RSC Chemical Biology (publishedVersion, cc-by-nc)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by-nc)
- Funders
- Congressionally Directed Medical Research Programs (W81XWH-19-1-0046)
- Division of Cancer Prevention, National Cancer Institute (P30CA086862, R21-CA219899, R21-CA227709)
- Topics
- Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Keywords
- fibroblast activation protein, nanobodies, antibody-antigen complex structure, binding epitope, serine protease, CDR3, protein dimer
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