Natural Deep Eutectic Solvents (NaDES): Green Solvents for Pharmaceutical Applications and Beyond
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This review first provides a comprehensive overview of NaDES theory and subsequently explores all potential applications of NaDES in the pharmaceutical industry, highlighting overlooked issues such as toxicity and process limitations.
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DESs are promising alternatives to traditional organic solvents in analytical chemistry because their tunable physicochemical properties enable selective and efficient extraction of a wide variety of analytes from diverse matrices.
“In this regard, deep eutectic solvents (DESs) have gained substantial attention as promising alternatives with the potential to reduce the environmental impact of extraction processes, depending on their chemical composition and intended application [13,14].”
From Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights (2026) · cites this paper as [14]
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References 137 · Cited by 156
- Authors
- Chevé-Kools, E., Choi, Y. H., Roullier, C., Ruprich-Robert, G., Grougnet, R., Chapeland-Leclerc, F., & Hollmann, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Leiden University (NL)
- Institut Des Substances et Organismes de la Mer (FR)
- Cibles Thérapeutiques et Conception de Médicaments (CiTCoM, UMR 8038 CNRS), Faculté de Pharmacie de Paris, Université Paris Cité, Paris, France
- Delft University of Technology (NL)
- Corresponding author
- Chevé-Kools, Emma
- ORCID
- Venue
- Green Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2025
- Volume
- 27
- Issue
- 28
- Pages
- 8360-8385
- ISSN
- 1463-9262 (ISSN-L)
- 1463-9270
- PMC
- PMC12062791
- OpenAlex
- W4409896167
- Cited by
- 156
- References
- 137
- Citations by year
- 2026: 126 · 2025: 30
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Green Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- Funders
- H2020 European Research Council (101054658)
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Environmental Science › Environmental Chemistry › Chemistry and Chemical Engineering
- Physical Sciences › Chemical Engineering › Filtration and Separation › Chemical and Physical Properties in Aqueous Solutions
- Keywords
- natural deep eutectic solvents, green solvents, pharmaceutical applications, drug synthesis, extraction, drug formulation, solubilization, non-covalent interactions, green metrics, toxicity, solvent recovery, nanotechnology, biotechnology
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