Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: in vitro and in silico studies
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A sequence of novel quinoline-1,3,4-oxadiazole hybrids has been synthesized and evaluated for their in vitro anti-proliferative and antimicrobial activities.
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References 83 · Cited by 13
- Authors
- Ryad, N., Elmaaty, A. A., Selim, S., Almuhayawi, M. S., Al Jaouni, S. K., Abdel-Aziz, M. S., Alqahtani, A. S., Zaki, I., & Abdel Ghany, L. M. A.
- Affiliations
- Misr University for Science and Technology (EG)
- Port Said University (EG)
- Jouf University (SA)
- King Abdulaziz University (SA)
- Department of Hematology/Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
- National Research Centre (EG)
- Imam Mohammad ibn Saud Islamic University (SA)
- Pharmaceutical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, P.O. Box 77, Giza, Egypt
- Corresponding author
- Selim, Samy
- Zaki, Islam
- ORCID
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2024
- Volume
- 14
- Issue
- 46
- Pages
- 34005-34026
- ISSN
- 2046-2069 (ISSN-L)
- PMC
- PMC11505673
- OpenAlex
- W4403763860
- Cited by
- 13
- References
- 83
- Citations by year
- 2026: 6 · 2025: 7
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- RSC Advances (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Structural and Chemical Analysis of Organic and Inorganic Compounds
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and Characterization of Heterocyclic Compounds
- Keywords
- 1,3,4-oxadiazole derivatives, quinoline derivatives, 4-bromophenyl, anticancer agents, antimicrobial agents, antibacterial activity, antifungal activity, structure-activity relationship, molecular docking, lead optimization
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