Studies on the hydrolysis of clavulanic acid
Abstract
1-Amino-4-hydroxybutan-2-one (14) has been identified as one of the major products from the hydrolysis of clavulanic acid in acidic, alkaline, or neutral solution. In alkaline or neutral solution, the amino ketone (14) is converted into other products, including two pyrazines, 2,5-bis(2-hydroxyethyl)pyrazine and 3-ethyl-2,5-bis(2-hydroxyethyl)pyrazine. A rationale for the formation of these products is discussed.
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The kinetic approach is consequent with a feasible chemical mechanism of reaction for CA in aqueous solutions characterized by several equilibrium steps.
“This kinetic approach is consequent with a feasible chemical mechanism of reaction for CA in aqueous solutions, characterized by several equilibrium steps (Figure 4) [28,29].”
From Degradation Kinetics of Clavulanic Acid in Fermentation Broths at Low Temperatures (2019) · cites this paper as [29]
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Degradation Kinetics of Clavulanic Acid in Fermentation Broths at Low Temperatures
Gómez-Ríos, D., Ramírez-Malule, H., Neubauer, P., Junne, S., & Ríos-Estepa, R. (2019) · Antibiotics · doi:10.3390/antibiotics8010006 · Cited by 17 · see citing works
- Authors
- Finn, M. J., Harris, M. A., Hunt, E., & Zomaya, I. I.
- Venue
- Journal of the Chemical Society, Perkin Transactions 1
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 1984
- Pages
- 1345
- ISSN
- 1364-5463 (ISSN-L)
- 0300-922X
- OpenAlex
- W2160354525
- Cited by
- 29
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Chemical Society Perkin Transactions 1 (publishedVersion)
- Funders
- University of Minnesota
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis of β-Lactam Compounds
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Synthetic Organic Chemistry
- Keywords
- clavulanic acid, hydrolysis, amino ketones, pyrazine, alkaline hydrolysis, acid hydrolysis, neutral hydrolysis, degradation products
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