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Peptide synthesis. Part 8. A system for solid-phase synthesis under low pressure continuous flow conditions
Abstract
Details are given of a novel technique for solid-phase peptide synthesis under continuous flow conditions. The resin support is a poly(dimethylacrylamide) gel polymerised within the pores of rigid macroporous kieselguhr particles. Manual and semiautomatic (microprocessor controlled) instrumentation is described for the use of this resin in synthesis. The method is illustrated by preparation of a pentadecapeptide sequence related to the repeating unit of adenovirus tail fibre. The value of continuous spectrometric monitoring of solid-phase synthesis is discussed.
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Citations
Cited by
Advances in Fmoc solid‐phase peptide synthesis
Behrendt, R., White, P., & Offer, J. (2016) · Journal of Peptide Science · doi:10.1002/psc.2836 · Cited by 760
Continuous Flow Techniques in Organic Synthesis
Jas, G., & Kirschning, A. (2003) · Chemistry – A European Journal · doi:10.1002/chem.200305212 · Cited by 466
Continuous‐Flow Solid‐Phase Peptide Synthesis: A Revolutionary Reduction of the Amino Acid Excess
Mándity, I. M., Olasz, B., Ötvös, S. B., & Fülöp, F. (2014) · ChemSusChem · doi:10.1002/cssc.201402436 · Cited by 65
Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis
(2020) · doi:10.1021/acscentsci.0c00979 · Cited by 61
The design and discovery of lixisenatide for the treatment of type 2 diabetes mellitus
Christensen, M., Miossec, P., Larsen, B. D., Werner, U., & Knop, F. K. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.942638 · Cited by 34
Metadata
- Authors
- Dryland, A., & Sheppard, R. C.
- Venue
- Journal of the Chemical Society, Perkin Transactions 1
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 1986
- Pages
- 125
- ISSN
- 1364-5463 (ISSN-L)
- 0300-922X
- OpenAlex
- W2064550368
- Cited by
- 192
- References
- 0
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Peptide synthesis. Part 8. A system for solid-phase synthesis under low pressure continuous flow conditions. https://app.cochat.ai/papers/10.1039/p19860000125
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- Dryland, A., & Sheppard, R. C. (1986). Peptide synthesis. Part 8. A system for solid-phase synthesis under low pressure continuous flow conditions. Journal of the Chemical Society, Perkin Transactions 1. https://doi.org/10.1039/p19860000125
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
